Summary:

Name	Leukemia (N:Nm)
Description	Loss of 2'-O-Me results in decreased leukemia self-renewal potential and reduced colony formation potential.
Related RNA reaction	N:Nm
Found in RNA	rRNA
Modified Transcript	18S rRNA (C1703 and G1328)
Mapping Technology
Quantification techniques	RT-qPCR

Enzymes connected to Leukemia:

Acronym	Full name	Enzyme Role	Organism	Comment
DDX21	DExD-box helicase 21	oncogene	Homo sapiens
FBL	rRNA 2′-O-methyltransferase fibrillarin	oncogene	Homo sapiens
TLE5	TLE family member 5, transcriptional modulator	oncogene	Homo sapiens

Publications:

ID	Title	Authors	Journal	Details	PubMed Id	DOI
1060	AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.	Yi Liu,Christian Rohde,Cornelius Pauli,Dennis Gerloff,Marcel Köhn,Danny Misiak,Nicole Bäumer,Chunhong Cui,Stefanie Göllner,Thomas Oellerich,Hubert Serve,Maria-Paz Garcia-Cuellar,Robert Slany,Jaroslaw P Maciejewski,Bartlomiej Przychodzen,Barbara Seliger,Hans-Ulrich Klein,Christoph Bartenhagen,Wolfgang E Berdel,Martin Dugas,Makoto Mark Taketo,Daneyal Farouq,Schraga Schwartz,Aviv Regev,Josée Hébert,Guy Sauvageau,Caroline Pabst,Stefan Hüttelmaier,	Nat Cell Biol	[details]	28650479	10.1038/ncb3563