Modomics - A Database of RNA Modifications

Full name:	tRNA epoxyqueuosine(34) reductase
Synonym:	YjeS
GI:	16131988
Orf:
COG:	COG1600
UniProt:	P39288
Structures:	\| \|
Complex:
Enzyme type:	oxidoreductase
Position of modification - modification:	t:34 - Q

Comments:

Vitamine B12 dependent.

Protein sequence:

MSEPLDLNQLAQKIKQWGLELGFQQVGITDTDLSESEPKLQAWLDKQYHGEMDWMARHGMLRARPHELLPGTLRVISVRMNYLPANAAFASTLKNPKLGY
VSRYALGRDYHKLLRNRLKKLGEMIQQHCVSLNFRPFVDSAPILERPLAEKAGLGWTGKHSLILNREAGSFFFLGELLVDIPLPVDQPVEEGCGKCVACM
TICPTGAIVEPYTVDARRCISYLTIELEGAIPEELRPLMGNRIYGCDDCQLICPWNRYSQLTTEEDFSPRKPLHAPELIELFAWSEEKFLKVTEGSAIRR
IGHLRWLRNIAVALGNAPWDETILTALESRKGEHPLLDEHIAWAIAQQIERRNACIVEVQLPKKQRLVRVIEKGLPRDA

Enzymatic activities:

Reaction	Substrate	Type	Position
oQ:Q	tRNA (t)		34

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
New function of vitamin B12: cobamide-dependent reduction of epoxyqueuosine to queuosine in tRNAs of Escherichia coli and Salmonella typhimurium.	Frey B, McCloskey J, Kersten W, Kersten H	J Bacteriol	[details]	3129401	-
Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes.	Reuter K, Slany R, Ullrich F, Kersten H	J Bacteriol	[details]	1706703	-
Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification.	Miles ZD, McCarty RM, Molnar G, Bandarian V	Proc Natl Acad Sci U S A	[details]	21502530	-

Links:

_EcoCyc_

_EcoCyc_