Modomics - A Database of RNA Modifications

Full name:	rRNA (adenosine-2'-O-)-methyltransferase
Synonym:	Nosiheptide-resistance methyltransferase
GI:	1654413
Orf:	nsh
COG:
UniProt:	P72385
Structures:	\| 3NK6 \| 3NK7 \|
Complex:
Enzyme type:	methyltransferase
Position of modification - modification:	l:1067(1067) - Am

Comments:

Methylation site was determined for E. coli rRNA.

Protein sequence:

MTARQHTDVLPRPSPATALMASLLPARAVAAEAFGDGHDEDWFGQLLPAEARLMAGAGEKRRRDFAGVRVCARRALRTLGHAPVPLLPGPRGEPRWPDGV
VGSLTHCAGYRAAVVARPGPGLAGVGIDAEPHAPLDADVLEMVASPAERAHLALLARTRPGVHWGRLLFCVKEAVFKAWYPAARCELGFLEADVRFTADG
PHSADGPHSADGRYGTDGMHGIVTATLTRAGPFAAVSGRWRVAGGVIATAVVI

Enzymatic activities:

Reaction	Substrate	Type	Position
A:Am	rRNA (r)	LSU/23S/prokaryotic cytosol	1067

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Crystallization and preliminary crystallographic analysis of nosiheptide-resistance methyltransferase from Streptomyces actuosus in complex with SAM.	Yang H, Wang P, Dong Z, Li X, Gong R, Yang Y, Li Z, Xu Y, Xu Y	Acta Crystallogr Sect F Struct Biol Cryst Commun	[details]	20445264	-