Modomics - A Database of RNA Modifications

General Data

RNA Type tRNA
SOTerm SO:0000258
Original Source tdbD00005935
Secondary Structure (((((((..((((....[...)))).(((((.......))))).....(((((..]....))))))))))))....
Sequence (UNICHARACTER ENCODING) GCUCGUGUALCUCAGDGGDDAGAGCUPCGUGCUPAP6ACGCGACC7D?GUGGGTPCAѢUCCCCACCPCGAGCACCA
Sequence (SHORT NAMES ENCODING) GCUCGUGUApm2GCUCAGpDGGpDpDAGAGCUpYCGUGCUpYApYpt6AACGCGACCpm7GpDpm5CGUGGGpm5UpYCApm1AUCCCCACCpYCGAGCACCA
Sequence (MODOMICS CODE ENCODING) GCUCGUGUA2000002551GCUCAG2000008551UGG2000008551U2000008551UAGAGCU2000009551UCGUGCU2000009551UA2000009551U2000062551AACGCGACC2000007551G2000008551U2000005551CGUGGG2000005551U2000009551UCA2000001551AUCCCCACC2000009551UCGAGCACCA
Consensus Secondary Structure .(((((((..((((......[....)))).(((((.......)))))........................(((((..]....))))))))))))....
Alignment with Modification -GCUCGUGUALCUCAGD--GGDD-AGAGCUPCGUGCUPAP6ACGCGACC7D?-------------------GUGGGTPCAѢUCCCCACCPCGAGCACCA

Score Table

Table containing the score explanation. Score identify the level of experimental reliability and evidence so as exaplained in the 2023 release manuscript. Class 1 should be considered as highlyrelevant. Class 2 evidences are considered as Solid, namely large errors are unlikely and minor errors should not undermine the meaning of data. Class 3 is considered as speculative and errors are expected. Class 4 is considered as questionable. Class 5 evidence means that verification and data are still to be collected. Class 6 data cannot be estimated.
Method Classification Score
Multiple direct experimental evidence 1
Direct experimental evidence 2
Inferred based on indirect experimental evidence 3
Predicted computationally 4
Evidence not yet annotated (Unknown) 5
Irrelevant 6

RNA-2D Representation

RNA Secondary Structure

RNA Consensus Secondary Structure

Modification Positions

Table containing the original modifications present in the MODOMICS sequences. Edit locations not originally present in the RNA sequences are marked by their source. Their scores are in third row.

Position in the alignment 10 16 20 20A 27 34 36 37 45A 45B 45C 54 55 58 67
Position in the sequence 10 16 19 20 27 34 36 37 46 47 48 54 55 58 67
Modification positions m2G D D D Y Y Y t6A m7G D m5C m5U Y m1A Y
Source MODOMICS MODOMICS MODOMICS MODOMICS MODOMICS MODOMICS MODOMICS MODOMICS MODOMICS MODOMICS MODOMICS MODOMICS MODOMICS MODOMICS MODOMICS

Modification Annotation

Table containing the data present in the literature relating to the modification positions present in the RNA sequences. Some of the modified residuals may differ from the modifications originally present in MODOMICS. It follows the same format as the previous table. The table reports the scores that have been associated to the modified nucleotides so to have an estimation of the reliability of their presence.
Position in the alignment 10 16 20 20A 27 34 36 37 45A 45B 45C 54 55 58 67
Position in the sequence 10 16 19 20 27 34 36 37 46 47 48 54 55 58 67
Source: 7925304 m2G D D D Y Y Y t6A m7G D m5C m5U Y m1A Y
Level of Experimental Reliability 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
Level of Experimental Evidence 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3