ID Card:
| Full name: |
tRNA-specific adenosine deaminase subunit TAD2 |
| UniProt: |
V5DKK8 |
| Complex: |
Tad2/3 |
| Enzyme type: |
|
| Position of modification - modification: |
t:None - I
|
| Level of experimental evidence: |
5 |
| Level of experimental reliability: |
5 |
Protein sequence:
MGEGINDDKVVYCDAFMLAAFAEARAALAEGEVPVGCVLVPAEASCPANAGRLDDNNPNNSGASLGNLIAARGRNATNKEHHALAHAEFVAVEALLRDAAEKGRKPPASLAGYVLYVVVEPCIMCAAMLLYNRIKKVYFGCGNPRFGGNGTVLAVHAAKSTSAPAYESCGGHRAEEAITLLQEFYSRENSAAPDHKRRRKDI
Comments:
T. cruzi ADAT2 and ADAT3 proteins form a catalytically active heterodimer similar to eukaryotic ADATs. This enzyme complex catalyzes the essential adenosine-to-inosine (A34-to-I) editing in the wobble position (position 34) of certain tRNAs,
| Reaction |
Substrate |
SubstrateType |
Position |
(Anti)Codon |
Modified (Anti)Codon |
Amino Acid Change |
Transcript Name |
Transcript Region |
Cellular Localization |
References |
|
A:I
|
tRNA (t) |
tRNA/tRNA/eukaryotic cytosol |
34 |
|
|
|
|
|
|
|
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Characterization of ADAT2/3 molecules in Trypanosoma cruzi and regulation of mucin gene expression by tRNA editing. |
Bertotti S; Fleming I; Cámara MLM; Centeno Cameán C; Carmona SJ; Agüero F; Balouz V; Zahn A; Di Noia JM; Alfonzo JD; Buscaglia CA |
Biochem J |
[details]
|
35136964
|
10.1042/BCJ20210850
|