Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase
Synonym: YleA
GI: 83288203
Orf: b0661
COG: COG0621
UniProt: P0AEI1
Alpha Fold Predicted Structure: AF-P0AEI1-F1
Enzyme type: methylthiotransferase
Position of modification - modification: t:37 - ms2i6A



Protein sequence:

MTKKLHIKTWGCQMNEYDSSKMADLLDATHGYQLTDVAEEADVLLLNTCSIREKAQEKVFHQLGRWKLLKEKNPDLIIGVGGCVASQEGEHIRQRAHYVDIIFGPQTLHRLPEMINSVRGDRSPVVDISFPEIEKFDRLPEPRAEGPTAFVSIMEGCNKYCTYCVVPYTRGEEVSRPSDDILFEIAQLAAQGVREVNLLGQNVNAWRGENYDGTTGSFADLLRLVAAIDGIDRIRFTTSHPIEFTDDIIEVYRDTPELVSFLHLPVQSGSDRILNLMGRTHTALEYKAIIRKLRAARPDIQISSDFIVGFPGETTEDFEKTMKLIADVNFDMSYSFIFSARPGTPAADMVDDVPEEEKKQRLYILQERINQQAMAWSRRMLGTTQRILVEGTSRKSIMELSGRTENNRVVNFEGTPDMIGKFVDVEITDVYPNSLRGKVVRTEDEMGLRVAETPESVIARTRKENDLGVGYYQP

Comments:

Bacterial MiaB works on A36-i6A37-containing tRNA. It displays a N-terminal TRAM domain and a C-terminal catalytic radical SAM domain with two [4Fe-4S] clusters coordinated with 3 cysteines and an exchangeable S-AdoMet. It works with IcsS/IcsU as the donor of sulfur. Belongs to the same family of methylthiotransferases as B subtilis MTaB (YqeV), mammalian MtaB (Cdkal1) and protein methylthiotransferase RimO. A MiaB-CDKAL1-like enzyme is present in Archaea, while MiaA/Mod5 is totally absent. Its function is still elusive (2012). MnmE-GTpase negatively regulates the activity of MiaG in E. coli.





Alpha Fold Predicted Structure:




Parsing response... [435428/435428]


Clear Selection and Reset Camera

Protein sequence:

M T K K L H I K T W G C Q M N E Y D S S K M A D L L D A T H G Y Q L T D V A E E A D V L L L N T C S I R E K A Q E K V F H Q L G R W K L L K E K N P D L I I G V G G C V A S Q E G E H I R Q R A H Y V D I I F G P Q T L H R L P E M I N S V R G D R S P V V D I S F P E I E K F D R L P E P R A E G P T A F V S I M E G C N K Y C T Y C V V P Y T R G E E V S R P S D D I L F E I A Q L A A Q G V R E V N L L G Q N V N A W R G E N Y D G T T G S F A D L L R L V A A I D G I D R I R F T T S H P I E F T D D I I E V Y R D T P E L V S F L H L P V Q S G S D R I L N L M G R T H T A L E Y K A I I R K L R A A R P D I Q I S S D F I V G F P G E T T E D F E K T M K L I A D V N F D M S Y S F I F S A R P G T P A A D M V D D V P E E E K K Q R L Y I L Q E R I N Q Q A M A W S R R M L G T T Q R I L V E G T S R K S I M E L S G R T E N N R V V N F E G T P D M I G K F V D V E I T D V Y P N S L R G K V V R T E D E M G L R V A E T P E S V I A R T R K E N D L G V G Y Y Q P
50100150200250300350400450SequenceGHTBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-P0AEI1-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-P0AEI1-F1.cif  
DSSP Secondary Structures   P0AEI1.dssp  





Publications:

Links:

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