Summary

Full nameguanosine
Short nameG
MODOMICS codeG
Nature of the modified residueNatural
RNAMods codeG
Residue unique ID38
Found in RNAYes
Related nucleotides235
Found in phylogenyArchaea, Eubacteria, Eukaryota

Chemical information

Sum formulaC10H13N5O5
Type of moietynucleoside
Degeneracynot applicable
PubChem ID6802
SMILESNc1[nH]c(=O)c2nc[n]([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
logP-2.1055
TPSA159.51
Number of atoms20
Number of Hydrogen Bond Acceptors 1 (HBA1)8
Number of Hydrogen Bond Acceptors 2 (HBA2)9
Number of Hydrogen Bond Donors (HBD)5
PDB no exac match , link to the most similar ligand GMP
PDB exact match , link to the most similar ligand GMP
HMDB (Human Metabolome Database) exact match HMDB0000133
HMDB (Human Metabolome Database) no exac match, link to the most similar ligand HMDB0000133
InChIInChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
InChIKeyNYHBQMYGNKIUIF-UUOKFMHZSA-N
Search the molecule in external databases ChEMBL  ChemAgora  ChEBI  PubChem Compound Database  Ligand Expo  ChemSpider  WIPO 

* Chemical properties calculated with Open Babel - O'Boyle et al. Open Babel: An open chemical toolbox. J Cheminform 3, 33 (2011) (link)


Download Structures

2D   .png .mol .mol2 .sdf .pdb .smi
3D   .mol .mol2 .sdf .pdb

Tautomers

Tautomers SMILES
N=c1[nH]c(=O)c2ncn(C3OC(CO)C(O)C3O)c2[nH]1 tautomer #0
Nc1nc(O)c2ncn(C3OC(CO)C(O)C3O)c2n1 tautomer #1
Nc1nc(=O)c2ncn(C3OC(CO)C(O)C3O)c2[nH]1 tautomer #2
Nc1[nH]c(=O)c2ncn(C3OC(CO)C(O)C3O)c2n1 tautomer #3
N=c1[nH]c(O)c2ncn(C3OC(CO)C(O)C3O)c2n1 tautomer #4
N=C1NC(=O)C2N=CN(C3OC(CO)C(O)C3O)C2=N1 tautomer #5
Nc1nc(O)c2ncn(C3OC(CO)C(O)C3O)c2n1 tautomer #6
NC1=NC(=O)C2N=CN(C3OC(CO)C(O)C3O)C2=N1 tautomer #7
N=c1nc(O)c2ncn(C3OC(CO)C(O)C3O)c2[nH]1 tautomer #8
N=C1N=C(O)C2N=CN(C3OC(CO)C(O)C3O)C2=N1 tautomer #9

Tautomer image Show Image

Predicted CYP Metabolic Sites

CYP3A4 CYP2D6 CYP2C9
G G G

* CYP Metabolic sites predicted with SMARTCyp. SMARTCyp is a method for prediction of which sites in a molecule that are most liable to metabolism by Cytochrome P450. It has been shown to be applicable to metabolism by the isoforms 1A2, 2A6, 2B6, 2C8, 2C19, 2E1, and 3A4 (CYP3A4), and specific models for the isoform 2C9 (CYP2C9) and isoform 2D6 (CYP2D6). CYP3A4, CYP2D6, and CYP2C9 are the three of the most important enzymes in drug metabolism since they are involved in the metabolism of more than half of the drugs used today. The three top-ranked atoms are highlighted. See: SmartCYP and SmartCYP - background; Patrik Rydberg, David E. Gloriam, Lars Olsen, The SMARTCyp cytochrome P450 metabolism prediction server, Bioinformatics, Volume 26, Issue 23, 1 December 2010, Pages 2988–2989 (link)


LC-MS Information

Monoisotopic mass283.0917
Average mass283.241
[M+H]+284.0995
Product ions152
Normalized LC elution time *1
LC elution order/characteristics not available

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

Reactions producing guanosine

Name
xX:G

Reactions starting from guanosine

Name
G:Gm
G:m7G
G:m2G
G:m1G
G:Gr(p)

Last modification of this entry: Sept. 29, 2021


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