ID Card:
Full name:
N6-adenosine-methyltransferase MT-A70-like
GI:
1063721623
UniProt:
O82486
Alpha Fold Predicted Structure:
AF-O82486-F1
Enzyme type:
methyltransferase
Protein sequence:
METESDDATITVVKDMRVRLENRIRTQHDAHLDLLSSLQSIVPDIVPSLDLSLKLISSFTNRPFVATPPLPEPKVEKKHHPIVKLGTQLQQLHGHDSKSMLVDSNQRDAEADGSSGSPMALVRAMVAECLLQRVPFSPTDSSTVLRKLENDQNARPAEKAALRDLGGECGPILAVETALKSMAEENGSVELEEFEVSGKPRIMVLAIDRTRLLKELPESFQGNNESNRVVETPNSIENATVSGGGFGVSGSGNFPRPEMWGGDPNMGFRPMMNAPRGMQMMGMHHPMGIMGRPPPFPLPLPLPVPSNQKLRSEEEDLKDVEALLSKKSFKEKQQSRTGEELLDLIHRPTAKEAATAAKFKSKGGSQVKYYCRYLTKEDCRLQSGSHIACNKRHFRRLIASHTDVSLGDCSFLDTCRHMKTCKYVHYELDMADAMMAGPDKALKPLRADYCSEAELGEAQWINCDIRSFRMDILGTFGVVMADPPWDIHMELPYGTMADDEMRTLNVPSLQTDGLIFLWVTGRAMELGRECLELWGYKRVEEIIWVKTNQLQRIIRTGRTGHWLNHSKEHCLVGIKGNPEVNRNIDTDVIVAEVRETSRKPDEMYAMLERIMPRARKLELFARMHNAHAGWLSLGNQLNGVRLINEGLRARFKASYPEIDVQPPSPPRASAMETDNEPMAIDSITA
Comments:
The components required for m6A in Arabidopsis included MTA, MTB, FIP37, VIRILIZER and the E3 ubiquitin ligase HAKAI. Downregulation of these proteins led to reduced relative m6A levels and shared pleiotropic phenotypes, which included aberrant vascular formation in the root, indicating that correct m6A methylation plays a role in developmental decisions during pattern formation.
Alpha Fold Predicted Structure:
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Protein sequence:
M
E
T
E
S
D
D
A
T
I
T
V
V
K
D
M
R
V
R
L
E
N
R
I
R
T
Q
H
D
A
H
L
D
L
L
S
S
L
Q
S
I
V
P
D
I
V
P
S
L
D
L
S
L
K
L
I
S
S
F
T
N
R
P
F
V
A
T
P
P
L
P
E
P
K
V
E
K
K
H
H
P
I
V
K
L
G
T
Q
L
Q
Q
L
H
G
H
D
S
K
S
M
L
V
D
S
N
Q
R
D
A
E
A
D
G
S
S
G
S
P
M
A
L
V
R
A
M
V
A
E
C
L
L
Q
R
V
P
F
S
P
T
D
S
S
T
V
L
R
K
L
E
N
D
Q
N
A
R
P
A
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K
A
A
L
R
D
L
G
G
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C
G
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L
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A
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M
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N
G
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M
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A
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R
T
R
L
L
K
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L
P
E
S
F
Q
G
N
N
E
S
N
R
V
V
E
T
P
N
S
I
E
N
A
T
V
S
G
G
G
F
G
V
S
G
S
G
N
F
P
R
P
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M
W
G
G
D
P
N
M
G
F
R
P
M
M
N
A
P
R
G
M
Q
M
M
G
M
H
H
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M
G
I
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L
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N
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S
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E
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A
L
L
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K
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K
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K
Q
Q
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R
T
G
E
E
L
L
D
L
I
H
R
P
T
A
K
E
A
A
T
A
A
K
F
K
S
K
G
G
S
Q
V
K
Y
Y
C
R
Y
L
T
K
E
D
C
R
L
Q
S
G
S
H
I
A
C
N
K
R
H
F
R
R
L
I
A
S
H
T
D
V
S
L
G
D
C
S
F
L
D
T
C
R
H
M
K
T
C
K
Y
V
H
Y
E
L
D
M
A
D
A
M
M
A
G
P
D
K
A
L
K
P
L
R
A
D
Y
C
S
E
A
E
L
G
E
A
Q
W
I
N
C
D
I
R
S
F
R
M
D
I
L
G
T
F
G
V
V
M
A
D
P
P
W
D
I
H
M
E
L
P
Y
G
T
M
A
D
D
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M
R
T
L
N
V
P
S
L
Q
T
D
G
L
I
F
L
W
V
T
G
R
A
M
E
L
G
R
E
C
L
E
L
W
G
Y
K
R
V
E
E
I
I
W
V
K
T
N
Q
L
Q
R
I
I
R
T
G
R
T
G
H
W
L
N
H
S
K
E
H
C
L
V
G
I
K
G
N
P
E
V
N
R
N
I
D
T
D
V
I
V
A
E
V
R
E
T
S
R
K
P
D
E
M
Y
A
M
L
E
R
I
M
P
R
A
R
K
L
E
L
F
A
R
M
H
N
A
H
A
G
W
L
S
L
G
N
Q
L
N
G
V
R
L
I
N
E
G
L
R
A
R
F
K
A
S
Y
P
E
I
D
V
Q
P
P
S
P
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R
A
S
A
M
E
T
D
N
E
P
M
A
I
D
S
I
T
A
100 200 300 400 500 600 Sequence G H T B S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
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