| RNA editing on ARPIN promotes the disease risk and is closely associated with type 2 Diabetes |
A:I
| Type 2 Diabetes |
| The reduced editing at the R/G site of glutamate receptor subunits (GluRs) is likely to reduce post-synaptic excitatory responses to glutamate, thus duce post-synaptic excitatory responses to glutamate, thus limiting the progression of cell death. |
A:I
| Spinal Cord Injury |
| RNA editing in GluR-B is essential for brain development to avoid the alteration of calcium permeability which affects mice seizure and survival |
A:I
| Severe epilepsy |
| RNA editing inhibits the enzymatic activity of TPH2 splice variants |
C:U
| Psychiatric disorders |
| 5HT2C editing is altered in individuals suffering from psychiatric disorders |
A:I
| Psychiatric disorders |
| RNA editing repairs the PINK1 W437amber mutation rescue the PINK1/Parkin-mediated mitophagy |
A:I
| Parkinson |
| Alu-dependent RNA editing of GLI1 promotes malignant regeneration in myeloma |
A:I
| Myeloma |
| ADAR has an oncogenic potential and the overexpression of the edited NEIL1 can enhance the growth and the invasion in the lung carcinoma |
A:I
| Lung cancer |
| Two over-editing sites (Q103R and K96R) of CDK13, modified by ADAR, are more abundant in HCC tumor tissues and are associated with poor prognosis of HCC patients |
A:I
| Hepatocellular carcinoma |
| Hypo-editing of COPA is closely associated with HCC pathogenesis and ADAR2 downregulation increased risk of liver cirrhosis and postoperative recurrence and had poor prognoses |
A:I
| Hepatocellular carcinoma |
| The editing of FLNB is responsible for the ADAR-induced malignant phenotypes during ESCC progression |
A:I
| Hepatocellular carcinoma |
| RNA editing increases and neutralizes a key inhibitor of the polyamine synthesis pathway, thereby promoting proliferation in vitro and increasing tumor initiation and is asscoaited with liver cirrhosis |
A:I
| Hepatocellular carcinoma |
| The over-editing at the COG3 I/V site plays a critical pro-tumoral role in GBM and correlates with a worse prognosis in GBM patients |
A:I
| Glioblastoma |
| Anti-tumoral: reduction of maturation of oncogenic precursors |
C:U
| Glioblastoma |
| Deficiency of RNA editing in Q/R site of the GluA2 induces the loss of Ca2+ homeostasis associated with early onset epilepsy and premature death |
A:I
| Glioblastoma |
| A-to-I RNA editing of the SLC22A3 gene is associated with the reduced SLC22A3 transcription and lymph node metastasis |
A:I
| Esophageal squamous cell carcinoma |
| Hyper-editing of FLNB is closely associated with HCC pathogenesis and ADAR overexpression increased risk of liver cirrhosis and postoperative recurrence and had poor prognoses |
A:I
| Esophageal squamous cell carcinoma |
| ADAR2 suppresses tumor growth and induces apoptosis by editing and stabilizing IGFBP7 in ESCC |
A:I
| Esophageal squamous cell carcinoma |
| RNA editing inhibits the enzymatic activity of TPH2 splice variants |
A:I
| Depression disorder |
| RNA editing inhibits the enzymatic activity of TPH2 splice variants |
C:U
| Depression disorder |
| RNA editing inhibits the enzymatic activity of TPH2 splice variants |
A:I
| Depression disorder |
| RNA editing inhibits the enzymatic activity of TPH2 splice variants |
C:U
| Depression disorder |
| Edited form of RhoQ protein plays an important role in promoting the invasive potential of CRC |
A:I
| Colorectal cancer |
| Increased IFN-γ pathway gene expression |
A:I
| Chronic Myeloid Leukemia |
| The two edited forms of BLCAP fail to inhibit STAT3 phosphorylation indicating that A-to-I RNA editing drive anti-tumorigenic BLCAP to a loss-of-function one which might facilitate the cervical cancer initiating and progressing events |
A:I
| Cervical cancer |
| RNA ‐editing of Filamin A pre‐mRNA is decreased in human cardiac disease |
A:I
| Cardiac Disease |
| ADAR expression is higher in tumor compared to patient-matched normal breast tissues and cell proliferation is correlated to its activity |
A:I
| Breast cancer |
| hV1.1 recoded by editing (Ile400) is altered in the intracellular side of the selectivity filter |
A:I
| Behavioral and neurological consequences |
| RNA-editing enzyme ADAR2 occurs in the majority of ALS cases and causes the death of motor neurons |
A:I
| Amiothrophic Lateral Sclerosis |
| Deficiency of RNA editing in Q/R site of the GluA2 induces the loss of Ca2+ homeostasis associated with early onset epilepsy and premature death |
A:I
| Alzheimer |
| ADAR acts as a suppressor of type I interferon signaling |
A:I
| Aicardi-Goutières syndrome |
| Splicing mutations affecting either the SH2 or PTPase domain of SHP-1 in motheaten and viable motheaten mice lead to multiple hematopoietic abnormalities, including the overexpansion and accumulation of myelomonocytic populations |
A:I
| Acute Myeloid Leukemia |