Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA (cytidine(56)-2'-O)-methyltransferase
GI: 14521775
Orf: PAB1040
COG: COG1303
UniProt: Q9UYD1
Alpha Fold Predicted Structure: AF-Q9UYD1-F1
Enzyme type: methyltransferase
Position of modification - modification: t:56 - Cm



Protein sequence:

MIVVLRLGHRPERDKRVTTHVALTARAFGADGIIIVSEEVDLKVKESVEDVVERWGGPFFVKFEKSWRKVMKEFDGVKVHLTMYGIHIDDIIDELREKLREGRDFMVIVGAEKVPREVYELADYNVAIGNQPHSEVAALAVFLDRLLEGKGLRKEFKGAKLKIIPQARGKMVVEVQKDAKQAEASGEGASRKNGQLPS

Comments:

Contains SPOUT S-adenosylmethionine (AdoMet)-dependent methyltransferase domain which is also found in bacterial and yeast G18 tRNA 2'-O-methylases (SpoU, Trm3). Cm56 tRNA methylation is present only in archaea. In some species it is provided by a C/D sRNP.





Alpha Fold Predicted Structure:






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Protein sequence:

M I V V L R L G H R P E R D K R V T T H V A L T A R A F G A D G I I I V S E E V D L K V K E S V E D V V E R W G G P F F V K F E K S W R K V M K E F D G V K V H L T M Y G I H I D D I I D E L R E K L R E G R D F M V I V G A E K V P R E V Y E L A D Y N V A I G N Q P H S E V A A L A V F L D R L L E G K G L R K E F K G A K L K I I P Q A R G K M V V E V Q K D A K Q A E A S G E G A S R K N G Q L P S
20406080100120140160180MIVVLRLGHRPERDKRVTTHVALTARAFGADGIIIVSEEVDLKVKESVEDVVERWGGPFFVKFEKSWRKVMKEFDGVKVHLTMYGIHIDDIIDELREKLREGRDFMVIVGAEKVPREVYELADYNVAIGNQPHSEVAALAVFLDRLLEGKGLRKEFKGAKLKIIPQARGKMVVEVQKDAKQAEASGEGASRKNGQLPSSequenceGHTSN

Enter the variants

Position

Original

Variant

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9UYD1-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9UYD1-F1.cif  
DSSP Secondary Structures   Q9UYD1.dssp  





Publications: