Gar1 from Saccharomyces cerevisiae - protein summary.
H/ACA ribonucleoprotein complex subunit 1
Essential subunit of the nucleolar Box H/ACA ribonucleoprotein particles (RNP) involved in 2’-O-methylation of several cellular RNA (mainly rRNA and snRNA), including intron-containing pre-RNA in yeast. Gar1 is distinguished from the assembly factor Naf1 by containing a C-terminal extension that controls substrate turnover and the Gar1-Naf1 exchange during H/ACA RNP maturation.
GAR1 is an essential small nucleolar RNP protein required for pre-rRNA processing in yeast.
Girard JP, Lehtonen H, Caizergues-Ferrer M, Amalric F, Tollervey D, Lapeyre B
Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase.
Li S, Duan J, Li D, Yang B, Dong M, Ye K
Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita.
Li S, Duan J, Li D, Ma S, Ye K
The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p.
Leulliot N, Godin KS, Hoareau-Aveilla C, Quevillon-Cheruel S, Varani G, Henry Y, Van Tilbeurgh H...
J Mol Biol
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