Full name: tRNA (cytidine(56)-2'-O)-methyltransferase
Synonym:
GI: 14521775
Orf: PAB1040
COG: COG1303
UniProt: Q9UYD1
Structures: | |
Complex:
Enzyme type: methyltransferase
Position of modification - modification: t:56 - Cm

Comments:

Contains SPOUT S-adenosylmethionine (AdoMet)-dependent methyltransferase domain which is also found in bacterial and yeast G18 tRNA 2'-O-methylases (SpoU, Trm3). Cm56 tRNA methylation is present only in archaea. In some species it is provided by a C/D sRNP.

Protein sequence:

MIVVLRLGHRPERDKRVTTHVALTARAFGADGIIIVSEEVDLKVKESVEDVVERWGGPFFVKFEKSWRKV MKEFDGVKVHLTMYGIHIDDIIDELREKLREGRDFMVIVGAEKVPREVYELADYNVAIGNQPHSEVAALA VFLDRLLEGKGLRKEFKGAKLKIIPQARGKMVVEVQKDAKQAEASGEGASRKNGQLPS

Enzymatic activities:

Reaction Substrate Type Position
C:Cm tRNA (t) 56

Publications:

Title Authors Journal Details PubMed Id DOI
The Cm56 tRNA modification in archaea is catalyzed either by a specific 2'-O-methylase, or a C/D sRNP. Renalier MH, Joseph N, Gaspin C, Thebault P, Mougin A RNA [details] 15987815 -
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