Modomics - A Database of RNA Modifications

Full name:	tRNA (cytidine(32)-2′-O)-methyltransferase
Synonym:	Saci_0621
GI:	70606436
Orf:
COG:	COG0565
UniProt:	Q4JB16
Structures:	\| 4CNF \| 4CNG \|
Complex:
Enzyme type:	methyltransferase
Position of modification - modification:	t:32 - Cm

Comments:

Homolog of E. coli TrmJ. While the four canonical nucleosides are substrates of the Escherichia coli enzyme, the archaeal TrmJ can only methylate the ribose of a cytidine.

Protein sequence:

MTIRLVIVEPEGAYNLGFIARLVKNFLIDEFYVVNPKCDINEAIKFSAKGSEVIEKMMKITNNFDDAIRDVDLKIATSSIADIKGDLLRKSIRPIDLERL
IKDKKVAFIFGRESVGLTREEIAKSDFLLFIPANPEYPVLNLSHAVGIVLYELWRNRDNKVPTVSSEPIKLIDDYSKKITDILVNKEATKSMYLVLKRVL
IKGIEDNEEAMTIVRILRKIYVRLAKKENESDKLL

Enzymatic activities:

Reaction	Substrate	Type	Position
C:Cm	tRNA (t)		32

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Characterization of two homologous 2'-O-methyltransferases showing different specificities for their tRNA substrates.	Somme J, Van Laer B, Roovers M, Steyaert J, Versees W, Droogmans L...	RNA	[details]	24951554	-

Links:

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