Summary:

NameLeukemia (xX:Xm)
DescriptionLoss of 2'-O-Me results in decreased leukemia self-renewal potential and reduced colony formation potential.
Related RNA reactionxX:Xm
Found in RNArRNA
Modified Transcript18S rRNA (C1703 and G1328)
Mapping Technology
Quantification techniquesRT-qPCR

Enzymes connected to this disease:

Acronym Full name Enzyme Role Organism
DDX21 DExD-box helicase 21 oncogene Homo sapiens
FBL rRNA 2′-O-methyltransferase fibrillarin oncogene Homo sapiens
TLE5 TLE family member 5, transcriptional modulator oncogene Homo sapiens
 

Publications:

ID Title Authors Journal Details PubMed Id DOI
1060 AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia. Fengbiao Zhou Nat Cell Biol [details] 28650479 10.1038/ncb3563

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