| Full name: |
tRNA-specific adenosine deaminase subunit TAD3 |
| Synonym: |
ADAT3 |
| GI: |
23822264 |
| Orf: |
YLR316C |
| COG: |
COG0590 |
| UniProt: |
Q9URQ3 |
| Structures: |
|
|
|
| Complex: |
Tad2/3 |
| Enzyme type: |
deaminase |
| Position of modification - modification: |
t:34 - I
|
Comments:
Tad2 is a part of the heterodimeric deaminase Tad2/3 (ADAT2/3) which is responsible for A:I reaction in tRNA position 34. Zinc enzyme.
Protein sequence:
MVKKVNNPLKIDYQNGIIENRLLQIRNFKDVNTPKLINVWSIRIDPRDSKKVIELIRNDFQKNDPVSLRHLKRIRKDIETSTLEVVLCSKEYICDEGEIN
NKLKSIWVGTKKYELSDDIEVPEFAPSTKELNNAWSVKYWPLIWNGNPNDQILNDYKIDMQEVRNELSRASTLSVKMATAGKQFPMVSVFVDPSRKKDKV
VAEDGRNCENSLPIDHSVMVGIRAVGERLREGVDEDANSYLCLDYDVYLTHEPCSMCSMALIHSRVRRVVFLTEMQRTGSLKLTSGDGYCMNDNKQLNST
YEAFQWIGEEYPVGQVDRDVCC
Enzymatic activities:
| Reaction
| Substrate
| Type
| Position
|
|
A:I
|
tRNA (t) |
Pro/IGG/eukaryotic cytosol |
34 |
|
A:I
|
tRNA (t) |
Val/IAC/prokaryotic cytosol |
34 |
|
A:I
|
tRNA (t) |
Thr/IGU/prokaryotic cytosol |
34 |
|
A:I
|
tRNA (t) |
Ser/IGA/prokaryotic cytosol |
34 |
|
A:I
|
tRNA (t) |
Ile/IAU/prokaryotic cytosol |
34 |
|
A:I
|
tRNA (t) |
Arg/ICG/prokaryotic cytosol |
34 |
|
A:I
|
tRNA (t) |
Ala/IGC/prokaryotic cytosol |
34 |
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| An adenosine deaminase that generates inosine at the wobble position of tRNAs. |
Gerber AP, Keller W |
Science |
[details]
|
10550050
|
-
|
| A-to-I and C-to-U editing within transfer RNAs. |
Su AA, Randau L |
Biochemistry (Mosc) |
[details]
|
22022967
|
-
|
| Determinants of tRNA editing and modification: Avoiding conundrums, affecting function. |
Paris Z, Fleming IM, Alfonzo JD |
Semin Cell Dev Biol |
[details]
|
22024020
|
-
|
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