ID Card:
Full name:
23S rRNA (uracil-C(5))-methyltransferase RlmCD
Synonym:
YefA
GI:
50401309
Orf:
BSU06730
COG:
COG2265
UniProt:
O31503
Alpha Fold Predicted Structure:
AF-O31503-F1
Enzyme type:
methyltransferase
Position of modification - modification:
l :749(747) - m5U l :1968(1939) - m5U
Protein sequence:
MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEEKAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQKQVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDIIDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIVFITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLIGDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAKKVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRKGCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVECCVLIKLKE
Comments:
Methylation of U747 and U1939 in B. subtilis rRNA is catalysed by a single enzyme while in E. coli two separate enzymes (RlmC and RlmD) are responsible for these two modifications.
Alpha Fold Predicted Structure:
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Protein sequence:
M
K
M
K
P
P
V
E
K
N
E
Y
Y
D
V
T
F
E
D
L
T
H
E
G
A
G
V
A
K
V
Q
G
F
P
I
F
V
P
N
A
L
P
E
E
K
A
Q
I
K
V
T
R
V
K
K
G
F
A
F
G
R
L
I
E
L
K
E
E
S
P
H
R
T
D
A
P
C
P
I
Y
K
Q
C
G
G
C
Q
L
Q
H
M
T
Y
E
G
Q
L
L
F
K
Q
K
Q
V
K
D
V
L
E
R
I
G
K
L
D
L
S
K
V
T
V
H
P
T
L
G
M
E
D
P
W
N
Y
R
N
K
A
Q
V
P
V
G
E
R
E
G
G
L
V
A
G
F
Y
Q
Q
R
S
H
D
I
I
D
M
S
A
C
L
I
Q
Q
S
K
N
D
E
A
V
Q
A
V
K
D
I
C
A
N
Y
G
V
K
A
Y
N
E
E
R
H
K
G
W
L
R
H
I
M
V
R
Y
G
V
V
T
G
E
M
M
I
V
F
I
T
R
T
S
D
F
P
H
K
A
K
I
I
E
D
I
T
A
Q
F
P
H
V
K
S
I
V
Q
N
I
N
P
N
K
T
N
V
I
F
G
N
E
T
N
V
I
W
G
E
E
Y
I
Y
D
L
I
G
D
V
K
F
A
I
S
A
R
S
F
Y
Q
V
N
P
E
Q
T
K
V
L
Y
D
K
A
L
E
Y
A
E
L
Q
G
E
E
T
V
I
D
A
Y
C
G
I
G
T
I
S
L
F
L
A
K
Q
A
K
K
V
Y
G
V
E
I
V
P
E
A
I
E
D
A
K
R
N
A
E
L
N
G
N
T
N
A
E
F
A
V
G
E
A
E
T
V
I
P
K
W
Y
E
E
G
I
T
A
D
T
L
V
V
D
P
P
R
K
G
C
D
E
A
L
L
R
T
I
V
E
M
K
P
K
R
V
V
Y
V
S
C
N
P
G
T
L
A
R
D
L
R
V
L
E
D
G
G
Y
V
T
R
E
V
Q
P
V
D
M
F
P
H
T
N
H
V
E
C
C
V
L
I
K
L
K
E
50 100 150 200 250 300 350 400 450 Sequence H T B S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
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