ID Card:
Full name:
tRNA (cytidine/uridine/adenosine-2'-O-)-methyltransferase TrmJ
Synonym:
PA14_14692
UniProt:
A0A0H2ZF87
Structures:
|
5GMC |
5GMB |
5GM8 |
Enzyme type:
Position of modification - modification:
t :None - Cm t :None - Um t :None - Am
Level of experimental evidence:
3
Level of experimental reliability:
3
PDB Structures:
5GMC
5GMB
5GM8
}
5GMC
Structure Description:
Abstract of the PDB Structure's related Publication:
Download RCSB-PDB Structures:
Protein sequence:
MLDRIRVVLVNTSHPGNIGGAARAMKNMGLSQLVLVQPESFPHGDAVARASGATDILDAARVVDTLEEALSGCSVVLGTSARDRRIPWPLLDPRECATTCLEHLEANGEVALVFGREYAGLTNEELQRCQFHVHIPSDPEFGSLNLAAAVQVLTYEVRMAWLAAQGKPTKMEKFESTSMLNTELVTADELELYYAHLERTLIDIGFLDPEKPRHLMSRLRRLYGRSAISKLEMNILRGILTETQKVARGLSYKRSDD
Comments:
Catalyzes the formation of 2'O-methylated cytidine (Cm32), 2'O-methylated uridine (Um32) or 2'O-methylated adenosine (Am32) at position 32 in tRNA. Confers resistance to oxidative stress.
Reaction
Substrate
SubstrateType
Position
(Anti)Codon
Modified (Anti)Codon
Amino Acid Change
Transcript Name
Transcript Region
Cellular Localization
References
C:Cm
tRNA (t)
tRNA/tRNA/prokaryotic cytosol
32
U:Um
tRNA (t)
tRNA/tRNA/prokaryotic cytosol
32
A:Am
tRNA (t)
tRNA/tRNA/prokaryotic cytosol
32
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa.
Sun J; Wu J; Yuan Y; Fan L; Chua WLP; Ling YHS; Balamkundu S; Chay HSS; Begley TJ; de Crécy-Lagard V; Dziergowska A; Dedon PC
Nucleic Acids Res
[details]
40716780
10.1093/nar/gkaf696