| Full name: | 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA |
|---|---|
| UniProt: | P9WJ63 |
| Enzyme type: | |
| Position of modification - modification: |
:1409(None) - Cm :1920(None) - Cm |
| Level of experimental evidence: | 2 |
| Level of experimental reliability: | 2 |
MARRARVDAELVRRGLARSRQQAAELIGAGKVRIDGLPAVKPATAVSDTTALTVVTDSERAWVSRGAHKLVGALEAFAIAVAGRRCLDAGASTGGFTEVLLDRGAAHVVAADVGYGQLAWSLRNDPRVVVLERTNARGLTPEAIGGRVDLVVADLSFISLATVLPALVGCASRDADIVPLVKPQFEVGKGQVGPGGVVHDPQLRARSVLAVARRAQELGWHSVGVKASPLPGPSGNVEYFLWLRTQTDRALSAKGLEDAVHRAISEGP
Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA
| Reaction | Substrate | SubstrateType | Position | (Anti)Codon | Modified (Anti)Codon | Amino Acid Change | Transcript Name | Transcript Region | Cellular Localization | References |
|---|---|---|---|---|---|---|---|---|---|---|
| C:Cm | rRNA (r) | rRNA/rRNA/prokaryotic cytosol | 1409 | |||||||
| C:Cm | rRNA (r) | rRNA/rRNA/prokaryotic cytosol | 1920 |
| Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|
| Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs. | Johansen SK; Maus CE; Plikaytis BB; Douthwaite S | Mol Cell | [details] | 16857584 | - |
| Molecular characterization of tlyA gene product, Rv1694 of Mycobacterium tuberculosis: a non-conventional hemolysin and a ribosomal RNA methyl transferase. | Rahman A; Srivastava SS; Sneh A; Ahmed N; Krishnasastry MV | BMC Biochem | [details] | 20854656 | 10.1186/1471-2091-11-35 |
| 50S subunit recognition and modification by the <i>Mycobacterium tuberculosis</i> ribosomal RNA methyltransferase TlyA. | Laughlin ZT; Nandi S; Dey D; Zelinskaya N; Witek MA; Srinivas P; Nguyen HA; Kuiper EG; Comstock LR; Dunham CM; Conn GL | Proc Natl Acad Sci U S A | [details] | 35357969 | 10.1073/pnas.2120352119 |