| Full name: |
Ribosomal RNA large subunit methyltransferase M |
| Synonym: |
YgdE |
| GI: |
83287984 |
| Orf: |
b1976 |
| COG: |
COG2933 |
| UniProt: |
P0ADR6 |
| Structures: |
|
|
|
| Complex: |
|
| Enzyme type: |
methyltransferase |
| Position of modification - modification: |
l:2498(2498) - Cm
|
Comments:
RlmM catalyzes the 2′-O-methylation at nucleotide C2498 in a single stranded part of the peptidyl transferase loop (between hairpins 89 and 90, Domain V) of E. coli 23S rRNA. Methylation occurs in naked 23S rRNA, but not in assembled 50S subunits or ribosomes. RlmM is placed in the cluster of orthologous groups COG2933 together with S-adenosylmethionine-dependent, Rossmann-fold methyltransferases (notably fibrillarin Nop1).
Protein sequence:
MNKVVLLCRPGFEKECAAEITDKAGQREIFGFARVKENAGYVIYECYQPDDGDKLIRELPFSSLIFARQWFVVGELLQHLPPEDRITPIVGMLQGVVEKG
GELRVEVADTNESKELLKFCRKFTVPLRAALRDAGVLANYETPKRPVVHVFFIAPGCCYTGYSYSNNNSPFYMGIPRLKFPADAPSRSTLKLEEAFHVFI
PADEWDERLANGMWAVDLGACPGGWTYQLVKRNMWVYSVDNGPMAQSLMDTGQVTWLREDGFKFRPTRSNISWMVCDMVEKPAKVAALMAQWLVNGWCRE
TIFNLKLPMKKRYEEVSHNLAYIQAQLDEHGINAQIQARQLYHDREEVTVHVRRIWAAVGGRRDER
Enzymatic activities:
| Reaction
| Substrate
| Type
| Position
|
|
C:Cm
|
rRNA (r) |
LSU/23S/prokaryotic cytosol |
2498 |
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| YgdE is the 2'-O-ribose methyltransferase RlmM specific for nucleotide C2498 in bacterial 23S rRNA. |
Purta E, O'Connor M, Bujnicki JM, Douthwaite S |
Mol Microbiol |
[details]
|
19400805
|
-
|
| RNA nucleotide methylation. |
Motorin Y, Helm M. |
Wiley Interdiscip Rev RNA |
[details]
|
21823225
|
-
|
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