ID Card:
Full name:
Ribosomal RNA large subunit methyltransferase C
Synonym:
YbgF, RumB
GI:
2501407
Orf:
ybgF, b0859
COG:
COG2265
UniProt:
P75817
Alpha Fold Predicted Structure:
AF-P75817-F1
Enzyme type:
methyltransferase
Position of modification - modification:
l :747(747) - m5U
Protein sequence:
MQCALYDAGRCRSCQWIMQPIPEQLSAKTADLKNLLADFPVEEWCAPVSGPEQGFRNKAKMVVSGSVEKPLLGMLHRDGTPEDLCDCPLYPASFAPVFAALKPFIARAGLTPYNVARKRGELKYILLTESQSDGGMMLRFVLRSDTKLAQLRKALPWLHEQLPQLKVITVNIQPVHMAIMEGETEIYLTEQQALAERFNDVPLWIRPQSFFQTNPAVASQLYATARDWVRQLPVKHMWDLFCGVGGFGLHCATPDMQLTGIEIASEAIACAKQSAAELGLTRLQFQALDSTQFATAQGDVPELVLVNPPRRGIGKPLCDYLSTMAPRFIIYSSCNAQTMAKDIRELPGFRIERVQLFDMFPHTAHYEVLTLLVKQ
Comments:
RlmC (formerly RumB) methylates the conserved U747 in the loop of helix 35 of domain II of the large subunit rRNA. Recombinant E.coli RlmC is inactive in vitro. However, its archaeal recombinant RlmC paralog (P. abyssi PAB0760) is active on transcript corresponding to a fragment of rRNA encompassing the hairpin 33-35. AdoMet is the methyl group donor.
Alpha Fold Predicted Structure:
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Protein sequence:
M
Q
C
A
L
Y
D
A
G
R
C
R
S
C
Q
W
I
M
Q
P
I
P
E
Q
L
S
A
K
T
A
D
L
K
N
L
L
A
D
F
P
V
E
E
W
C
A
P
V
S
G
P
E
Q
G
F
R
N
K
A
K
M
V
V
S
G
S
V
E
K
P
L
L
G
M
L
H
R
D
G
T
P
E
D
L
C
D
C
P
L
Y
P
A
S
F
A
P
V
F
A
A
L
K
P
F
I
A
R
A
G
L
T
P
Y
N
V
A
R
K
R
G
E
L
K
Y
I
L
L
T
E
S
Q
S
D
G
G
M
M
L
R
F
V
L
R
S
D
T
K
L
A
Q
L
R
K
A
L
P
W
L
H
E
Q
L
P
Q
L
K
V
I
T
V
N
I
Q
P
V
H
M
A
I
M
E
G
E
T
E
I
Y
L
T
E
Q
Q
A
L
A
E
R
F
N
D
V
P
L
W
I
R
P
Q
S
F
F
Q
T
N
P
A
V
A
S
Q
L
Y
A
T
A
R
D
W
V
R
Q
L
P
V
K
H
M
W
D
L
F
C
G
V
G
G
F
G
L
H
C
A
T
P
D
M
Q
L
T
G
I
E
I
A
S
E
A
I
A
C
A
K
Q
S
A
A
E
L
G
L
T
R
L
Q
F
Q
A
L
D
S
T
Q
F
A
T
A
Q
G
D
V
P
E
L
V
L
V
N
P
P
R
R
G
I
G
K
P
L
C
D
Y
L
S
T
M
A
P
R
F
I
I
Y
S
S
C
N
A
Q
T
M
A
K
D
I
R
E
L
P
G
F
R
I
E
R
V
Q
L
F
D
M
F
P
H
T
A
H
Y
E
V
L
T
L
L
V
K
Q
50 100 150 200 250 300 350 Sequence H T B S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications: