Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA epoxyqueuosine(34) reductase
Synonym: YjeS
GI: 16131988
COG: COG1600
UniProt: P39288
Structures: | |
Enzyme type: oxidoreductase
Position of modification - modification: t:34 - Q



Protein sequence:

MSEPLDLNQLAQKIKQWGLELGFQQVGITDTDLSESEPKLQAWLDKQYHGEMDWMARHGMLRARPHELLPGTLRVISVRMNYLPANAAFASTLKNPKLGYVSRYALGRDYHKLLRNRLKKLGEMIQQHCVSLNFRPFVDSAPILERPLAEKAGLGWTGKHSLILNREAGSFFFLGELLVDIPLPVDQPVEEGCGKCVACMTICPTGAIVEPYTVDARRCISYLTIELEGAIPEELRPLMGNRIYGCDDCQLICPWNRYSQLTTEEDFSPRKPLHAPELIELFAWSEEKFLKVTEGSAIRRIGHLRWLRNIAVALGNAPWDETILTALESRKGEHPLLDEHIAWAIAQQIERRNACIVEVQLPKKQRLVRVIEKGLPRDA

Comments:

Vitamine B12 dependent.




Reaction Substrate SubstrateType Position (Anti)Codon Modified (Anti)Codon Amino Acid Change Transcript Name Transcript Region Cellular Localization References
oQ:Q tRNA (t)   34



Publications:

Title Authors Journal Details PubMed Id DOI
New function of vitamin B12: cobamide-dependent reduction of epoxyqueuosine to queuosine in tRNAs of Escherichia coli and Salmonella typhimurium. Frey B, McCloskey J, Kersten W, Kersten H J Bacteriol [details] 3129401 -
Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes. Reuter K, Slany R, Ullrich F, Kersten H J Bacteriol [details] 1706703 -
Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification. Miles ZD, McCarty RM, Molnar G, Bandarian V Proc Natl Acad Sci U S A [details] 21502530 -

Links:

_EcoCyc_