Summary:

NameGlioblastoma (A:m1A)
DescriptionTRM6/61 regulates the translation of a subset of mRNAs encoding proteins that play role in cancer.
Related RNA reactionA:m1A
Found in RNAtRNA
Modified Transcriptinitiator methionyl-tRNA (tRNAiMet)
Mapping Technology
Quantification techniquesqRT-PCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
Trmt6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 oncogene Homo sapiens
Trmt61A tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1032 TRM6/61 connects PKCα with translational control through tRNAi(Met) stabilization: impact on tumorigenesis. F Macari Oncogene [details] 26234676 10.1038/onc.2015.244

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