Modomics - A Database of RNA Modifications

Reaction details:

Reaction type level 1: carboxymethylaminomethylation
Reaction type level 2: aminoalkylation
Reaction type level 3: group addition
Input group: H
Output group: *CNCC(=O)O
Introduced group name: carboxymethylaminomethyl
Introduced group type: aminoalkyl
Site: base/endocyclic
Atom address: C5
Modification level: 3

Enzymes that catalyse this reaction:

Acronym Full name Organism
MnmE tRNA uridine(34) 5-carboxymethylaminomethyl synthesis GTPase Escherichia coli
MnmE tRNA modification GTPase MnmE Chlorobium tepidum
MnmE tRNA modification GTPase MnmE Nostoc sp.
MnmE tRNA modification GTPase MnmE Thermotoga maritima
MnmG tRNA uridine(34) 5-carboxymethylaminomethyl synthesis enzyme Escherichia coli
MnmG tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG Chlorobium tepidum
MnmG tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG Aquifex aeolicus
 

Image with reaction


Image with reaction

Image with reaction

Publications

Title Authors Journal Details PubMed Id DOI
Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions. Moukadiri I, Prado S, Piera J, Velázquez-Campoy A, Björk GR, Armengod ME Nucleic Acids Res [details] 19767610 -