Full name: |
tRNA-specific adenosine deaminase 1 |
Synonym: |
hADAT1 |
GI: |
302058269 |
Orf: |
ADAT1 |
COG: |
|
UniProt: |
Q9BUB4 |
Structures: |
|
|
|
Complex: |
|
Enzyme type: |
deaminase |
Position of modification - modification: |
t:37 - m1I
|
Comments:
Specifically deaminates adenosine 37 to inosine in exclusively cytoplasmic tRNA-Ala. The anticodon stem-loop of tRNAAla) alone is not a functional substrate for hADAT1.
Protein sequence:
MWTADEIAQLCYEHYGIRLPKKGKPEPNHEWTLLAAVVKIQSPADKACDTPDKPVQVTKEVVSMGTGTKCIGQSKMRKNGDILNDSHAEVIARRSFQRYL
LHQLQLAATLKEDSIFVPGTQKGVWKLRRDLIFVFFSSHTPCGDASIIPMLEFEDQPCCPVFRNWAHNSSVEASSNLEAPGNERKCEDPDSPVTKKMRLE
PGTAAREVTNGAAHHQSFGKQKSGPISPGIHSCDLTVEGLATVTRIAPGSAKVIDVYRTGAKCVPGEAGDSGKPGAAFHQVGLLRVKPGRGDRTRSMSCS
DKMARWNVLGCQGALLMHLLEEPIYLSAVVIGKCPYSQEAMQRALIGRCQNVSALPKGFGVQELKILQSDLLFEQSRSAVQAKRADSPGRLVPCGAAISW
SAVPEQPLDVTANGFPQGTTKKTIGSLQARSQISKVELFRSFQKLLSRIARDKWPHSLRVQKLDTYQEYKEAASSYQEAWSTLRKQVFGSWIRNPPDYHQ
FK
Enzymatic activities:
Reaction
| Substrate
| Type
| Position
|
A:I
|
tRNA (t) |
Ala/IGC/unknown |
37 |
Publications:
Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes. |
Maas S, Gerber AP, Rich A... |
Proc Natl Acad Sci U S A |
[details]
|
10430867
|
-
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Links:
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