⬤ Hydrogen (H): white
⬤ Carbon (C): gray
⬤ Oxygen (O): red
⬤ Phosphorus (P): orange
⬤ Nitrogen (N): blue
⬤ Selenium (Se): gold
⬤ Sulfur (S): yellow
Summary
| Full name | N6-isopentenyladenosine |
| IUPAC name | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(3-methylbut-2-enylamino)purin-9-yl]oxolane-3,4-diol |
| Short name | i6A |
| MODOMICS code new | 2000000061A |
| MODOMICS code | 61A |
| Synonyms |
2058AC
2365-40-4 2iP Riboside 2-IPA 2iPA (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(3-methylbut-2-enylamino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(3-methylbut-2-enylamino)purin-9-yl]oxolane-3,4-diol 33156-15-9 6-(3,3- paragraph signthorn(1/4)x>>uI(c)+/-u>>u degrees +/->>u)aNssE masculineEUO 6-(3,3-Dimethylallylamino)-9-(b-D-ribofuranosyl)purine 6-(3,3-Dimethylallylamino)-9-(beta-D-ribofuranosyl)purine 6-(3,3-Dimethylallylamino)-9-(beta-D-ribofuranosyl)purine, 98% - 25MG 25mg 6-(3-Methyl-2-butenylamino)purine riboside 6-(.gamma.,.gamma.-Dimethylallylamino)purine riboside 6-(gamma,gamma-Dimethylallylamino)purine riboside 6-N-((3-Methyl-2-butenyl)amino)-9-beta-D-ribofuranosyl-9H-purine 6-N-((3-Methyl-2-butenyl)amino)-9-.beta.-D-ribofuranosyl-9H-purine 6-N-((3-Methyl-2-butenyl)amino)-9.beta.-D-ribofuranosylpurine 6-N-((3-Methyl-2-butenyl)amino)-9beta-D-ribofuranosylpurine 724G767 7724-76-7 8EU82FAZ5J 9.beta.-D-Ribofuranosyl-9H-purine, N-(3-methyl-2-butenylamino)- 9beta-D-Ribofuranosyl-9H-purine, N-(3-methyl-2-butenylamino)- AC1L2NEW ADENOSINE, N-(3-METHYL-2-BUTENYL)- AJ-09596 AKOS016009606 Au(2) IUUO C15-H21-N5-O4 C15H21N5O4 C16427 CAS-7724-76-7 CHEBI:62881 CHEMBL452867 CID24405 CS-W011925 D05726 DB11933 Dimethylallyladenosine DS-5147 DSSTox_CID_31617 DSSTox_GSID_57828 DSSTox_RID_97501 DTXSID1057828 EBD80372 EINECS 231-771-3 i6a ipa Isopentenyl adenine riboside Isopentenyl adenosine Isopentenyladenosine Isopentenyladenosine riboside LS-15154 MFCD00005741 N-(3-Methyl-2-butenyl)adenosine N-(3-methylbut-2-en-1-yl)adenosine N-(3-methylbut-2-enyl)adenosine N(6)-(2-isopentenyl)adenosine N6-(2-Isopentenyl)adenosine N6-(2-OiIiI(c)>>u)IUUO N(6)-(3-methyl-2-butenyl)adenosine N6-(3-Methyl-2-butenyl)adenosine N6-(|A,|A- paragraph signthorn(1/4)x>>uI(c)+/-u>>u)IUUO N6-(.DELTA.2-Isopentenyl)adenine riboside N-6-(delta-2-Isopentenyl)adenosine N6-(delta2-Isopentenyl)adenosine N6-(.DELTA.2-Isopentenyl)adenosine N(6)-(Delta(2)-isopentenyl)adenosine N6-Dimethylallyladenosine N6-(.gamma.,.gamma.-Dimethylallyl)adenosine N6-Isopentenyladenine N6-Isopentenyladenosine N6-ISOPENTENYLADENOSINE-D6 NCGC00253650-01 N-Isopentenyladenosine NS00037896 NSC 105546 NSC-105546 N(sup 6)-(2-Isopentenyl)adenosine N(sup 6)-(delta(sup 2)-Isopentenyl)adenosine N(sup 6)-Dimethylallyladenosine N(sup 6)-Isopentenyladenosine Q973089 Riboprin Riboprina Riboprina [INN-Spanish] Riboprine Riboprine (USAN/INN) Riboprine [USAN:INN] Riboprinum Riboprinum [INN-Latin] Ribosyl-deoxyzeatin SB19217 SCHEMBL4599 SQ 22,558 SQ 22558 SR-01000883994 SR-01000883994-1 Tox21_113776 UNII-8EU82FAZ5J USVMJSALORZVDV-SDBHATRESA-N ZB001990 ZINC57125 ZIR ZK 20 242 |
| Nature of the modified residue | Natural |
| RNAMods code | + |
| Residue unique ID | 56 |
| Found in RNA | Yes |
| Related nucleotides | 253 |
| Enzymes |
MiaA (Escherichia coli) Mod5 (Saccharomyces cerevisiae) Mod5 (Arabidopsis thaliana) Mod5 (Homo sapiens) |
| Found in phylogeny | Eubacteria, Eukaryota |
| Found naturally in RNA types | tRNA |
Chemical information
| Sum formula | C15H21N5O4 |
| Type of moiety | nucleoside |
| Degeneracy | not applicable |
| PubChem ID | 266767 |
| SMILES | CC(C)=CCNc1ncnc2c1nc[n]2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |
| logP | -0.1111 |
| TPSA | 125.55 |
| Number of atoms | 24 |
| Number of Hydrogen Bond Acceptors 1 (HBA1) | 8 |
| Number of Hydrogen Bond Acceptors 2 (HBA2) | 9 |
| Number of Hydrogen Bond Donors (HBD) | 4 |
| PDB no exac match , link to the most similar ligand | ZIR |
