Summary

Full name4-demethylwyosine
IUPAC name3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-methyl-5H-imidazo[1,2-a]purin-9-one
Short nameimG-14
MODOMICS code4G
Synonyms
1, N2-Isopropenoguanosine
1,N-(2-Methyl-1,2-ethenediyl)guanosine
3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-methyl-5H-imidazo[1,2-a]purin-9-one
3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6-methyl-5H-imidazo[1,2-a]purin-9-one
4-demethylwyosine
4-Desmethylwyosine
6-methyl-3-(beta-D-ribofuranosyl)-3,5-dihydro-9H-imidazo[1,2-a]purin-9-one
AC1L9XOM
AIDS089810
CHEBI:64313
CID477875
imG-14
InChI=1/C13H15N5O5/c1-5-2-17-11(22)7-10(16-13(17)15-5)18(4-14-7)12-9(21)8(20)6(3-19)23-12/h2,4,6,8-9,12,19-21H,3H2,1H3,(H,15,16)/t6-,8-,9-,12-/m1/s1
QUZQVVNSDQCAOL-WOUKDFQISA-

Nature of the modified residueNatural
RNAMods code
Residue unique ID108
Found in RNAYes
Related nucleotides383
Enzymes TYW1 (Saccharomyces cerevisiae)
Taw1 (Methanocaldococcus jannaschii)
Taw1 (Pyrococcus abyssi)
Found in phylogenyArchaea, Eukaryota

Chemical information

Sum formulaC13H15N5O5
Type of moietynucleoside
Degeneracynot applicable
PubChem ID477875
SMILESCc1c[n]2c(c3nc[n]([C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O)c3[nH]c2n1)=O
logP-1.7078
TPSA137.9
Number of atoms23
Number of Hydrogen Bond Acceptors 1 (HBA1)7
Number of Hydrogen Bond Acceptors 2 (HBA2)9
Number of Hydrogen Bond Donors (HBD)4
PDB no exac match , link to the most similar ligand NOS
HMDB (Human Metabolome Database) no exac match, link to the most similar ligand HMDB0000195
InChIInChI=1S/C13H15N5O5/c1-5-2-17-11(22)7-10(16-13(17)15-5)18(4-14-7)12-9(21)8(20)6(3-19)23-12/h2,4,6,8-9,12,19-21H,3H2,1H3,(H,15,16)/t6-,8-,9-,12-/m1/s1
InChIKeyQUZQVVNSDQCAOL-WOUKDFQISA-N
Search the molecule in external databases ChEMBL  ChemAgora  ChEBI  PubChem Compound Database  Ligand Expo  ChemSpider  WIPO 
PubChem CID
PubChem SIDs

* Chemical properties calculated with Open Babel - O'Boyle et al. Open Babel: An open chemical toolbox. J Cheminform 3, 33 (2011) (link)


Download Structures

2D   .png .mol .mol2 .sdf .pdb .smi
3D   .mol .mol2 .sdf .pdb

Tautomers

Tautomers SMILES
Cc1cn2c(c3ncn(C4OC(CO)C(O)C4O)c3[nH]c2n1)=O tautomer #0
Cc1cn2c(c3ncn(C4OC(CO)C(O)C4O)c3nc2n1)O tautomer #1
CC=1Cn2c(c3ncn(C4OC(CO)C(O)C4O)c3nc2N1)=O tautomer #2
Cc1cn2c(c3ncn(C4OC(CO)C(O)C4O)c3nc2[nH]1)=O tautomer #3
C=C1Cn2c(c3ncn(C4OC(CO)C(O)C4O)c3nc2N1)=O tautomer #4
Cc1cn2C(C3N=CN(C4OC(CO)C(O)C4O)C3=Nc2n1)=O tautomer #5

Tautomer image Show Image

Predicted CYP Metabolic Sites

CYP3A4 CYP2D6 CYP2C9
imG-14 imG-14 imG-14

* CYP Metabolic sites predicted with SMARTCyp. SMARTCyp is a method for prediction of which sites in a molecule that are most liable to metabolism by Cytochrome P450. It has been shown to be applicable to metabolism by the isoforms 1A2, 2A6, 2B6, 2C8, 2C19, 2E1, and 3A4 (CYP3A4), and specific models for the isoform 2C9 (CYP2C9) and isoform 2D6 (CYP2D6). CYP3A4, CYP2D6, and CYP2C9 are the three of the most important enzymes in drug metabolism since they are involved in the metabolism of more than half of the drugs used today. The three top-ranked atoms are highlighted. See: SmartCYP and SmartCYP - background; Patrik Rydberg, David E. Gloriam, Lars Olsen, The SMARTCyp cytochrome P450 metabolism prediction server, Bioinformatics, Volume 26, Issue 23, 1 December 2010, Pages 2988–2989 (link)


LC-MS Information

Monoisotopic mass321.1073
Average mass321.289
[M+H]+322.1151
Product ions190
Normalized LC elution time * not available
LC elution order/characteristics not available

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

Chemical groups contained

TypeSubtype
ring modificationwyosine

Reactions producing 4-demethylwyosine

Name
m1G:imG-14

Reactions starting from 4-demethylwyosine

Name
imG-14:yW-86
imG-14:imG2
imG-14:imG

Last modification of this entry: Sept. 29, 2021


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