ID Card:
Full name:
tRNA-specific adenosine deaminase subunit TAD2
UniProt:
Q6P6J0
Structures:
|
7nz7 |
7nz8 |
7nz9 |
Complex:
Tad2/3
Enzyme type:
Position of modification - modification:
t :None - I
Level of experimental evidence:
2
Level of experimental reliability:
2
PDB Structures:
7nz7
7nz8
7nz9
}
7nz7
Structure Description:
Abstract of the PDB Structure's related Publication:
Download RCSB-PDB Structures:
Protein sequence:
MEEKVESTTTPDGPCVVSVQETEKWMEEAMRMAKEALENIEVPVGCLMVYNNEVVGKGRNEVNQTKNATRHAEMVAIDQVLDWCHQHGQSPSTVFEHTVLYVTVEPCIMCAAALRLMKIPLVVYGCQNERFGGCGSVLNIASADLPNTGRPFQCIPGYRAEEAVELLKTFYKQENPNAPKSKVRKKDCQKS
Comments:
Catalyses the eukaryotic wobble adenosine-to-inosine modification as the active component of the ADAT (ADAT2/ADAT3) complex that modifies up to eight tRNAs, requiring a full tRNA for activity.
Reaction
Substrate
SubstrateType
Position
(Anti)Codon
Modified (Anti)Codon
Amino Acid Change
Transcript Name
Transcript Region
Cellular Localization
References
A:I
tRNA (t)
tRNA/tRNA/eukaryotic cytosol
34
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination.
Ramos-Morales E; Bayam E; Del-Pozo-RodrĂguez J; Salinas-GiegĂ© T; Marek M; Tilly P; Wolff P; Troesch E; Ennifar E; Drouard L; Godin JD; Romier C
Nucleic Acids Res
[details]
34057470
10.1093/nar/gkab436