Modomics - A Database of RNA Modifications

ID Card:

Full name: 26S rRNA (cytosine-C(5))-methyltransferase nsun-5
UniProt: Q9NAA7
Alpha Fold Predicted Structure: AF-Q9NAA7-F1
Enzyme type: methyltransferase



Protein sequence:

MATDALYNEVAEIIRCVLAKEKSVRNAVYGSSYKNKKALLRLSCESLKFRPVFDEILQDKELKSMKRDANIGGSVELLYVLMYETLVGSGLTRCSQELKSVISRRIQRIKEVEHAMQDEGRGIKAMKEADDGMKKIQIPRYARINTLKWTADEAMKTLETEKWKILGTLKPENFAEMVTKMKDDEVYVDPHVENLIIFAPNIQNFYEYWMVEQRYLILQDKASCLPAFLLNPRPGSQVFDTCAAPGMKTSHAAAIMENQGKVWAMDRAADRVATMKQLLDASKVAIASSFCGDFLKTDVTDKKFSKVKFAIVDPPCSGSGIVKRMDEITGGNAEKERLEKLKNLQAMILKHALKLPGLKRAVYSTCSVHEEENEQVVDEVLLDTYVRQNYVLKKNVLPEWTYRGLKTYEVGEHCLRANPKVTLTNGFFVAVFERVKSSE

Comments:

S-adenosyl-L-methionine-dependent methyltransferase which methylates the carbon-5 position of cytosine 2381 to 5-methylcytosine (m5C2381) in 26S rRNA (Schosserer et al. 2015, Heissenberger et al. 2020 , Navarro et al. 2021 ). Plays a role in the production of mature 5S, 5.8S, 18S and 26S rRNAs and promotes the processing of the internally transcribed spacer 2 (ITS2), which separates the 5.8S and 26S rRNAs on large pre-rRNA precursors (Heissenberger et al. 2020 ,).





Alpha Fold Predicted Structure:




Downloading... [175866/409693]


Clear Selection and Reset Camera

Protein sequence:

M A T D A L Y N E V A E I I R C V L A K E K S V R N A V Y G S S Y K N K K A L L R L S C E S L K F R P V F D E I L Q D K E L K S M K R D A N I G G S V E L L Y V L M Y E T L V G S G L T R C S Q E L K S V I S R R I Q R I K E V E H A M Q D E G R G I K A M K E A D D G M K K I Q I P R Y A R I N T L K W T A D E A M K T L E T E K W K I L G T L K P E N F A E M V T K M K D D E V Y V D P H V E N L I I F A P N I Q N F Y E Y W M V E Q R Y L I L Q D K A S C L P A F L L N P R P G S Q V F D T C A A P G M K T S H A A A I M E N Q G K V W A M D R A A D R V A T M K Q L L D A S K V A I A S S F C G D F L K T D V T D K K F S K V K F A I V D P P C S G S G I V K R M D E I T G G N A E K E R L E K L K N L Q A M I L K H A L K L P G L K R A V Y S T C S V H E E E N E Q V V D E V L L D T Y V R Q N Y V L K K N V L P E W T Y R G L K T Y E V G E H C L R A N P K V T L T N G F F V A V F E R V K S S E
50100150200250300350400SequenceGHTBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9NAA7-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9NAA7-F1.cif  
DSSP Secondary Structures   Q9NAA7.dssp  





Publications:

Links:

_<font style="color:brown"_