ID Card:
Full name:
tRNA-2′-O-methyltransferase TRM13
GI:
6324447
Orf:
YOL125w
COG:
COG2230
UniProt:
Q12383
Alpha Fold Predicted Structure:
AF-Q12383-F1
Enzyme type:
methyltransferase
Position of modification - modification:
t :4 - Am t :4 - Cm
Protein sequence:
MLQDNNGPAVKRAKPSERLQCEYFMEKKKRRCGMTRSSQNLYCSEHLNLMKKAANSQVHNKNGSEAEKERERVPCPLDPNHTVWADQLKKHLKKCNKTKLSHLNDDKPYYEPGYNGENGLLSSSVKIDITAEHLVQSIELLYKVFEGESMDELPLRQLNNKLMSLKRFPQLPSNTKHAVQQSSLIENLVDAGAFERPESLNFIEFGCGRAEFSRYVSLYLLTQLTSLPAEHSGSNSNEFVLIDRATNRMKFDKKIKDDFSEIKSNSPSKPISCPSIKRIKIDIRDLKMDPILKSTPGDDIQYVCISKHLCGVATDLTLRCIGNSSILHGDDNNGCNPKLKAICIAMCCRHVCDYGDYVNRSYVTSLVEKYRAHGSILTYETFFRVLTKLCSWGTCGRKPGTAITDIVNVVESFEGAEPYTITIKERENIGLMARRVIDEGRLVYVKEKFTEFNAELIRYVESDVSLENVAMLVYKK
Comments:
The enzyme and the modification position is conserved in eukaryotes.
Alpha Fold Predicted Structure:
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Protein sequence:
M
L
Q
D
N
N
G
P
A
V
K
R
A
K
P
S
E
R
L
Q
C
E
Y
F
M
E
K
K
K
R
R
C
G
M
T
R
S
S
Q
N
L
Y
C
S
E
H
L
N
L
M
K
K
A
A
N
S
Q
V
H
N
K
N
G
S
E
A
E
K
E
R
E
R
V
P
C
P
L
D
P
N
H
T
V
W
A
D
Q
L
K
K
H
L
K
K
C
N
K
T
K
L
S
H
L
N
D
D
K
P
Y
Y
E
P
G
Y
N
G
E
N
G
L
L
S
S
S
V
K
I
D
I
T
A
E
H
L
V
Q
S
I
E
L
L
Y
K
V
F
E
G
E
S
M
D
E
L
P
L
R
Q
L
N
N
K
L
M
S
L
K
R
F
P
Q
L
P
S
N
T
K
H
A
V
Q
Q
S
S
L
I
E
N
L
V
D
A
G
A
F
E
R
P
E
S
L
N
F
I
E
F
G
C
G
R
A
E
F
S
R
Y
V
S
L
Y
L
L
T
Q
L
T
S
L
P
A
E
H
S
G
S
N
S
N
E
F
V
L
I
D
R
A
T
N
R
M
K
F
D
K
K
I
K
D
D
F
S
E
I
K
S
N
S
P
S
K
P
I
S
C
P
S
I
K
R
I
K
I
D
I
R
D
L
K
M
D
P
I
L
K
S
T
P
G
D
D
I
Q
Y
V
C
I
S
K
H
L
C
G
V
A
T
D
L
T
L
R
C
I
G
N
S
S
I
L
H
G
D
D
N
N
G
C
N
P
K
L
K
A
I
C
I
A
M
C
C
R
H
V
C
D
Y
G
D
Y
V
N
R
S
Y
V
T
S
L
V
E
K
Y
R
A
H
G
S
I
L
T
Y
E
T
F
F
R
V
L
T
K
L
C
S
W
G
T
C
G
R
K
P
G
T
A
I
T
D
I
V
N
V
V
E
S
F
E
G
A
E
P
Y
T
I
T
I
K
E
R
E
N
I
G
L
M
A
R
R
V
I
D
E
G
R
L
V
Y
V
K
E
K
F
T
E
F
N
A
E
L
I
R
Y
V
E
S
D
V
S
L
E
N
V
A
M
L
V
Y
K
K
50 100 150 200 250 300 350 400 450 Sequence G H T B S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
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