Full name: tRNA-specific adenosine deaminase
Synonym: YfhC
GI: 90108581
Orf: yfhC, b2559
COG: COG0590
UniProt: P68398
Structures: | 1Z3A |
Complex:
Enzyme type: deaminase
Position of modification - modification: t:34 - I

Comments:

Homodimeric enzymecontaining zinc. Catalyzes A:I editing in tRNAArg in position 34. The modification is essential for proper decoding. Structure in complex with RNA was solved for Staphylococcus aureus (2B3J).

Protein sequence:

MRRAFITGVFFLSEVEFSHEYWMRHALTLAKRAWDEREVPVGAVLVHNNRVIGEGWNRPIGRHDPTAHAE IMALRQGGLVMQNYRLIDATLYVTLEPCVMCAGAMIHSRIGRVVFGARDAKTGAAGSLMDVLHHPGMNHR VEITEGILADECAALLSDFFRMRRQEIKAQKKAQSSTD

Enzymatic activities:

Reaction Substrate Type Position
A:I tRNA (t) Arg/ICG/prokaryotic cytosol 34

Publications:

Title Authors Journal Details PubMed Id DOI
tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli. Wolf J, Gerber AP, Keller W EMBO J [details] 12110595 -
Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase. Kim J, Malashkevich V, Roday S, Lisbin M, Schramm VL, Almo SC Biochemistry [details] 16700551 -
A-to-I and C-to-U editing within transfer RNAs. Su AA, Randau L Biochemistry (Mosc) [details] 22022967 -
Determinants of tRNA editing and modification: Avoiding conundrums, affecting function. Paris Z, Fleming IM, Alfonzo JD Semin Cell Dev Biol [details] 22024020 -

Links:

_Wikipedia_-_RNA_editing_
_Wikipedia_-_Deamination_
_EcoCyc_
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