ID Card:
| Full name: |
26S rRNA (cytosine-C(5))-methyltransferase nsun-1 |
| UniProt: |
Q9TYV5 |
| Enzyme type: |
|
| Position of modification - modification: |
:2982(None) - m5C
|
| Level of experimental evidence: |
3 |
| Level of experimental reliability: |
2 |
Protein sequence:
MAIVKKKKVSAASKAATEKPEVKKAVKRPVAETEAVTPKKKKLVKKVKKSAKKAHEEEPIEQVEKLQLIDDDEDGLEGLSFPGSDDEDLRDDYSDDDSDAGDHLPIEKKSAALDKQKEKIIAEGEEELQLNIANQATFELPTVEEIENEMKSVPNLEIVKQRIADVIQVLGDFKNRRDPQKSRENYVEVLKKDLCSQYGYNDYLMGKFMDLFPNGAELLEFLEANDNPRPVTIRANSLKVKRRDLAKNLINRGMNVDPAADWTKVGLVVYDSQVPVGATPEYLAGHYMIQGLNSLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLFANDANFTRCRAIIGNLHRLGVNNTVVCNLGGEEFSKIRPNGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLILSALDSLDANSPNGGYLVYSTCSVLVEENEAVVNFLLERRHCELVPTGLSIGVDGYTRFRDYRFHPSLSMTKRYYPHVHNIDGFYVAKIKKLSNAKMSKQGVMEKEKEKAAQKSQNKKNKAEAEASESSDDEEEKKNGVEVNGQKKPAKKQQQKKQKADGDDSDDDNNAPMKNIGSGARANKKRRNQKKAAEKQAAVKEDDGFNTVGNVKRAKKPTQFKSKVPKRAAARTGAKSVKNRRKKMLAKQQ
Comments:
NSUN-1 is responsible for writing the second C. elegans 26S m5C (position C2982). NSUN1 is a bona fide m5C rRNA writer enzyme that, if missing, directly entails physiological and developmental consequences.
| Reaction |
Substrate |
SubstrateType |
Position |
(Anti)Codon |
Modified (Anti)Codon |
Amino Acid Change |
Transcript Name |
Transcript Region |
Cellular Localization |
References |
|
C:m5C
|
rRNA (r) |
rRNA/rRNA/eukaryotic cytosol |
2982 |
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Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans |
33289480 |
|
[details]
|
33289480
|
10.7554/eLife.56205
|