ID Card:
Full name:
tRNA (cytidine(56)-2'-O)-methyltransferase
GI:
14521775
Orf:
PAB1040
COG:
COG1303
UniProt:
Q9UYD1
Alpha Fold Predicted Structure:
AF-Q9UYD1-F1
Enzyme type:
methyltransferase
Position of modification - modification:
t :56 - Cm
Protein sequence:
MIVVLRLGHRPERDKRVTTHVALTARAFGADGIIIVSEEVDLKVKESVEDVVERWGGPFFVKFEKSWRKVMKEFDGVKVHLTMYGIHIDDIIDELREKLREGRDFMVIVGAEKVPREVYELADYNVAIGNQPHSEVAALAVFLDRLLEGKGLRKEFKGAKLKIIPQARGKMVVEVQKDAKQAEASGEGASRKNGQLPS
Comments:
Contains SPOUT S-adenosylmethionine (AdoMet)-dependent methyltransferase domain which is also found in bacterial and yeast G18 tRNA 2'-O-methylases (SpoU, Trm3). Cm56 tRNA methylation is present only in archaea. In some species it is provided by a C/D sRNP.
Reaction
Substrate
SubstrateType
Position
(Anti)Codon
Modified (Anti)Codon
Amino Acid Change
Transcript Name
Transcript Region
Cellular Localization
References
C:Cm
tRNA
56
TΨC-loop
prokaryotic cytosol
15987815
Alpha Fold Predicted Structure:
Clear Selection and Reset Camera
Clear Selection
Reset Camera
Protein sequence:
M
I
V
V
L
R
L
G
H
R
P
E
R
D
K
R
V
T
T
H
V
A
L
T
A
R
A
F
G
A
D
G
I
I
I
V
S
E
E
V
D
L
K
V
K
E
S
V
E
D
V
V
E
R
W
G
G
P
F
F
V
K
F
E
K
S
W
R
K
V
M
K
E
F
D
G
V
K
V
H
L
T
M
Y
G
I
H
I
D
D
I
I
D
E
L
R
E
K
L
R
E
G
R
D
F
M
V
I
V
G
A
E
K
V
P
R
E
V
Y
E
L
A
D
Y
N
V
A
I
G
N
Q
P
H
S
E
V
A
A
L
A
V
F
L
D
R
L
L
E
G
K
G
L
R
K
E
F
K
G
A
K
L
K
I
I
P
Q
A
R
G
K
M
V
V
E
V
Q
K
D
A
K
Q
A
E
A
S
G
E
G
A
S
R
K
N
G
Q
L
P
S
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
The Cm56 tRNA modification in archaea is catalyzed either by a specific 2'-O-methylase, or a C/D sRNP.
Renalier MH, Joseph N, Gaspin C, Thebault P, Mougin A
RNA
[details]
15987815
-