| PDB exact match , link to the most similar ligand | ZIR |
| HMDB (Human Metabolome Database) no exact match, link to the most similar ligand | None |
| InChI | InChI=1S/C15H21N5O4/c1-8(2)3-4-16-13-10-14(18-6-17-13)20(7-19-10)15-12(23)11(22)9(5-21)24-15/h3,6-7,9,11-12,15,21-23H,4-5H2,1-2H3,(H,16,17,18)/t9-,11-,12-,15-/m1/s1 |
| InChIKey | USVMJSALORZVDV-SDBHATRESA-N |
| Search the molecule in external databases | ChEMBL ChemAgora ChEBI PubChem Compound Database Ligand Expo ChemSpider WIPO |
| PubChem CID | |
| PubChem SIDs |
8167815
14900019 29291476 47205724 47207387 49865122 57331696 57394611 78719788 103590441 104359861 126522890 129415601 135268870 135685507 162092682 163848518 163883871 170466472 175267107 179293602 223435363 223456059 223520354 226396566 241145216 250042075 252366704 252469406 255436967 255533163 275414349 275916385 297451252 300405780 310271989 312242592 315686148 316892507 316970942 319079543 321935077 321947307 329857546 340586333 341106025 341192239 341845564 342526852 347659363 347828260 348352524 349307660 355189941 355206239 363602844 373859701 374090770 375197713 375300403 375664678 376127092 378134810 381006330 381343820 381943907 383452077 385018319 385639495 386633707 387161596 403572053 404634097 404757794 404828194 405043690 405113193 406527754 419562373 434695877 438811058 439432506 441561228 442067933 442077650 442835331 |
* Chemical properties calculated with Open Babel - O'Boyle et al. Open Babel: An open chemical toolbox. J Cheminform 3, 33 (2011) (link)
Download Structures
| 2D | .png .mol .mol2 .sdf .pdb .smi |
| 3D | .mol .mol2 .sdf .pdb |
Tautomers
| Tautomers SMILES |
CC(C)=CCNc1ncnc2c1ncn2C3OC(CO)C(O)C3O tautomer #0
CC(C)=CCNc1ncnc2c1ncn2C3OC(CO)C(O)C3O tautomer #1 CC(C)=CCN=c1nc[nH]c2c1ncn2C3OC(CO)C(O)C3O tautomer #2 CC(C)=CCN=c1[nH]cnc2c1ncn2C3OC(CO)C(O)C3O tautomer #3 CC(C)=CCN=C1N=CN=C2C1N=CN2C3OC(CO)C(O)C3O tautomer #4 |
| Tautomer image | Show Image |
Predicted CYP Metabolic Sites
| CYP3A4 | CYP2D6 | CYP2C9 |
|---|---|---|
|
|
|
* CYP Metabolic sites predicted with SMARTCyp. SMARTCyp is a method for prediction of which sites in a molecule that are most liable to metabolism by Cytochrome P450. It has been shown to be applicable to metabolism by the isoforms 1A2, 2A6, 2B6, 2C8, 2C19, 2E1, and 3A4 (CYP3A4), and specific models for the isoform 2C9 (CYP2C9) and isoform 2D6 (CYP2D6). CYP3A4, CYP2D6, and CYP2C9 are the three of the most important enzymes in drug metabolism since they are involved in the metabolism of more than half of the drugs used today. The three top-ranked atoms are highlighted. See: SmartCYP and SmartCYP - background; Patrik Rydberg, David E. Gloriam, Lars Olsen, The SMARTCyp cytochrome P450 metabolism prediction server, Bioinformatics, Volume 26, Issue 23, 1 December 2010, Pages 2988–2989 (link)
LC-MS Information
| Monoisotopic mass | 335.1594 |
| Average mass | 335.358 |
| [M+H]+ | 336.1672 |
| Product ions | 204/136/148 |
| Normalized LC elution time * | 3,24 (Kellner 2014) |
| LC elution order/characteristics | after m6A (Kellner 2014) |
* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.
LC-MS Publications
| Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|
| Profiling of RNA modifications by multiplexed stable isotope labelling. | Kellner S, Neumann J, Rosenkranz D, Lebedeva S, Ketting RF, Zischler H, Schneider D, Helm M. | Chem Commun (Camb). | [details] | 24567952 | - |
| Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. | Su D, Chan CT, Gu C, Lim KS, Chionh YH, McBee ME, Russell BS, Babu IR, Begley TJ, Dedon PC... | Nat Protoc | [details] | 24625781 | - |
Chemical groups contained
| Type | Subtype |
|---|---|
| other | isopentenyl |
Reactions producing N6-isopentenyladenosine
| Name |
|---|
| A:i6A |
Reactions starting from N6-isopentenyladenosine
| Name |
|---|
| i6A:io6A |
| i6A:ms2i6A |
Last modification of this entry: Sept. 22, 2023