Full name: Multisite-specific tRNA:(cytosine-C(5))-methyltransferase trm4b
Synonym: tRNA (cytosine-5-)-methyltransferase trm4b
GI: None
Orf:
COG:
UniProt: O13935
Structures: | |
Complex: none
Enzyme type: methyltransferase
Position of modification - modification:

Comments:

Associates with MTA, FIP37, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences

Protein sequence:

MGKRNKKVTQGKRAYNDKSEIVLENKQFEGYYKKQNLFRGKPNDEFDSFMEYMRKPLPTTFRICGYRHHAFELKNHFEKYYVPSLKNVVHEGQTIPPPTV
LPWYPDGLAYIVDAQKDVIRKSPPLKRLQRFLVSENEAGNINRQEAVSMLPPLFLDVEPHHVILDMCAAPGSKTAQLIEAVYKKANIKDAAHDSKNLKSV
EGLVIANDADPKRAQMLVHQINRLNSPNILVVNHDASTMPNIYVKGSSPSDGLNVIEEKKILKFDRILADVPCSGDGTFRKNLSLWREWSANSAFSLHPL
QLRILIRGLQLLKVGGCLVYSTCSINPIENEAVVTAALKATGGAVSLVDVSKKLPLLKRDPGLLSWKVLDDSLNEFQSPAENTNDKIELTESMWPLPEEE
MSKLHIERCARLYPHMQNTGGFFVAVLQKTDPINSRSFDPKKYTASMEILPPENKRQRTEKGVDEASNSTLTKSGNSYFDEEPFVYINPDDTSIKTIVDF
YGIDPSFPRDQFFVRNQSGIPVRSIYFACSLFKEIIEANTNRVKFVHGGVRFFVKQEISQLLKDFSLKANKDICNFRIHSNGVNIISPFLNEKHFYDAGL
KDLKILVKNEYPHVEQFSESGMLKKEFEKMPLGCNILRVDAQTKDGALMDMLILQPIWRSPTSCNLMLARKEKQNLSLELFGMDV

Publications:

Title Authors Journal Details PubMed Id DOI
Division of labour: tRNA methylation by the NSun2 tRNA methyltransferases Trm4a and Trm4b in fission yeast. Martin Müller,Anke Samel-Pommerencke,Carine Legrand,Francesca Tuorto,Frank Lyko,Ann E Ehrenhofer-Murray RNA Biol [details] 30646830 -
Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. Maria Becker,Sara Müller,Wolfgang Nellen,Tomasz P Jurkowski,Albert Jeltsch,Ann E Ehrenhofer-Murray Nucleic Acids Res [details] 23074192 -

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