Tsr from Streptomyces cyaneus - protein summary.
Thiostrepton Resistance 23S rRNA methyltransferase
Position of modification - modification:
l:1067(1067) - Am
Methylation site was determined for E. coli rRNA.
Nucleotide sequences encoding and promoting expression of three antibiotic resistance genes indigenous to Streptomyces.
Bibb MJ, Bibb MJ, Ward JM, Cohen SN
Mol Gen Genet
Structure of the thiostrepton resistance methyltransferase.S-adenosyl-L-methionine complex and its interaction with ribosomal RNA.
Dunstan MS, Hang PC, Zelinskaya NV, Honek JF, Conn GL
J Biol Chem
Overexpression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2'-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA.
Bechthold A, Floss HG
Eur J Biochem
Binding Induced RNA Conformational Changes Control Substrate Recognition and Catalysis by the Thiostrepton-resistance Methyltransferase (Tsr).
Kuiper EG, Conn GL...
J Biol Chem
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