Modomics - A Database of RNA Modifications

Reaction details:

Reaction type level 1: methylation
Reaction type level 2: alkylation
Reaction type level 3: group addition
Input group: H
Output group: *C
Introduced group name: methyl
Introduced group type: hydrocarbon
Site: extra group
Atom address: C5.N2
Modification level: 3

Enzymes that catalyse this reaction:

Acronym Full name Organism
MnmCD tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase / FAD-dependent cmnm(5)s(2)U34 oxidoreductase Escherichia coli
MnmD MnmD tRNA methyltransferase Aquifex aeolicus
 

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Image with reaction

Publications

Title Authors Journal Details PubMed Id DOI
Identification of a bifunctional enzyme MnmC involved in the biosynthesis of a hypermodified uridine in the wobble position of tRNA. Bujnicki JM, Oudjama Y, Roovers M, Owczarek S, Caillet J, Droogmans L RNA [details] 15247431 -