| Full name: |
tRNA-specific adenosine deaminase 1 |
| Synonym: |
hADAT1 |
| GI: |
302058269 |
| Orf: |
ADAT1 |
| COG: |
|
| UniProt: |
Q9BUB4 |
| Structures: |
|
|
|
| Complex: |
|
| Enzyme type: |
deaminase |
| Position of modification - modification: |
t:37 - m1I
|
Comments:
Specifically deaminates adenosine 37 to inosine in exclusively cytoplasmic tRNA-Ala. The anticodon stem-loop of tRNAAla) alone is not a functional substrate for hADAT1.
Protein sequence:
MWTADEIAQLCYEHYGIRLPKKGKPEPNHEWTLLAAVVKIQSPADKACDTPDKPVQVTKEVVSMGTGTKC
IGQSKMRKNGDILNDSHAEVIARRSFQRYLLHQLQLAATLKEDSIFVPGTQKGVWKLRRDLIFVFFSSHT
PCGDASIIPMLEFEDQPCCPVFRNWAHNSSVEASSNLEAPGNERKCEDPDSPVTKKMRLEPGTAAREVTN
GAAHHQSFGKQKSGPISPGIHSCDLTVEGLATVTRIAPGSAKVIDVYRTGAKCVPGEAGDSGKPGAAFHQ
VGLLRVKPGRGDRTRSMSCSDKMARWNVLGCQGALLMHLLEEPIYLSAVVIGKCPYSQEAMQRALIGRCQ
NVSALPKGFGVQELKILQSDLLFEQSRSAVQAKRADSPGRLVPCGAAISWSAVPEQPLDVTANGFPQGTT
KKTIGSLQARSQISKVELFRSFQKLLSRIARDKWPHSLRVQKLDTYQEYKEAASSYQEAWSTLRKQVFGS
WIRNPPDYHQFK
Enzymatic activities:
| Reaction
| Substrate
| Type
| Position
|
|
A:I
|
tRNA (t) |
Ala/IGC/unknown |
37 |
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes. |
Maas S, Gerber AP, Rich A... |
Proc Natl Acad Sci U S A |
[details]
|
10430867
|
-
|
Links: