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July 1, 2003 |
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Oct. 1, 2004 |
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Jan. 1, 2007 |
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| Cysteine of sequence motif VI is essential for nucleophilic catalysis by yeast tRNA m5C methyltransferase. |
Walbott H, Husson C, Auxilien S, Golinelli-Pimpaneau B |
July 1, 2007 |
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Motorin Y, Keith G, Simon C, Foiret D, Simos G, Hurt E, Grosjean H |
July 1, 1998 |
| The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Psi-synthase also acting on tRNAs. |
Behm-Ansmant I, Urban A, Ma X, Yu YT, Motorin Y, Branlant C |
Nov. 1, 2003 |
| Aminoacylation of the anticodon stem by a tRNA-synthetase paralog: relic of an ancient code? |
Grosjean H, de Crecy-Lagard V, Bjork GR |
Oct. 1, 2004 |
| The Saccharomyces cerevisiae Pus2 protein encoded by YGL063w ORF is a mitochondrial tRNA:Psi27/28-synthase. |
Behm-Ansmant I, Branlant C, Motorin Y |
Oct. 1, 2007 |
| Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species. |
Kotelawala L, Grayhack EJ, Phizicky EM |
Feb. 1, 2008 |
| The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon. |
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Aug. 20, 2008 |
| IscS is a sulfurtransferase for the in vitro biosynthesis of 4-thiouridine in Escherichia coli tRNA. |
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Dec. 14, 1999 |
| Bioinformatic analyses of the tRNA: (guanine 26, N2,N2)-dimethyltransferase (Trm1) family. |
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July 1, 2002 |
| Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA. |
Purushothaman SK, Bujnicki JM, Grosjean H, Lapeyre B |
June 1, 2005 |
| Mechanistic investigations of the pseudouridine synthase RluA using RNA containing 5-fluorouridine. |
Hamilton CS, Greco TM, Vizthum CA, Ginter JM, Johnston MV, Mueller EG |
Oct. 3, 2006 |
| Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase. |
Bujnicki JM, Feder M, Radlinska M, Blumenthal RM |
Oct. 1, 2002 |
| Yeast NOP2 encodes an essential nucleolar protein with homology to a human proliferation marker. |
de Beus E, Brockenbrough JS, Hong B, Aris JP |
Dec. 1, 1994 |
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Feb. 16, 2004 |
| An essential yeast protein, CBF5p, binds in vitro to centromeres and microtubules. |
Jiang W, Middleton K, Yoon HJ, Fouquet C, Carbon J |
Aug. 1, 1993 |
| A truncated aminoacyl-tRNA synthetase modifies RNA. |
Salazar JC, Ambrogelly A, Crain PF, McCloskey JA, Soll D |
May 18, 2004 |
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Nov. 12, 2004 |
| A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase. |
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Jan. 1, 2004 |
| The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain. |
Hallberg BM, Ericsson UB, Johnson KA, Andersen NM, Douthwaite S, Nordlund P, Beuscher AE 4th, Erlandsen H |
July 21, 2006 |
| MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferase. |
Pintard L, Bujnicki JM, Lapeyre B, Bonnerot C |
March 1, 2002 |
| The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase. |
Caldas T, Binet E, Bouloc P, Costa A, Desgres J, Richarme G |
June 2, 2000 |
| Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1). |
Hausmann S, Shuman S |
Jan. 11, 2005 |
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May 1, 1988 |
| Purification, cloning, and properties of the 16S RNA pseudouridine 516 synthase from Escherichia coli. |
Wrzesinski J, Bakin A, Nurse K, Lane BG, Ofengand J |
July 11, 1995 |
| Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus. |
Mouaikel J, Verheggen C, Bertrand E, Tazi J, Bordonne R |
April 1, 2002 |
| The Escherichia coli trmE (mnmE) gene, involved in tRNA modification, codes for an evolutionarily conserved GTPase with unusual biochemical properties. |
Cabedo H, Macian F, Villarroya M, Escudero JC, Martinez-Vicente M, Knecht E, Armengod ME |
Dec. 15, 1999 |
| Analysis of sequence and structural features that identify the B/C motif of U3 small nucleolar RNA as the recognition site for the Snu13p-Rrp9p protein pair. |
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Jan. 1, 2007 |
| The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. |
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May 29, 1997 |
| A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. |
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July 1, 2005 |
| Biosynthesis of archaeosine, a novel derivative of 7-deazaguanosine specific to archaeal tRNA, proceeds via a pathway involving base replacement on the tRNA polynucleotide chain. |
Watanabe M, Matsuo M, Tanaka S, Akimoto H, Asahi S, Nishimura S, Katze JR, Hashizume T, Crain PF, McCloskey JA, Okada N |
Aug. 8, 1997 |
| Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage. |
Lapeyre B, Purushothaman SK |
Nov. 19, 2004 |
| Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop. |
Pintard L, Lecointe F, Bujnicki JM, Bonnerot C, Grosjean H, Lapeyre B |
April 2, 2002 |
| Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli. |
Agarwalla S, Kealey JT, Santi DV, Stroud RM |
March 15, 2002 |
| Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA. |
Massenet S, Motorin Y, Lafontaine DL, Hurt EC, Grosjean H, Branlant C |
March 1, 1999 |
| Genetic mapping and cloning of the gene (trmC) responsible for the synthesis of tRNA (mnm5s2U)methyltransferase in Escherichia coli K12. |
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Jan. 1, 1984 |
| Methyltransferase that modifies guanine 966 of the 16 S rRNA: functional identification and tertiary structure. |
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Jan. 23, 2007 |
| Novel methyltransferase for modified uridine residues at the wobble position of tRNA. |
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Dec. 1, 2003 |
| Crystal structure of Bacillus subtilis S-adenosylmethionine:tRNA ribosyltransferase-isomerase. |
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Dec. 22, 2006 |
| Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. |
Noma A, Kirino Y, Ikeuchi Y, Suzuki T |
May 17, 2006 |
| Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast. |
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Nov. 1, 2003 |
| MSS1, a nuclear-encoded mitochondrial GTPase involved in the expression of COX1 subunit of cytochrome c oxidase. |
Decoster E, Vassal A, Faye G |
July 5, 1993 |
| Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli. |
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March 30, 1999 |
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Del Campo M, Kaya Y, Ofengand J |
Nov. 1, 2001 |
| A new function of S-adenosylmethionine: the ribosyl moiety of AdoMet is the precursor of the cyclopentenediol moiety of the tRNA wobble base queuine. |
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Aug. 3, 1993 |
| An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA. |
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Sept. 1, 2003 |
| The yggH gene of Escherichia coli encodes a tRNA (m7G46) methyltransferase. |
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May 1, 2003 |
| Evidence for natural gene transfer from gram-positive cocci to Escherichia coli. |
Brisson-Noel A, Arthur M, Courvalin P |
April 1, 1988 |
| The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot. |
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Oct. 1, 2002 |
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Watanabe K, Nureki O, Fukai S, Endo Y, Hori H |
Nov. 10, 2006 |
| Deletion of the Escherichia coli pseudouridine synthase gene truB blocks formation of pseudouridine 55 in tRNA in vivo, does not affect exponential growth, but confers a strong selective disadvantage in competition with wild-type cells. |
Gutgsell N, Englund N, Niu L, Kaya Y, Lane BG, Ofengand J |
Dec. 1, 2000 |
| The conserved Cys-X1-X2-Cys motif present in the TtcA protein is required for the thiolation of cytidine in position 32 of tRNA from Salmonella enterica serovar Typhimurium. |
Jager G, Leipuviene R, Pollard MG, Qian Q, Bjork GR |
Jan. 1, 2004 |
| Sequence-structure-function studies of tRNA:m5C methyltransferase Trm4p and its relationship to DNA:m5C and RNA:m5U methyltransferases. |
Bujnicki JM, Feder M, Ayres CL, Redman KL |
Jan. 1, 2004 |
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Hagervall TG, Edmonds CG, McCloskey JA, Bjork GR |
June 25, 1987 |
| Mechanism and substrate specificity of tRNA-guanine transglycosylases (TGTs): tRNA-modifying enzymes from the three different kingdoms of life share a common catalytic mechanism. |
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Nov. 1, 2005 |
| The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. |
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May 29, 1997 |
| GCD14p, a repressor of GCN4 translation, cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces cerevisiae. |
Calvo O, Cuesta R, Anderson J, Gutierrez N, Garcia-Barrio MT, Hinnebusch AG, Tamame M |
June 1, 1999 |
| Isolation and characterization of the yeast mRNA capping enzyme beta subunit gene encoding RNA 5'-triphosphatase, which is essential for cell viability. |
Tsukamoto T, Shibagaki Y, Imajoh-Ohmi S, Murakoshi T, Suzuki M, Nakamura A, Gotoh H, Mizumoto K |
Oct. 9, 1997 |
| Substitutions in an active site loop of Escherichia coli IscS result in specific defects in Fe-S cluster and thionucleoside biosynthesis in vivo. |
Lauhon CT, Skovran E, Urbina HD, Downs DM, Vickery LE |
May 7, 2004 |
| A second function for pseudouridine synthases: A point mutant of RluD unable to form pseudouridines 1911, 1915, and 1917 in Escherichia coli 23S ribosomal RNA restores normal growth to an RluD-minus strain. |
Gutgsell NS, Del Campo M, Raychaudhuri S, Ofengand J |
July 1, 2001 |
| Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae. |
Kressler D, Rojo M, Linder P, Cruz J |
Dec. 1, 1999 |
| The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA. |
Toh SM, Xiong L, Bae T, Mankin AS |
Feb. 1, 2008 |
| Identification of Escherichia coli m2G methyltransferases: I. the ycbY gene encodes a methyltransferase specific for G2445 of the 23 S rRNA. |
Lesnyak DV, Sergiev PV, Bogdanov AA, Dontsova OA |
Nov. 17, 2006 |
| The GTPase activity and C-terminal cysteine of the Escherichia coli MnmE protein are essential for its tRNA modifying function. |
Yim L, Martinez-Vicente M, Villarroya M, Aguado C, Knecht E, Armengod ME |
Aug. 1, 2003 |
| tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli. |
Wolf J, Gerber AP, Keller W |
July 15, 2002 |
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June 26, 1998 |
| Roles of conserved amino acid sequence motifs in the SpoU (TrmH) RNA methyltransferase family. |
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Sept. 1, 1988 |
| Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs. |
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Nov. 11, 2005 |
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July 1, 2005 |
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Dec. 1, 2002 |
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May 15, 2005 |
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Gustafsson C, Persson BC |
Feb. 1, 1998 |
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March 1, 2006 |
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June 1, 2007 |
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April 23, 2004 |
| The RNA Modification Database: 1999 update. |
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Feb. 1, 1999 |
| Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme. |
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Oct. 1, 2005 |
| The Escherichia coli YadB gene product reveals a novel aminoacyl-tRNA synthetase like activity. |
Campanacci V, Dubois DY, Becker HD, Kern D, Spinelli S, Valencia C, Pagot F, Salomoni A, Grisel S, Vincentelli R, Bignon C, Lapointe J, Giege R, Cambillau C |
March 19, 2004 |
| Identification of the tRNA-dihydrouridine synthase family. |
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July 12, 2002 |
| An adenosine deaminase that generates inosine at the wobble position of tRNAs. |
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Nov. 5, 1999 |
| Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain. |
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| The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. |
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| The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs. |
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Blaise M, Becker HD, Lapointe J, Cambillau C, Giege R, Kern D |
Sept. 1, 2005 |
| Further insights into the tRNA modification process controlled by proteins MnmE and GidA of Escherichia coli. |
Yim L, Moukadiri I, Bjork GR, Armengod ME |
Jan. 1, 2006 |
| A unique RNA Fold in the RumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function. |
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March 11, 2005 |
| Crystal structure of IscA, an iron-sulfur cluster assembly protein from Escherichia coli. |
Cupp-Vickery JR, Silberg JJ, Ta DT, Vickery LE |
April 16, 2004 |
| The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo. |
Nasvall SJ, Chen P, Bjork GR |
Oct. 1, 2004 |
| The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. |
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May 29, 1997 |
| Identification of the miaB gene, involved in methylthiolation of isopentenylated A37 derivatives in the tRNA of Salmonella typhimurium and Escherichia coli. |
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Dec. 1, 1999 |
| Iron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin. |
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June 22, 2001 |
| Sequence analysis and structure prediction of 23S rRNA:m1G methyltransferases reveals a conserved core augmented with a putative Zn-binding domain in the N-terminus and family-specific elaborations in the C-terminus. |
Bujnicki JM, Blumenthal RM, Rychlewski L |
Feb. 1, 2002 |
| Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs. |
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Dec. 1, 1998 |
| GAR1 is an essential small nucleolar RNP protein required for pre-rRNA processing in yeast. |
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May 15, 2005 |
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Oct. 1, 2002 |
| The coiled-coil domain of the Nop56/58 core protein is dispensable for sRNP assembly but is critical for archaeal box C/D sRNP-guided nucleotide methylation. |
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June 1, 2006 |
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Dec. 1, 2000 |
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Aug. 1, 2005 |
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May 1, 2000 |
| In silico analysis of the tRNA:m1A58 methyltransferase family: homology-based fold prediction and identification of new members from Eubacteria and Archaea. |
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Oct. 26, 2001 |
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| The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4. |
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Nov. 1, 2000 |
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| Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA. |
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Oct. 5, 2007 |
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July 1, 1997 |
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Nov. 4, 1994 |
| The crystal structure of E. coli rRNA pseudouridine synthase RluE. |
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April 13, 2007 |
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May 18, 2004 |
| Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: essential elements for recognition of tRNA substrates within the anticodon stem-loop. |
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May 30, 2000 |
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| How U38, 39, and 40 of many tRNAs become the targets for pseudouridylation by TruA. |
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April 27, 2007 |
| Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. |
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Feb. 16, 1998 |
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April 3, 2002 |
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Hecker A, Graille M, Madec E, Gadelle D, Le Cam E, van Tilbergh H, Forterre P |
Jan. 1, 2009 |
| The activity of an ancient atypical protein kinase is stimulated by ADP-ribose in vitro. |
Haile JD, Kennelly PJ |
July 1, 2011 |
| Structure-function analysis of yeast piD261/Bud32, an atypical protein kinase essential for normal cell life. |
Facchin S, Lopreiato R, Stocchetto S, Arrigoni G, Cesaro L, Marin O, Carignani G, Pinna LA |
June 1, 2002 |
| Cbf5p, the putative pseudouridine synthase of H/ACA-type snoRNPs, can form a complex with Gar1p and Nop10p in absence of Nhp2p and box H/ACA snoRNAs. |
Henras AK, Capeyrou R, Henry Y, Caizergues-Ferrer M |
Nov. 1, 2004 |
| Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA. |
Liang B, Zhou J, Kahen E, Terns RM, Terns MP, Li H |
July 1, 2009 |
| Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. |
Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, Durocher D, Sicheri F |
Oct. 24, 2008 |
| A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. |
Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D |
March 24, 2006 |
| Active site mapping and substrate specificity of bacterial Hen1, a manganese-dependent 3' terminal RNA ribose 2'O-methyltransferase. |
Jain R, Shuman S |
March 1, 2011 |
| Structural and biochemical insights into 2'-O-methylation at the 3'-terminal nucleotide of RNA by Hen1. |
Mui Chan C, Zhou C, Brunzelle JS, Huang RH |
Oct. 20, 2009 |
| Bacterial Hen1 is a 3' terminal RNA ribose 2'-O-methyltransferase component of a bacterial RNA repair cassette. |
Jain R, Shuman S |
Jan. 1, 2010 |
| Probing the substrate specificity of the bacterial Pnkp/Hen1 RNA repair system using synthetic RNAs. |
Zhang C, Chan CM, Wang P, Huang RH |
Jan. 1, 2012 |
| Reconstituting bacterial RNA repair and modification in vitro. |
Chan CM, Zhou C, Huang RH |
Oct. 9, 2009 |
| An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro. |
Hecker A, Leulliot N, Gadelle D, Graille M, Justome A, Dorlet P, Brochier C, Quevillon-Cheruel S, Le Cam E, van Tilbeurgh H, Forterre P |
Jan. 1, 2007 |
| The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. |
Srinivasan M, Mehta P, Yu Y, Prugar E, Koonin EV, Karzai AW, Sternglanz R |
March 2, 2011 |
| A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification. |
El Yacoubi B, Hatin I, Deutsch C, Kahveci T, Rousset JP, Iwata-Reuyl D, Murzin AG, de Crecy-Lagard V |
March 2, 2011 |
| Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs. |
Daugeron MC, Lenstra TL, Frizzarin M, El Yacoubi B, Liu X, Baudin-Baillieu A, Lijnzaad P, Decourty L, Saveanu C, Jacquier A, Holstege FC, de Crecy-Lagard V, van Tilbeurgh H, Libri D |
Aug. 1, 2011 |
| Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex. |
Hecker A, Lopreiato R, Graille M, Collinet B, Forterre P, Libri D, van Tilbeurgh H |
Sept. 3, 2008 |
| Functional characterization of the YmcB and YqeV tRNA methylthiotransferases of Bacillus subtilis. |
Anton BP, Russell SP, Vertrees J, Kasif S, Raleigh EA, Limbach PA, Roberts RJ |
Oct. 1, 2010 |
| MiaB, a bifunctional radical-S-adenosylmethionine enzyme involved in the thiolation and methylation of tRNA, contains two essential [4Fe-4S] clusters. |
Hernandez HL, Pierrel F, Elleingand E, Garcia-Serres R, Huynh BH, Johnson MK, Fontecave M, Atta M |
May 1, 2007 |
| MiaB protein from Thermotoga maritima. Characterization of an extremely thermophilic tRNA-methylthiotransferase. |
Pierrel F, Hernandez HL, Johnson MK, Fontecave M, Atta M |
Aug. 8, 2003 |
| S-Adenosylmethionine-dependent radical-based modification of biological macromolecules. |
Atta M, Mulliez E, Arragain S, Forouhar F, Hunt JF, Fontecave M |
Dec. 1, 2010 |
| Identification of a tRNA isopentenyltransferase gene from Arabidopsis thaliana. |
Golovko A, Sitbon F, Tillberg E, Nicander B |
May 1, 2002 |
| Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis. |
Miyawaki K, Tarkowski P, Matsumoto-Kitano M, Kato T, Sato S, Tarkowska D, Tabata S, Sandberg G, Kakimoto T |
Oct. 31, 2006 |
| Cloning of a human tRNA isopentenyl transferase. |
Golovko A, Hjalm G, Sitbon F, Nicander B |
Nov. 27, 2000 |
| Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. |
Arragain S, Handelman SK, Forouhar F, Wei FY, Tomizawa K, Hunt JF, Douki T, Fontecave M, Mulliez E, Atta M |
Sept. 10, 2010 |
| Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. |
Wei FY, Suzuki T, Watanabe S, Kimura S, Kaitsuka T, Fujimura A, Matsui H, Atta M, Michiue H, Fontecave M, Yamagata K, Suzuki T, Tomizawa K |
Sept. 1, 2011 |
| Backbone resonance assignments of the 48 kDa dimeric putative 18S rRNA-methyltransferase Nep1 from Methanocaldococcus jannaschii. |
Wurm JP, Duchardt E, Meyer B, Leal BZ, Kotter P, Entian KD, Wohnert J |
Dec. 1, 2009 |
| The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase. |
Wurm JP, Meyer B, Bahr U, Held M, Frolow O, Kotter P, Engels JW, Heckel A, Karas M, Entian KD, Wohnert J |
April 1, 2010 |
| Specificity shifts in the rRNA and tRNA nucleotide targets of archaeal and bacterial m5U methyltransferases. |
Auxilien S, Rasmussen A, Rose S, Brochier-Armanet C, Husson C, Fourmy D, Grosjean H, Douthwaite S |
Feb. 1, 2011 |
| Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance. |
Oberto J, Breuil N, Hecker A, Farina F, Brochier-Armanet C, Culetto E, Forterre P |
Sept. 1, 2009 |
| Interaction of the tylosin-resistance methyltransferase RlmA II at its rRNA target differs from the orthologue RlmA I. |
Douthwaite S, Jakobsen L, Yoshizawa S, Fourmy D |
May 16, 2008 |
| Recognition elements in rRNA for the tylosin resistance methyltransferase RlmA(II). |
Lebars I, Husson C, Yoshizawa S, Douthwaite S, Fourmy D |
Sept. 14, 2007 |
| The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748. |
Douthwaite S, Crain PF, Liu M, Poehlsgaard J |
April 9, 2004 |
| A single methyltransferase YefA (RlmCD) catalyses both m5U747 and m5U1939 modifications in Bacillus subtilis 23S rRNA. |
Desmolaize B, Fabret C, Bregeon D, Rose S, Grosjean H, Douthwaite S |
Nov. 1, 2011 |
| Cloning and characterization of the 23S RNA pseudouridine 2633 synthase from Bacillus subtilis. |
Niu L, Lane BG, Ofengand J |
Feb. 12, 1999 |
| Structural basis for binding of RNA and cofactor by a KsgA methyltransferase. |
Tu C, Tropea JE, Austin BP, Court DL, Waugh DS, Ji X |
March 11, 2009 |
| A mitochondrial rRNA dimethyladenosine methyltransferase in Arabidopsis. |
Richter U, Kuhn K, Okada S, Brennicke A, Weihe A, Borner T |
Jan. 1, 2010 |
| Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2. |
Cotney J, Shadel GS |
Nov. 1, 2006 |
| Binding of adenosine-based ligands to the MjDim1 rRNA methyltransferase: implications for reaction mechanism and drug design. |
O'Farrell HC, Musayev FN, Scarsdale JN, Rife JP |
March 30, 2010 |
| Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine. |
Demirci H, Belardinelli R, Seri E, Gregory ST, Gualerzi C, Dahlberg AE, Jogl G |
May 1, 2009 |
| Inactivation of KsgA, a 16S rRNA methyltransferase, causes vigorous emergence of mutants with high-level kasugamycin resistance. |
Ochi K, Kim JY, Tanaka Y, Wang G, Masuda K, Nanamiya H, Okamoto S, Tokuyama S, Adachi Y, Kawamura F |
Feb. 1, 2009 |
| Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. |
Demirci H, Larsen LH, Hansen T, Rasmussen A, Cadambi A, Gregory ST, Kirpekar F, Jogl G |
Aug. 1, 2010 |
| Crystal structure of the Thermus thermophilus 16 S rRNA methyltransferase RsmC in complex with cofactor and substrate guanosine. |
Demirci H, Gregory ST, Dahlberg AE, Jogl G |
Sept. 26, 2008 |
| Structural and functional characterization of Rv2966c protein reveals an RsmD-like methyltransferase from Mycobacterium tuberculosis and the role of its N-terminal domain in target recognition. |
Kumar A, Saigal K, Malhotra K, Sinha KM, Taneja B |
June 3, 2011 |
| Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG. |
Gregory ST, Demirci H, Belardinelli R, Monshupanee T, Gualerzi C, Dahlberg AE, Jogl G |
Sept. 1, 2009 |
| Crystal structure of Sulfolobus tokodaii Sua5 complexed with L-threonine and AMPPNP. |
Kuratani M, Kasai T, Akasaka R, Higashijima K, Terada T, Kigawa T, Shinkai A, Bessho Y, Yokoyama S |
July 1, 2011 |
| Crystal structure of tRNA adenosine deaminase (TadA) from Aquifex aeolicus. |
Kuratani M, Ishii R, Bessho Y, Fukunaga R, Sengoku T, Shirouzu M, Sekine S, Yokoyama S |
April 22, 2005 |
| Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA. |
Losey HC, Ruthenburg AJ, Verdine GL |
Jan. 1, 2006 |
| Sequence analysis and overexpression of the Zymomonas mobilis tgt gene encoding tRNA-guanine transglycosylase: purification and biochemical characterization of the enzyme. |
Reuter K, Ficner R |
Sept. 1, 1995 |
| Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange. |
Romier C, Reuter K, Suck D, Ficner R |
June 3, 1996 |
| Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase to elucidate the role of serine 103 for enzymatic activity. |
Gradler U, Ficner R, Garcia GA, Stubbs MT, Klebe G, Reuter K |
July 2, 1999 |
| Substrate tRNA recognition mechanism of a multisite-specific tRNA methyltransferase, Aquifex aeolicus Trm1, based on the X-ray crystal structure. |
Awai T, Ochi A, Ihsanawati, Sengoku T, Hirata A, Bessho Y, Yokoyama S, Hori H |
Oct. 7, 2011 |
| Aquifex aeolicus tRNA (N2,N2-guanine)-dimethyltransferase (Trm1) catalyzes transfer of methyl groups not only to guanine 26 but also to guanine 27 in tRNA. |
Awai T, Kimura S, Tomikawa C, Ochi A, Ihsanawati, Bessho Y, Yokoyama S, Ohno S, Nishikawa K, Yokogawa T, Suzuki T, Hori H |
July 31, 2009 |
| Crystal structure of tRNA N2,N2-guanosine dimethyltransferase Trm1 from Pyrococcus horikoshii. |
Ihsanawati, Nishimoto M, Higashijima K, Shirouzu M, Grosjean H, Bessho Y, Yokoyama S |
Nov. 21, 2008 |
| Crystal structure of Methanocaldococcus jannaschii Trm4 complexed with sinefungin. |
Kuratani M, Hirano M, Goto-Ito S, Itoh Y, Hikida Y, Nishimoto M, Sekine S, Bessho Y, Ito T, Grosjean H, Yokoyama S |
Aug. 20, 2010 |
| THUMP from archaeal tRNA:m22G10 methyltransferase, a genuine autonomously folding domain. |
Gabant G, Auxilien S, Tuszynska I, Locard M, Gajda MJ, Chaussinand G, Fernandez B, Dedieu A, Grosjean H, Golinelli-Pimpaneau B, Bujnicki JM, Armengaud J |
Jan. 1, 2006 |
| N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota. |
Armengaud J, Urbonavicius J, Fernandez B, Chaussinand G, Bujnicki JM, Grosjean H |
Aug. 27, 2004 |
| YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors. |
Benitez-Paez A, Villarroya M, Douthwaite S, Gabaldon T, Armengod ME |
Nov. 1, 2010 |
| The open reading frame TTC1157 of Thermus thermophilus HB27 encodes the methyltransferase forming N(2)-methylguanosine at position 6 in tRNA. |
Roovers M, Oudjama Y, Fislage M, Bujnicki JM, Versees W, Droogmans L |
April 1, 2012 |
| Conformational change of pseudouridine 55 synthase upon its association with RNA substrate. |
Phannachet K, Huang RH |
Jan. 1, 2004 |
| Conserved network of proteins essential for bacterial viability. |
Handford JI, Ize B, Buchanan G, Butland GP, Greenblatt J, Emili A, Palmer T |
Aug. 1, 2009 |
| Effects on transcription of mutations in ygjD, yeaZ, and yjeE genes, which are involved in a universal tRNA modification in Escherichia coli. |
Hashimoto C, Sakaguchi K, Taniguchi Y, Honda H, Oshima T, Ogasawara N, Kato J |
Nov. 1, 2011 |
| Structural analysis of the essential resuscitation promoting factor YeaZ suggests a mechanism of nucleotide regulation through dimer reorganization. |
Aydin I, Saijo-Hamano Y, Namba K, Thomas C, Roujeinikova A |
Jan. 1, 2011 |
| Structure of an essential bacterial protein YeaZ (TM0874) from Thermotoga maritima at 2.5 A resolution. |
Xu Q, McMullan D, Jaroszewski L, Krishna SS, Elsliger MA, Yeh AP, Abdubek P, Astakhova T, Axelrod HL, Carlton D, Chiu HJ, Clayton T, Duan L, Feuerhelm J, Grant J, Han GW, Jin KK, Klock HE, Knuth MW, Miller MD, Morse AT, Nigoghossian E, Okach L, Oommachen S, Paulsen J, Reyes R, Rife CL, van den Bedem H, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA |
Oct. 1, 2010 |
| The structure of the hypothetical protein smu.1377c from Streptococcus mutans suggests a role in tRNA modification. |
Fu TM, Liu X, Li L, Su XD |
July 1, 2010 |
| The ATPase activity of an 'essential' Bacillus subtilis enzyme, YdiB, is required for its cellular function and is modulated by oligomerization. |
Karst JC, Foucher AE, Campbell TL, Di Guilmi AM, Stroebel D, Mangat CS, Brown ED, Jault JM |
March 1, 2009 |
| Known bioactive small molecules probe the function of a widely conserved but enigmatic bacterial ATPase, YjeE. |
Mangat CS, Brown ED |
Dec. 22, 2008 |
| Conserved P-loop GTPases of unknown function in bacteria: an emerging and vital ensemble in bacterial physiology. |
Brown ED |
Dec. 1, 2005 |
| The methyl group of the N6-methyl-N6-threonylcarbamoyladenosine in tRNA of Escherichia coli modestly improves the efficiency of the tRNA. |
Qian Q, Curran JF, Bjork GR |
April 1, 1998 |
| Biosynthesis of 7-deazaguanosine-modified tRNA nucleosides: a new role for GTP cyclohydrolase I. |
Phillips G, El Yacoubi B, Lyons B, Alvarez S, Iwata-Reuyl D, de Crecy-Lagard V |
Dec. 1, 2008 |
| The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps. |
McCarty RM, Somogyi A, Lin G, Jacobsen NE, Bandarian V |
May 12, 2009 |
| Genetic analysis identifies a function for the queC (ybaX) gene product at an initial step in the queuosine biosynthetic pathway in Escherichia coli. |
Gaur R, Varshney U |
Oct. 1, 2005 |
| Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase. |
McCarty RM, Somogyi A, Bandarian V |
March 24, 2009 |
| Functional promiscuity of the COG0720 family. |
Phillips G, Grochowski LL, Bonnett S, Xu H, Bailly M, Blaby-Haas C, El Yacoubi B, Iwata-Reuyl D, White RH, de Crecy-Lagard V |
Feb. 20, 2012 |
| Crystallization and preliminary X-ray characterization of queD from Bacillus subtilis, an enzyme involved in queuosine biosynthesis. |
Cicmil N, Shi L |
Jan. 1, 2008 |
| Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. |
Sekiya T, Adachi S, Kohu K, Yamada T, Higuchi O, Furukawa Y, Nakamura Y, Nakamura T, Tashiro K, Kuhara S, Ohwada S, Akiyama T |
Jan. 20, 2004 |
| Mechanistic studies of Bacillus subtilis QueF, the nitrile oxidoreductase involved in queuosine biosynthesis. |
Lee BW, Van Lanen SG, Iwata-Reuyl D |
Nov. 6, 2007 |
| Cloning and characterization of tRNA (m1A58) methyltransferase (TrmI) from Thermus thermophilus HB27, a protein required for cell growth at extreme temperatures. |
Droogmans L, Roovers M, Bujnicki JM, Tricot C, Hartsch T, Stalon V, Grosjean H |
April 15, 2003 |
| Crystal structure of Thermus thermophilus tRNA m1A58 methyltransferase and biophysical characterization of its interaction with tRNA. |
Barraud P, Golinelli-Pimpaneau B, Atmanene C, Sanglier S, Van Dorsselaer A, Droogmans L, Dardel F, Tisne C |
March 21, 2008 |
| Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase. |
Varshney U, Ramesh V, Madabushi A, Gaur R, Subramanya HS, RajBhandary UL |
Jan. 1, 2004 |
| Crystal structure of Rv2118c: an AdoMet-dependent methyltransferase from Mycobacterium tuberculosis H37Rv. |
Gupta A, Kumar PH, Dineshkumar TK, Varshney U, Subramanya HS |
Sept. 14, 2001 |
| Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. |
Pastore C, Topalidou I, Forouhar F, Yan AC, Levy M, Hunt JF |
Feb. 13, 2012 |
| Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. |
Fu D, Brophy JA, Chan CT, Atmore KA, Begley U, Paules RS, Dedon PC, Begley TJ, Samson LD |
May 1, 2010 |
| ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. |
van den Born E, Vagbo CB, Songe-Moller L, Leihne V, Lien GF, Leszczynska G, Malkiewicz A, Krokan HE, Kirpekar F, Klungland A, Falnes PO |
Jan. 1, 2011 |
| Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae. |
Noma A, Yi S, Katoh T, Takai Y, Suzuki T, Suzuki T |
June 1, 2011 |
| A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop. |
D'Silva S, Haider SJ, Phizicky EM |
June 1, 2011 |
| Crystal structure of Bacillus subtilis TrmB, the tRNA (m7G46) methyltransferase. |
Zegers I, Gigot D, van Vliet F, Tricot C, Aymerich S, Bujnicki JM, Kosinski J, Droogmans L |
Jan. 1, 2006 |
| Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding. |
Songe-Moller L, van den Born E, Leihne V, Vagbo CB, Kristoffersen T, Krokan HE, Kirpekar F, Falnes PO, Klungland A |
April 1, 2010 |
| An early step in wobble uridine tRNA modification requires the Elongator complex. |
Huang B, Johansson MJ, Bystrom AS |
April 1, 2005 |
| Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme. |
Yamada-Okabe T, Doi R, Shimmi O, Arisawa M, Yamada-Okabe H |
April 1, 1998 |
| Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme. |
Tsukamoto T, Shibagaki Y, Murakoshi T, Suzuki M, Nakamura A, Gotoh H, Mizumoto K |
Jan. 4, 1998 |
| Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. |
Pillutla RC, Yue Z, Maldonado E, Shatkin AJ |
Aug. 21, 1998 |
| Structure of the guanylyltransferase domain of human mRNA capping enzyme. |
Chu C, Das K, Tyminski JR, Bauman JD, Guan R, Qiu W, Montelione GT, Arnold E, Shatkin AJ |
June 21, 2011 |
| Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase. |
Tsukamoto T, Shibagaki Y, Niikura Y, Mizumoto K |
Oct. 9, 1998 |
| Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes. |
Saha N, Schwer B, Shuman S |
June 4, 1999 |
| Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-alpha. |
Wen Y, Shatkin AJ |
Dec. 1, 2000 |
| Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability. |
Shafer B, Chu C, Shatkin AJ |
April 1, 2005 |
| RAM/Fam103a1 is required for mRNA cap methylation. |
Gonatopoulos-Pournatzis T, Dunn S, Bounds R, Cowling VH |
Nov. 18, 2011 |
| Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways. |
Hausmann S, Zheng S, Costanzo M, Brost RL, Garcin D, Boone C, Shuman S, Schwer B |
Nov. 14, 2008 |
| Structure analysis of the conserved methyltransferase domain of human trimethylguanosine synthase TGS1. |
Monecke T, Dickmanns A, Strasser A, Ficner R |
April 1, 2009 |
| Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase. |
Belanger F, Stepinski J, Darzynkiewicz E, Pelletier J |
Oct. 22, 2010 |
| The human interferon-regulated ISG95 protein interacts with RNA polymerase II and shows methyltransferase activity. |
Haline-Vaz T, Silva TC, Zanchin NI |
Aug. 8, 2008 |
| Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1. |
Monecke T, Dickmanns A, Ficner R |
July 1, 2009 |
| 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. |
Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM |
June 1, 2011 |
| Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. |
Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Therien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B |
July 20, 2007 |
| A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP. |
Xue Y, Yang Z, Chen R, Zhou Q |
Feb. 1, 2010 |
| Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity. |
Gu M, Fabrega C, Liu SW, Liu H, Kiledjian M, Lima CD |
April 9, 2004 |
| The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. |
Liu H, Rodgers ND, Jiao X, Kiledjian M |
Sept. 2, 2002 |
| Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. |
Kwasnicka DA, Krakowiak A, Thacker C, Brenner C, Vincent SR |
Oct. 3, 2003 |
| Functional link between the mammalian exosome and mRNA decapping. |
Wang Z, Kiledjian M |
Dec. 14, 2001 |
| DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway. |
van Dijk E, Le Hir H, Seraphin B |
Oct. 14, 2003 |
| Functional analysis of mRNA scavenger decapping enzymes. |
Liu SW, Jiao X, Liu H, Gu M, Lima CD, Kiledjian M |
Sept. 1, 2004 |
| The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose. |
Treede I, Jakobsen L, Kirpekar F, Vester B, Weitnauer G, Bechthold A, Douthwaite S |
July 1, 2003 |
| Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes. |
Mosbacher TG, Bechthold A, Schulz GE |
May 23, 2003 |
| An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57. |
Weitnauer G, Gaisser S, Trefzer A, Stockert S, Westrich L, Quiros LM, Mendez C, Salas JA, Bechthold A |
March 1, 2001 |
| Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes. |
Mosbacher TG, Bechthold A, Schulz GE |
Feb. 21, 2005 |
| Sequence and properties of pIM13, a macrolide-lincosamide-streptogramin B resistance plasmid from Bacillus subtilis. |
Monod M, Denoya C, Dubnau D |
July 1, 1986 |
| Substrate requirements for ErmC' methyltransferase activity. |
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July 12, 2016 |
| Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3. |
Van Haute L, Dietmann S, Kremer L, Hussain S, Pearce SF, Powell CA, Rorbach J, Lantaff R, Blanco S, Sauer S, Kotzaeridou U, Hoffmann GF, Memari Y, Kolb-Kokocinski A, Durbin R, Mayr JA, Frye M, Prokisch H, Minczuk M |
June 30, 2017 |
| NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation. |
Haag S, Sloan KE, Ranjan N, Warda AS, Kretschmer J, Blessing C, Hübner B, Seikowski J, Dennerlein S, Rehling P, Rodnina MV, Höbartner C, Bohnsack MT |
Oct. 4, 2016 |
| Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. |
Chen YC, Kelly VP, Stachura SV, Garcia GA |
May 2, 2010 |
| A homozygous truncating mutation in PUS3 expands the role of tRNA modification in normal cognition. |
Shaheen R, Han L, Faqeih E, Ewida N, Alobeid E, Phizicky EM, Alkuraya FS |
July 1, 2016 |
| Identification of the methyltransferase targeting C2499 in Deinococcus radiodurans 23S ribosomal RNA. |
Mundus J, Flyvbjerg KF, Kirpekar F |
Nov. 21, 2015 |
| MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor. |
Zhong S, Li H, Bodi Z, Button J, Vespa L, Herzog M, Fray RG |
May 1, 2008 |
| Identification of factors required for m(6) A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI. |
Růžička K, Zhang M, Campilho A, Bodi Z, Kashif M, Saleh M, Eeckhout D, El-Showk S, Li H, Zhong S, De Jaeger G, Mongan NP, Hejátko J, Helariutta Y, Fray RG |
May 15, 2017 |
| Unique Features of the m6A Methylome in Arabidopsis thaliana |
Guan-Zheng Luo, Alice MacQueen, Guanqun Zheng, Hongchao Duan, Louis C Dore, Zhike Lu, Jun Liu, Kai Chen, Guifang Jia, Joy Bergelson, Chuan He |
Nov. 28, 2014 |
| Identification of 2-methylthio cyclic N6-threonylcarbamoyladenosine (ms2ct6A) as a novel RNA modification at position 37 of tRNAs |
Byeong-il Kang, Kenjyo Miyauchi, Michal Matuszewski, Gabriel Silveira D’Almeida, Mary Anne T. Rubio, Juan D. Alfonzo, Kazuki Inoue, Yuriko Sakaguchi, Takeo Suzuki, Elzbieta Sochacka, Tsutomu Suzuki |
Dec. 2, 2016 |
| Biochemical and Computational Analysis of the Substrate Specificities of Cfr and RlmN Methyltransferases |
Ntokou E, Hansen LH, Kongsted J, Vester B |
Dec. 23, 2015 |
| Structural and functional insights into tRNA binding and adenosine N1-methylation by an archaeal Trm10 homologue. |
Van Laer B, Roovers M, Wauters L, Kasprzak JM, Dyzma M, Deyaert E, Kumar Singh R, Feller A, Bujnicki JM, Droogmans L, Versées W |
Jan. 29, 2016 |
| Trm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased Translation |
Deng W, Babu IR, Su D, Yin S, Begley TJ, Dedon PC |
Dec. 15, 2015 |
| RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmAII in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithr |
Shoji T, Takaya A, Sato Y, Kimura S, Suzuki T, Yamamoto T |
Oct. 15, 2015 |
| tRNA recognition by a bacterial tRNA Xm32 modification enzyme from the SPOUT methyltransferase superfamily. |
Liu RJ, Long T, Zhou M, Zhou XL, Wang ED |
Sept. 3, 2015 |
| Identification of determinants for tRNA substrate recognition by Escherichia coli C/U34 2'-O-methyltransferase. |
Zhou M, Long T, Fang ZP, Zhou XL, Liu RJ, Wang ED |
June 24, 2015 |
| The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis. |
Zorbas C, Nicolas E, Wacheul L, Huvelle E, Heurgué-Hamard V, Lafontaine DL. |
June 1, 2015 |
| Hydroxylation of a conserved tRNA modification establishes non-universal genetic code in echinoderm mitochondria. |
Nagao A, Ohara M, Miyauchi K, Yokobori SI, Yamagishi A, Watanabe K, Suzuki T... |
Sept. 1, 2017 |
| A vastly increased chemical variety of RNA modifications that includes a thioacetal structure |
Dal Magro C, Keller P, Kotter A, Werner S, Duarte V, Marchand V, Ignarski M, Freiwald A, Müller RU, Dieterich C, Motorin Y, Butter F, Atta M, Helm M. |
April 6, 2018 |
| ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications. |
Kawarada L, Suzuki T, Ohira T, Hirata S, Miyauchi K, Suzuki T... |
July 7, 2017 |
| Purification and characterization of the human elongator complex. |
Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ... |
Feb. 25, 2002 |
| A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. |
Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL... |
Nov. 25, 2008 |
| Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells. |
Guzzi N, Ciesla M, Ngoc PCT, Lang S, Arora S, Dimitriou M, Pimkova K, Sommarin MNE, Munita R, Lubas M, Lim Y, Okuyama K, Soneji S, Karlsson G, Hansson J, Jonsson G, Lund AH, Sigvardsson M, Hellstrom-Lindberg E, Hsieh AC, Bellodi C... |
May 17, 2018 |
| A tRNA methyltransferase paralog is important for ribosome stability and cell division in Trypanosoma brucei. |
Fleming IM, Paris Z, Gaston KW, Balakrishnan R, Fredrick K, Rubio MA, Alfonzo JD... |
Jan. 18, 2016 |
| RNA editing by adenosine deaminases generates RNA and protein diversity. |
Schaub M, Keller W... |
Aug. 1, 2002 |
| A splice site mutation in the methyltransferase gene FTSJ1 in Xp11.23 is associated with non-syndromic mental retardation in a large Belgian family (MRX9). |
Ramser J, Winnepenninckx B, Lenski C, Errijgers V, Platzer M, Schwartz CE, Meindl A, Kooy RF... |
Sept. 1, 2004 |
| Mutations in the FTSJ1 gene coding for a novel S-adenosylmethionine-binding protein cause nonsyndromic X-linked mental retardation. |
Freude K, Hoffmann K, Jensen LR, Delatycki MB, des Portes V, Moser B, Hamel B, van Bokhoven H, Moraine C, Fryns JP, Chelly J, Gecz J, Lenzner S, Kalscheuer VM, Ropers HH... |
Aug. 1, 2004 |
| Solution structure of Urm1 and its implications for the origin of protein modifiers. |
Xu J, Zhang J, Wang L, Zhou J, Huang H, Wu J, Zhong Y, Shi Y... |
Aug. 1, 2006 |
| Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry. |
Matthies A, Nimtz M, Leimkuhler S... |
May 31, 2005 |
| Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation. |
Biederbick A, Stehling O, Rosser R, Niggemeyer B, Nakai Y, Elsasser HP, Lill R... |
Aug. 1, 2006 |
| Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells. |
Tong WH, Rouault T... |
Nov. 1, 2000 |
| Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7. |
Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N, Huang H, Laister R, Caudy AA, Gingras AC, Durocher D, Sicheri F... |
Feb. 25, 2017 |
| The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME. |
Costessi A, Mahrour N, Sharma V, Stunnenberg R, Stoel MA, Tijchon E, Conaway JW, Conaway RC, Stunnenberg HG... |
Jan. 1, 2012 |
| tRNA N6-adenosine threonylcarbamoyltransferase defect due to KAE1/TCS3 (OSGEP) mutation manifest by neurodegeneration and renal tubulopathy. |
Edvardson S, Prunetti L, Arraf A, Haas D, Bacusmo JM, Hu JF, Ta-Shma A, Dedon PC, de Crecy-Lagard V, Elpeleg O... |
May 1, 2017 |
| Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency. |
Facchin S, Lopreiato R, Ruzzene M, Marin O, Sartori G, Gotz C, Montenarh M, Carignani G, Pinna LA... |
Aug. 14, 2003 |
| Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. |
Abe Y, Matsumoto S, Wei S, Nezu K, Miyoshi A, Kito K, Ueda N, Shigemoto K, Hitsumoto Y, Nikawa J, Enomoto Y... |
Nov. 23, 2001 |
| Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein. |
Miyoshi A, Kito K, Aramoto T, Abe Y, Kobayashi N, Ueda N... |
April 4, 2003 |
| 2'-O-Methyl-5-hydroxymethylcytidine: A Second Oxidative Derivative of 5-Methylcytidine in RNA. |
Huber SM, van Delft P, Tanpure A, Miska EA, Balasubramanian S... |
Jan. 8, 2017 |
| Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine. |
Ryu H, Grove TL, Almo SC, Kim J... |
Sept. 28, 2018 |
| LC/MS analysis and deep sequencing reveal the accurate RNA composition in the HIV-1 virion. |
Simonova A, Svojanovska B, Trylcova J, Hubalek M, Moravcik O, Zavrel M, Pavova M, Hodek J, Weber J, Cvacka J, Paces J, Cahova H... |
June 18, 2019 |
| RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia. |
A Beghini,C B Ripamonti,P Peterlongo,G Roversi,R Cairoli,E Morra,L Larizza |
Oct. 1, 2000 |
| Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for acutemyeloid leukemia cell proliferation. |
Pauli C, Liu Y, Rohde C, Cui C, Fijalkowska D, Gerloff D, Walter C, Krijgsveld J, Dugas M, Edemir B, Pabst C, Müller LP, Zhou F, Müller-Tidow C |
June 4, 2020 |
| The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness. |
Daniele Hasler,Rajyalakshmi Meduri,Maciej Bąk,Gerhard Lehmann,Leonhard Heizinger,Xin Wang,Zhi-Tong Li,François M Sement,Astrid Bruckmann,Anne-Catherine Dock-Bregeon,Rainer Merkl,Reinhard Kalb,Eva Grauer,Erdmute Kunstmann,Mihaela Zavolan,Mo-Fang Liu,Utz Fischer,Gunter Meister |
March 1, 2020 |
| FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling. |
Li H, Ren Y, Mao K, Hua F, Yang Y, Wei N, Yue C, Li D, Zhang H |
March 25, 2018 |
| The obesity related gene, FTO, interacts with APOE, and is associated withAlzheimer's disease risk: a prospective cohort study. |
Keller L, Xu W, Wang HX, Winblad B, Fratiglioni L, Graff C |
Jan. 1, 2011 |
| Genetic variants in the Fat and Obesity Associated (FTO) gene and risk ofAlzheimer's disease. |
Reitz C, Tosto G, Mayeux R, Luchsinger JA |
Jan. 1, 2012 |
| Underediting of glutamate receptor GluR-B mRNA in malignant gliomas. |
Maas S, Patt S, Schrey M, Rich A |
Dec. 4, 2001 |
| Aberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for newtherapeutic targets? |
Donnelly CJ, Grima JC, Sattler R |
Jan. 1, 2014 |
| Control of human potassium channel inactivation by editing of a small mRNA hairpin. |
Bhalla T, Rosenthal JJ, Holmgren M, Reenan R |
Oct. 1, 2004 |
| The mA methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network. |
Lu Sheng,Qian Gao,Qiuchan Xiong,Haojie Zhang,Mingqing Wu,Yu Liang,Fengyu Zhu,Yingyin Zhang,Xiuhong Zhang,Quan Yuan, |
Jan. 18, 2019 |
| Dynamic mA mRNA methylation reveals the role of METTL3-mA-CDCP1 signaling axis in chemical carcinogenesis. |
Huan Jin,Biao Que,Yinghui Chao,Haiqing Zhang,Xiaoling Ying,Zhongyang Zhou,Zusen Yuan,Jialin Su,Bin Wu,Wenjuan Zhang,Defeng Qi,Demeng Chen,Wang Min,Shuibin Lin, |
Feb. 22, 2019 |
| A commonly carried allele of the obesity-related FTO gene is associated with reducedbrain volume in the healthy elderly. |
Ho AJ, Stein JL, Hua X, Lee S, Hibar DP, Leow AD, Dinov ID, Toga AW, Saykin AJ, Shen L, Foroud T, Pankratz N, Huentelman MJ, Craig DW, Gerber JD, Allen AN, Corneveaux JJ, Stephan DA, DeCarli CS, DeChairo BM, Potkin SG, Jack CR Jr, Weiner MW, Raji CA, Lopez OL, Becker JT, Carmichael OT, Thompson PM |
May 4, 2010 |
| Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome. |
Debora Fumagalli,David Gacquer,Françoise Rothé,Anne Lefort,Frederick Libert,David Brown,Naima Kheddoumi,Adam Shlien,Tomasz Konopka,Roberto Salgado,Denis Larsimont,Kornelia Polyak,Karen Willard-Gallo,Christine Desmedt,Martine Piccart,Marc Abramowicz,Peter J Campbell,Christos Sotiriou,Vincent Detours |
Oct. 1, 2015 |
| p53 acts as a safeguard of translational control by regulating fibrillarin and rRNAmethylation in cancer. |
Marcel V, Ghayad SE, Belin S, Therizols G, Morel AP, Solano-Gonzàlez E, Vendrell JA, Hacot S, Mertani HC, Albaret MA, Bourdon JC, Jordan L, Thompson A, Tafer Y, Cong R, Bouvet P, Saurin JC, Catez F, Prats AC, Puisieux A, Diaz JJ |
Sept. 9, 2013 |
| HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancervia inhibiting tumor suppressor let-7g. |
Cai X, Wang X, Cao C, Gao Y, Zhang S, Yang Z, Liu Y, Zhang X, Zhang W, Ye L |
Feb. 28, 2018 |
| N-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression. |
Brittany A Law,Olga R Ilkayeva,Kristen R Carraway,Christopher L Holley, |
July 27, 2018 |
| N6-methyladenosine-related Genomic Targets are Altered in Breast Cancer Tissue and Associated with Poor Survival. |
Xin Liu,Zihui Dong,Jianhao Li,Yan Yu,Xiaolong Chen,Fang Ren,Guangying Cui, |
Aug. 29, 2019 |
| N6-methyladenosine METTL3 promotes the breast cancer progression via targetingBcl-2. |
Wang H, Xu B, Shi J |
Jan. 5, 2020 |
| Transfer RNA demethylase ALKBH3 promotes cancer progression via induction oftRNA-derived small RNAs. |
Chen Z, Qi M, Shen B, Luo G, Wu Y, Li J, Lu Z, Zheng Z, Dai Q, Wang H |
March 18, 2019 |
| RNA editing of Filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure |
Jain M, Mann TD, Stulić M, Rao SP, Kirsch A, Pullirsch D, Strobl X, Rath C, Reissig L, Moreth K, Klein-Rodewald T, Bekeredjian R, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Pablik E, Cimatti L, Martin D, Zinnanti J, Graier WF, Sibilia M, Frank S, Levanon EY, Jantsch MF |
Oct. 1, 2018 |
| Genetic associations and regulation of expression indicate an independent role for14q32 snoRNAs in human cardiovascular disease. |
Håkansson KEJ, Goossens EAC, Trompet S, van Ingen E, de Vries MR, van der Kwast RVCT, Ripa RS, Kastrup J, Hohensinner PJ, Kaun C, Wojta J, Böhringer S, Le Cessie S, Jukema JW, Quax PHA, Nossent AY |
Aug. 1, 2019 |
| FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation. |
Zhou-Lan Bai,Di Xia,Zhi-Jun Zhao,Ren Zhao,Yan-Yang Wang, |
Feb. 1, 2018 |
| Reduced mA mRNA methylation is correlated with the progression of human cervical cancer. |
Zenghui Li,Beihua Kong,Chen Song,Jianglin Cong,Jianqing Hou, |
Oct. 24, 2017 |
| A-to-I RNA editing of BLCAP lost the inhibition to STAT3 activation in cervicalcancer. |
Chen W, He W, Cai H, Hu B, Zheng C, Ke X, Xie L, Zheng Z, Wu X, Wang H |
June 13, 2017 |
| mA methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways. |
Yikan Cheng,Shubiao Ye,Jianwei Zhang,Runqing Huang,Peisi Li,Huashan Liu,Qiling Deng,Xianrui Wu,Ping Lan, |
June 4, 2019 |
| METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-DependentPrimary miR-375 Processing. |
Chen X, Xu M, Xu X, Zeng K, Liu X, Sun L, Pan B, He B, Pan Y, Sun H, Xia X, Wang S |
Feb. 5, 2020 |
| Oncogene c-Myc promotes epitranscriptome mA reader YTHDF1 expression in colorectal cancer. |
Masamitsu Konno,Ayumu Asai,Jun Koseki,Koichi Kawamoto,Norikatsu Miyoshi,Hidekazu Takahashi,Naohiro Nishida,Naotsugu Haraguchi,Daisuke Sakai,Toshihiro Kudo,Taishi Hata,Chu Matsuda,Tsunekazu Mizushima,Taroh Satoh,Yuichiro Doki,Masaki Mori, |
Dec. 21, 2017 |
| YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma. |
Chunxing Yang,Runliu Wu,Lihua Huang,Shenlei Song,Wanwan Li,Peichen Yan,Changwei Lin,Daojiang Li, |
May 3, 2019 |
| RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiencyby which HIF-1α mRNA is translated. |
Tanabe A, Tanikawa K, Tsunetomi M, Takai K, Ikeda H, Konno J, Torigoe T, Maeda H, Kutomi G, Okita K, Mori M, Sahara H |
June 28, 2016 |
| RNA editing of apolipoprotein B mRNA. Sequence specificity determined by in vitrocoupled transcription editing. |
Chen SH, Li XX, Liao WS, Wu JH, Chan L |
April 25, 1990 |
| mA mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. |
Mark A Eckert,Bryan T Harada,Song-Mei Liu,Zhike Lu,Kangkang Yu,Samantha M Tienda,Agnieszka Chryplewicz,Allen C Zhu,Ying Yang,Jing-Tao Huang,Shao-Min Chen,Zhi-Gao Xu,Xiao-Hua Leng,Xue-Chen Yu,Jie Cao,Zezhou Zhang,Jianzhao Liu,Ernst Lengyel, |
Aug. 27, 2018 |
| RNA editing of drives early tumor invasion and metastasis in familial esophageal cancer. |
Yan-Ru Qin,Xiao-Yan Ming,Xian-Bo Zuo,Yu-Wen Diao,Li-Yi Zhang,Jiaoyu Ai,Bei-Lei Liu,Tu-Xiong Huang,Ting-Ting Cao,Bin-Bin Tan,Di Xiang,Chui-Mian Zeng,Jing Gong,Qiangfeng Zhang,Sui-Sui Dong,Juan Chen,Haibo Liu,Jian-Lin Wu,Robert Z Qi,Dan Xie,Li-Dong Wang, |
May 22, 2017 |
| Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF inesophageal squamous cell carcinoma. |
Li Y, Li J, Luo M, Zhou C, Shi X, Yang W, Lu Z, Chen Z, Sun N, He J |
Aug. 28, 2018 |
| ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1. |
Shuai Guo,Hai-Yan Piao,Yue Wang,Yue Wu,Xiang-Yu Meng,Dong Yang,Zhi-Chao Zheng, |
July 9, 2019 |
| [Knockdown of YTH N(6)-methyladenosine RNA binding protein 2 (YTHDF2) inhibitsproliferation and promotes apoptosis in MGC-803 gastric cancer cells]. |
Zhang J, Pi J, Liu Y, Yu J, Feng T |
Dec. 1, 2017 |
| m1A Regulated Genes Modulate PI3K/AKT/mTOR and ErbB Pathways in GastrointestinalCancer. |
Zhao Y, Zhao Q, Kaboli PJ, Shen J, Li M, Wu X, Yin J, Zhang H, Wu Y, Lin L, Zhang L, Wan L, Wen Q, Li X, Cho CH, Yi T, Li J, Xiao Z |
Oct. 1, 2019 |
| m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells bySustaining FOXM1 Expression and Cell Proliferation Program. |
Zhang S, Zhao BS, Zhou A, Lin K, Zheng S, Lu Z, Chen Y, Sulman EP, Xie K, Bögler O, Majumder S, He C, Huang S |
April 10, 2017 |
| m(6)A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of GlioblastomaStem Cells. |
Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, Sun G, Lu Z, Huang Y, Yang CG, Riggs AD, He C, Shi Y |
March 14, 2017 |
| N⁶-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for theExpression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling |
Visvanathan A, Patil V, Abdulla S, Hoheisel JD, Somasundaram K |
Feb. 13, 2019 |
| Essential role of METTL3-mediated mA modification in glioma stem-like cells maintenance and radioresistance. |
V Patil,A Arora,A S Hegde,A Arivazhagan,V Santosh, |
Oct. 9, 2017 |
| High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis inHead and Neck Squamous Carcinoma. |
Lu L, Zhu G, Zeng H, Xu Q, Holzmann K |
April 21, 2018 |
| Hypermethylation of 28S ribosomal RNA in β-thalassemia trait carriers. |
Sornjai W, Lithanatudom P, Erales J, Joly P, Francina A, Hacot S, Fucharoen S, Svasti S, Diaz JJ, Mertani HC, Smith DR |
Jan. 1, 2017 |
| Expression profiles and prognostic significance of RNA N6-methyladenosine-related genes in patients with hepatocellular carcinoma: evidence from independent datasets. |
Zi Yin,Baohua Hou,Min Yu,Ruiwan Chen,Haosheng Jin, |
May 1, 2019 |
| RNA mA methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. |
Guoshi Chai,Yingmin Wu,Jiexin Li,Feng Chen,Jianzhao Liu,Guanzheng Luo,Jordi Tauler,Jun Du,Shuibin Lin,Chuan He, |
May 6, 2019 |
| MicroRNA-145 Modulates -Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the -Methyladenosine Binding YTH Domain Family 2 Protein. |
Jiong Li,Guoxing Feng,Shan Gao,Yuan Wang,Shuqin Zhang,Yunxia Liu,Lihong Ye,Yueguo Li, |
Jan. 19, 2017 |
| YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA inhepatocellular carcinoma. |
Zhong L, Liao D, Zhang M, Zeng C, Li X, Zhang R, Ma H, Kang T |
Feb. 1, 2019 |
| Overexpression of YTHDF1 is associated with poor prognosis in patients withhepatocellular carcinoma. |
Zhao X, Chen Y, Mao Q, Jiang X, Jiang W, Chen J, Xu W, Zhong L, Sun X |
Jan. 1, 2018 |
| A novel translational repressor mRNA is edited extensively in livers containingtumors caused by the transgene expression of the apoB mRNA-editing enzyme. |
Yamanaka S, Poksay KS, Arnold KS, Innerarity TL |
Feb. 1, 1997 |
| Variants in PUS7 Cause Intellectual Disability with Speech Delay, Microcephaly,Short Stature, and Aggressive Behavior. |
de Brouwer APM, Abou Jamra R, Körtel N, Soyris C, Polla DL, Safra M, Zisso A, Powell CA, Rebelo-Guiomar P, Dinges N, Morin V, Stock M, Hussain M, Shahzad M, Riazuddin S, Ahmed ZM, Pfundt R, Schwarz F, de Boer L, Reis A, Grozeva D, Raymond FL, Riazuddin S, Koolen DA, Minczuk M, Roignant JY, van Bokhoven H, Schwartz S |
Dec. 6, 2018 |
| Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis. |
Li L, Zang L, Zhang F, Chen J, Shen H, Shu L, Liang F, Feng C, Chen D, Tao H, Xu T, Li Z, Kang Y, Wu H, Tang L, Zhang P, Jin P, Shu Q, Li X |
July 1, 2017 |
| PUS7 mutations impair pseudouridylation in humans and cause intellectual disability and microcephaly. |
Monika Tasak,Sateesh Maddirevula,Ghada M H Abdel-Salam,Inas S M Sayed,Anas M Alazami,Tarfa Al-Sheddi,Eman Alobeid,Eric M Phizicky, |
Feb. 18, 2019 |
| METTL3 and ALKBH5 oppositely regulate mA modification of mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes. |
Xing Feng,Heng Zhang,Yunmei Luo,Juan Huang,Meihua Lin,Junfei Jin,Xue Ding,Shujing Wu,He Huang,Tian Yu,Mukun Zhang,Haiou Hong,Shihua Yao,Yongxiang Zhao, |
March 17, 2019 |
| Genetic alterations of mA regulators predict poorer survival in acute myeloid leukemia. |
Amy D Marshall,John E J Rasko, |
Feb. 2, 2017 |
| The N-methyladenosine (mA)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. |
Brian F Pickering,Yuanming Cheng,Sara Zaccara,Diu Nguyen,Gerard Minuesa,Timothy Chou,Arthur Chow,Yogesh Saletore,Matthew MacKay,Jessica Schulman,Christopher Famulare,Minal Patel,Virginia M Klimek,Francine E Garrett-Bakelman,Ari Melnick,Martin Carroll,Christopher E Mason,Samie R Jaffrey, |
Sept. 18, 2017 |
| FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNADemethylase. |
Li Z, Weng H, Su R, Weng X, Zuo Z, Li C, Huang H, Nachtergaele S, Dong L, Hu C, Qin X, Tang L, Wang Y, Hong GM, Huang H, Wang X, Chen P, Gurbuxani S, Arnovitz S, Li Y, Li S, Strong J, Neilly MB, Larson RA, Jiang X, Zhang P, Jin J, He C, Chen J |
Jan. 9, 2017 |
| Targeting the RNA m(6)A Reader YTHDF2 Selectively Compromises Cancer Stem Cells inAcute Myeloid Leukemia. |
Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H, Wotherspoon DA, Sepulveda C, Vukovic M, Allen L, Sarapuu A, Tavosanis A, Guitart AV, Villacreces A, Much C, Choe J, Azar A, van de Lagemaat LN, Vernimmen D, Nehme A, Mazurier F, Somervaille TCP, Gregory RI, O'Carroll D, Kranc KR |
July 3, 2019 |
| Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. |
Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, Ni T, Zhang ZS, Zhang T, Li C, Han L, Zhu Z, Lian F, Wei J, Deng Q, Wang Y, Wunderlich M, Gao Z, Pan G, Zhong D, Zhou H, Zhang N, Gan J, Jiang H, Mulloy JC, Qian Z, Chen J, Yang CG |
April 15, 2019 |
| Suppression of mA reader Ythdf2 promotes hematopoietic stem cell expansion. |
Pengxu Qian,Wanqing Shao,Hailing Shi,Xi C He,Madelaine Gogol,Zulin Yu,Yongfu Wang,Meijie Qi,Yunfei Zhu,John M Perry,Kai Zhang,Fang Tao,Kun Zhou,Deqing Hu,Yingli Han,Chongbei Zhao,Richard Alexander,Hanzhang Xu,Shiyuan Chen,Allison Peak,Kathyrn Hall,Michael Peterson,Anoja Perera,Jeffrey S Haug,Tari Parmely,Hua Li,Bin Shen,Julia Zeitlinger,Chuan He, |
July 31, 2018 |
| METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and PromotesLeukemogenesis via mRNA m(6)A Modification. |
Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore LC, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy JC, Yang J, Qian Z, Wei M, He C, Chen J |
Feb. 1, 2018 |
| An association study of the m6A genes with major depressive disorder in Chinese Hanpopulation. |
Du T, Rao S, Wu L, Ye N, Liu Z, Hu H, Xiu J, Shen Y, Xu Q |
Sept. 1, 2015 |
| mA mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. |
Jiangbo Wei,Yan-Hong Cui,Gayoung Park,Palak Shah,Yu Deng,Andrew E Aplin,Zhike Lu,Seungmin Hwang,Chuan He, |
June 25, 2019 |
| RNA m6A methyltransferase METTL3 regulates invasiveness of melanoma cells by matrixmetallopeptidase 2. |
Dahal U, Le K, Gupta M |
Aug. 1, 2019 |
| Missense mutation in pseudouridine synthase 1 (PUS1) causes mitochondrial myopathyand sideroblastic anemia (MLASA). |
Bykhovskaya Y, Casas K, Mengesha E, Inbal A, Fischel-Ghodsian N |
June 1, 2004 |
| RNA modification landscape of the human mitochondrial tRNA regulates protein synthesis. |
Molly E Evans,Wesley C Clark,Paula Marttinen,Eric A Shoubridge,Anu Suomalainen,Anna Wredenberg,Anna Wedell,Tao Pan, |
Sept. 27, 2018 |
| Pseudouridine Modification Inhibits Muscleblind-like 1 (MBNL1) Binding to CCUG Repeats and Minimally Structured RNA through Reduced RNA Flexibility. |
Melissa N Hinman,Jeremy Copperman,Kausiki Datta,Marina Guenza, |
Jan. 27, 2017 |
| C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both thetype II transcript and apobec-1, the catalytic subunit of the apolipoprotein BmRNA-editing enzyme. |
Mukhopadhyay D, Anant S, Lee RM, Kennedy S, Viskochil D, Davidson NO |
Jan. 1, 2002 |
| The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. |
Lin S, Choe J, Du P, Triboulet R, Gregory RI |
May 5, 2016 |
| MiR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA. |
Du M, Zhang Y, Mao Y, Mou J, Zhao J, Xue Q, Wang D, Huang J, Gao S, Gao Y |
Jan. 22, 2017 |
| mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. |
Shuibin Lin,Wencai Zhang,Qi Liu,Longfei Wang,Julia Ramirez-Moya,Peng Du,Wantae Kim,Shaojun Tang,Piotr Sliz,Pilar Santisteban,Rani E George,William G Richards,Kwok-Kin Wong,Nicolas Locker,Frank J Slack, |
Sept. 19, 2018 |
| The m6A demethylase FTO promotes the growth of lung cancer cells by regulating them6A level of USP7 mRNA. |
Li J, Han Y, Zhang H, Qian Z, Jia W, Gao Y, Zheng H, Li B |
May 7, 2019 |
| m(6)A demethylase FTO facilitates tumor progression in lung squamous cell carcinomaby regulating MZF1 expression. |
Liu J, Ren D, Du Z, Wang H, Zhang H, Jin Y |
Aug. 25, 2018 |
| YTH domain family 2 promotes lung cancer cell growth by facilitating6-phosphogluconate dehydrogenase mRNA translation. |
Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S, Shan C |
July 10, 2020 |
| ALKBH5-m(6)A-FOXM1 signaling axis promotes proliferation and invasion of lungadenocarcinoma cells under intermittent hypoxia. |
Chao Y, Shang J, Ji W |
Jan. 8, 2020 |
| N(6)-methyladenosine ALKBH5 promotes non-small cell lung cancer progress byregulating TIMP3 stability. |
Zhu Z, Qian Q, Zhao X, Ma L, Chen P |
March 20, 2020 |
| Genome-wide association scan shows genetic variants in the FTO gene are associatedwith obesity-related traits. |
Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, Najjar S, Nagaraja R, Orrú M, Usala G, Dei M, Lai S, Maschio A, Busonero F, Mulas A, Ehret GB, Fink AA, Weder AB, Cooper RS, Galan P, Chakravarti A, Schlessinger D, Cao A, Lakatta E, Abecasis GR |
July 1, 2007 |
| Mettl3-mediated mA RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis. |
Liang Xie,Mengyuan Wang,Qiuchan Xiong,Yuchen Guo,Yu Liang,Jing Li,Rui Sheng,Peng Deng,Yuan Wang,Rixin Zheng,Yizhou Jiang,Ling Ye,Qianming Chen,Xuedong Zhou,Shuibin Lin, |
Nov. 14, 2018 |
| The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating them6A level of LEF1. |
Miao W, Chen J, Jia L, Ma J, Song D |
Aug. 27, 2019 |
| Human ALKBH3-induced m(1)A demethylation increases the CSF-1 mRNA stability inbreast and ovarian cancer cells. |
Woo HH, Chambers SK |
Jan. 1, 2019 |
| YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells. |
Yaocheng Sun,Xiao Xu,Dawei Wang,Junbo He,Hailang Zhou,Ying Lu,Jian Zeng,Fengyi Du,Aihua Gong, |
Nov. 14, 2017 |
| Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death. |
Chunyu Yu,Minjun Guo,Xiaotong Zheng,Sakhawat Ali,Hua Huang,Lihua Zhang,Shensen Wang,Yinghui Huang,Shuyan Qie, |
March 14, 2019 |
| Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy. |
Wettengel J, Reautschnig P, Geisler S, Kahle PJ, Stafforst T |
March 17, 2017 |
| The M6A methyltransferase METTL3: acting as a tumor suppressor in renal cell carcinoma. |
Jingyuan Tang,Wen Huang,Feng Wang,Pu Li,Chao Qin,Zhiqiang Qin,Qing Zou,Jifu Wei,Lixin Hua,Haiwei Yang, |
Oct. 10, 2017 |
| Early-onset epilepsy and postnatal lethality associated with an editing-deficientGluR-B allele in mice. |
Brusa R, Zimmermann F, Koh DS, Feldmeyer D, Gass P, Seeburg PH, Sprengel R |
Dec. 8, 1995 |
| A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy. |
Benjamin Förstera,Aline Winkelmann,Pina Knauff,Erich E Wanker,Xintian A You,Marcus Semtner,Florian Hetsch, |
Jan. 11, 2018 |
| The Treacher Collins syndrome (TCOF1) gene product is involved in pre-rRNAmethylation. |
Gonzales B, Henning D, So RB, Dixon J, Dixon MJ, Valdez BC |
July 15, 2005 |
| A common variant in the FTO gene is associated with body mass index and predisposesto childhood and adult obesity. |
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI |
May 11, 2007 |
| mA mRNA Methylation Regulates Human β-Cell Biology in Physiological States and in Type 2 Diabetes. |
Zijie Zhang,Sevim Kahraman,Natalie K Brown,Mengjie Chen,Jiang Hu,Manoj K Gupta,Chuan He, |
July 29, 2019 |
| Global analysis of A-to-I RNA editing reveals association with common disease variants. |
Raili Ermel,Katyayani Sukhavasi,Rajeev Jain,Anamika Jain,Christer Betsholtz,Chiara Giannarelli,Jason C Kovacic,Arno Ruusalepp,Josefin Skogsberg,Ke Hao,Eric E Schadt, |
March 6, 2018 |
| 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs |
Chen X, Li A, Sun BF, Yang Y, Han YN, Yuan X, Chen RX, Wei WS, Liu Y, Gao CC, Chen YS, Zhang M, Ma XD, Liu ZW, Luo JH, Lyu C, Wang HL, Ma J, Zhao YL, Zhou FJ, Huang Y, Xie D, Yang YG. |
Aug. 1, 2019 |
| Cap-specific terminal -methylation of RNA by an RNA polymerase II-associated methyltransferase. |
Shinichiro Akichika,Seiichi Hirano,Yuichi Shichino,Takeo Suzuki,Hiroshi Nishimasu,Ryuichiro Ishitani,Ai Sugita,Yutaka Hirose,Shintaro Iwasaki,Osamu Nureki,Tsutomu Suzuki |
Jan. 1, 2019 |
| Identification of the mAm Methyltransferase PCIF1 Reveals the Location and Functions of mAm in the Transcriptome. |
Konstantinos Boulias,Diana Toczydłowska-Socha,Ben R Hawley,Noa Liberman,Ken Takashima,Sara Zaccara,Théo Guez,Jean-Jacques Vasseur,Françoise Debart,L Aravind,Samie R Jaffrey,Eric Lieberman Greer |
Aug. 1, 2019 |
| PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression. |
Erdem Sendinc,David Valle-Garcia,Abhinav Dhall,Hao Chen,Telmo Henriques,Jose Navarrete-Perea,Wanqiang Sheng,Steven P Gygi,Karen Adelman,Yang Shi |
Aug. 1, 2019 |
| The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. |
Nhan van Tran,Felix G M Ernst,Ben R Hawley,Christiane Zorbas,Nathalie Ulryck,Philipp Hackert,Katherine E Bohnsack,Markus T Bohnsack,Samie R Jaffrey,Marc Graille,Denis L J Lafontaine |
Sept. 1, 2019 |
| The rRNA mA methyltransferase METTL5 is involved in pluripotency and developmental programs. |
Valentina V Ignatova,Paul Stolz,Steffen Kaiser,Tobias H Gustafsson,Palma Rico Lastres,Adrián Sanz-Moreno,Yi-Li Cho,Oana V Amarie,Antonio Aguilar-Pimentel,Tanja Klein-Rodewald,Julia Calzada-Wack,Lore Becker,Susan Marschall,Markus Kraiger,Lillian Garrett,Claudia Seisenberger,Sabine M Hölter,Kayla Borland,Erik Van De Logt,Pascal W T C Jansen,Marijke P Baltissen,Magdalena Valenta,Michiel Vermeulen,Wolfgang Wurst,Valerie Gailus-Durner,Helmut Fuchs,Martin Hrabe de Angelis,Oliver J Rando,Stefanie M Kellner,Sebastian Bultmann,Robert Schneider |
May 1, 2020 |
| NMethyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. |
Honghui Ma,Xiaoyun Wang,Jiabin Cai,Qing Dai,S Kundhavai Natchiar,Ruitu Lv,Kai Chen,Zhike Lu,Hao Chen,Yujiang Geno Shi,Fei Lan,Jia Fan,Bruno P Klaholz,Tao Pan,Yang Shi,Chuan He |
Jan. 1, 2019 |
| The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. |
Rita Pinto,Cathrine B Vågbø,Magnus E Jakobsson,Yeji Kim,Marijke P Baltissen,Marie-Françoise O'Donohue,Ulises H Guzmán,Jędrzej M Małecki,Jie Wu,Finn Kirpekar,Jesper V Olsen,Pierre-Emmanuel Gleizes,Michiel Vermeulen,Sebastian A Leidel,Geir Slupphaug,Pål Ø Falnes |
Jan. 1, 2020 |
| Structure and regulation of ZCCHC4 in mA-methylation of 28S rRNA. |
Wendan Ren,Jiuwei Lu,Mengjiang Huang,Linfeng Gao,Dongxu Li,Gang Greg Wang,Jikui Song |
Nov. 1, 2019 |
| N-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA. |
Ziyang Hao,Tong Wu,Xiaolong Cui,Pingping Zhu,Caiping Tan,Xiaoyang Dou,Kai-Wen Hsu,Yueh-Te Lin,Pei-Hua Peng,Li-Sheng Zhang,Yawei Gao,Lulu Hu,Hui-Lung Sun,Allen Zhu,Jianzhao Liu,Kou-Juey Wu,Chuan He |
May 1, 2020 |
| Division of labour: tRNA methylation by the NSun2 tRNA methyltransferases Trm4a and Trm4b in fission yeast. |
Martin Müller,Anke Samel-Pommerencke,Carine Legrand,Francesca Tuorto,Frank Lyko,Ann E Ehrenhofer-Murray |
March 1, 2019 |
| Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. |
Maria Becker,Sara Müller,Wolfgang Nellen,Tomasz P Jurkowski,Albert Jeltsch,Ann E Ehrenhofer-Murray |
Dec. 1, 2012 |
| Chloroplast development at low temperatures requires a homolog of DIM1, a yeast gene encoding the 18S rRNA dimethylase. |
J G Tokuhisa,P Vijayan,K A Feldmann,J A Browse |
May 1, 1998 |
| RmtC introduces G1405 methylation in 16S rRNA and confers high-level aminoglycoside resistance on Gram-positive microorganisms. |
Jun-Ichi Wachino,Keigo Shibayama,Kouji Kimura,Kunikazu Yamane,Satowa Suzuki,Yoshichika Arakawa |
Oct. 1, 2010 |
| Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition. |
Meisam Nosrati,Debayan Dey,Atousa Mehrani,Sarah E Strassler,Natalia Zelinskaya,Eric D Hoffer,Scott M Stagg,Christine M Dunham,Graeme L Conn |
Nov. 1, 2019 |
| Crystal structure of ErmE - 23S rRNA methyltransferase in macrolide resistance. |
Alena Stsiapanava,Maria Selmer |
Oct. 1, 2019 |
| ErmE methyltransferase recognizes features of the primary and secondary structure in a motif within domain V of 23 S rRNA. |
I D Villsen,B Vester,S Douthwaite |
Feb. 1, 1999 |
| Domain V of 23S rRNA contains all the structural elements necessary for recognition by the ErmE methyltransferase. |
B Vester,S Douthwaite |
Nov. 1, 1994 |
| The conformation of 23S rRNA nucleotide A2058 determines its recognition by the ErmE methyltransferase. |
B Vester,L H Hansen,S Douthwaite |
June 1, 1995 |
| FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA. |
Jean-Michel Carter,Warren Emmett,Igor Rdl Mozos,Annika Kotter,Mark Helm,Jernej Ule,Shobbir Hussain |
Nov. 1, 2019 |
| mU54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs. |
Marisa Pereira,Diana R Ribeiro,Miguel M Pinheiro,Margarida Ferreira,Stefanie Kellner,Ana R Soares |
March 1, 2021 |
| TRMT2B is responsible for both tRNA and rRNA mU-methylation in human mitochondria. |
Christopher A Powell,Michal Minczuk |
April 1, 2020 |
| Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for mU formation in both tRNA and rRNA. |
Ivan Laptev,Ekaterina Shvetsova,Sergey Levitskii,Marina Serebryakova,Maria Rubtsova,Alexey Bogdanov,Piotr Kamenski,Petr Sergiev,Olga Dontsova |
April 1, 2020 |
| Expression and analysis of the SAM-dependent RNA methyltransferase Rsm22 from Saccharomyces cerevisiae. |
Jahangir Alam,Farah Tazkera Rahman,Shiv K Sah-Teli,Rajaram Venkatesan,M Kristian Koski,Kaija J Autio,J Kalervo Hiltunen,Alexander J Kastaniotis |
June 1, 2021 |
| The critical function of the plastid rRNA methyltransferase, CMAL, in ribosome biogenesis and plant development. |
Meijuan Zou,Ying Mu,Xin Chai,Min Ouyang,Long-Jiang Yu,Lixin Zhang,Jörg Meurer,Wei Chi |
April 1, 2020 |
| METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis. |
Lindsey Van Haute,Alan G Hendrick,Aaron R D'Souza,Christopher A Powell,Pedro Rebelo-Guiomar,Michael E Harbour,Shujing Ding,Ian M Fearnley,Byron Andrews,Michal Minczuk |
Nov. 1, 2019 |
| The human mitochondrial 12S rRNA mC methyltransferase METTL15 is required for mitochondrial function. |
Hao Chen,Zhennan Shi,Jiaojiao Guo,Kao-Jung Chang,Qianqian Chen,Cong-Hui Yao,Marcia C Haigis,Yang Shi |
June 1, 2020 |
| METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue. |
Ivan Laptev,Ekaterina Shvetsova,Sergey Levitskii,Marina Serebryakova,Maria Rubtsova,Victor Zgoda,Alexey Bogdanov,Piotr Kamenski,Petr Sergiev,Olga Dontsova |
Aug. 1, 2020 |
| A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. |
Jason D Arroyo,Alexis A Jourdain,Sarah E Calvo,Carmine A Ballarano,John G Doench,David E Root,Vamsi K Mootha |
Dec. 1, 2016 |
| Mammalian nuclear TRUB1, mitochondrial TRUB2, and cytoplasmic PUS10 produce conserved pseudouridine 55 in different sets of tRNA. |
Shaoni Mukhopadhyay,Manisha Deogharia,Ramesh Gupta |
Jan. 1, 2021 |
| TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code. |
Modi Safra,Ronit Nir,Daneyal Farouq,Ilya Vainberg Slutskin,Schraga Schwartz |
March 1, 2017 |
| Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6. |
Xue-Ling Mao,Zi-Han Li,Meng-Han Huang,Jin-Tao Wang,Jing-Bo Zhou,Qing-Run Li,Hong Xu,Xi-Jin Wang,Xiao-Long Zhou |
Aug. 1, 2021 |
| Cytosine-5 RNA methylation links protein synthesis to cell metabolism. |
Nikoletta A Gkatza,Cecilia Castro,Robert F Harvey,Matthias Heiß,Martyna C Popis,Sandra Blanco,Susanne Bornelöv,Abdulrahim A Sajini,Joseph G Gleeson,Julian L Griffin,James A West,Stefanie Kellner,Anne E Willis,Sabine Dietmann,Michaela Frye |
June 1, 2019 |
| The tRNA methyltransferase NSun2 stabilizes p16INK⁴ mRNA by methylating the 3'-untranslated region of p16. |
Xiaotian Zhang,Zhenyun Liu,Jie Yi,Hao Tang,Junyue Xing,Minqwei Yu,Tanjun Tong,Yongfeng Shang,Myriam Gorospe,Wengong Wang |
March 1, 2012 |
| Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation. |
Abdulrahim A Sajini,Nila Roy Choudhury,Rebecca E Wagner,Susanne Bornelöv,Tommaso Selmi,Christos Spanos,Sabine Dietmann,Juri Rappsilber,Gracjan Michlewski,Michaela Frye |
June 1, 2019 |
| Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation. |
Jinghui Song,Yuan Zhuang,Chenxu Zhu,Haowei Meng,Bo Lu,Bingteng Xie,Jinying Peng,Mo Li,Chengqi Yi |
Feb. 1, 2020 |
| The human ortholog of archaeal Pus10 produces pseudouridine 54 in select tRNAs where its recognition sequence contains a modified residue. |
Manisha Deogharia,Shaoni Mukhopadhyay,Archi Joardar,Ramesh Gupta |
March 1, 2019 |
| Functional organization of box C/D RNA-guided RNA methyltransferase. |
Zuxiao Yang,Jiayin Wang,Lin Huang,David M J Lilley,Keqiong Ye |
May 1, 2020 |
| Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. |
Xiaodan Liu,Shengqi Shen,Pengzhi Wu,Fudong Li,Xing Liu,Chongyuan Wang,Qingguo Gong,Jihui Wu,Xuebiao Yao,Huafeng Zhang,Yunyu Shi |
Aug. 1, 2019 |
| Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates. |
Dan Bar-Yaacov,Idan Frumkin,Yuka Yashiro,Takeshi Chujo,Yuma Ishigami,Yonatan Chemla,Amit Blumberg,Orr Schlesinger,Philipp Bieri,Basil Greber,Nenad Ban,Raz Zarivach,Lital Alfonta,Yitzhak Pilpel,Tsutomu Suzuki,Dan Mishmar |
Sept. 1, 2016 |
| Distinct substrate specificities of the human tRNA methyltransferases TRMT10A and TRMT10B. |
Nathan W Howell,Manasses Jora,Benjamin F Jepson,Patrick A Limbach,Jane E Jackman |
Oct. 1, 2019 |
| Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability. |
Y Nagayoshi,T Chujo,S Hirata,H Nakatsuka,C-W Chen,M Takakura,K Miyauchi,Y Ikeuchi,B C Carlyle,R R Kitchen,T Suzuki,F Katsuoka,M Yamamoto,Y Goto,M Tanaka,K Natsume,A C Nairn,T Suzuki,K Tomizawa,F-Y Wei |
March 1, 2021 |
| 1 METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs |
J M Lentini, R Bargabos, C Chen, and D Fu |
Dec. 1, 2021 |
| Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase. |
Konstantin A Ivanov,Volker Thiel,Jessika C Dobbe,Yvonne van der Meer,Eric J Snijder,John Ziebuhr |
July 1, 2004 |
| Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. |
Liming Yan,Ji Ge,Litao Zheng,Ying Zhang,Yan Gao,Tao Wang,Yucen Huang,Yunxiang Yang,Shan Gao,Mingyu Li,Zhenyu Liu,Haofeng Wang,Yingjian Li,Yu Chen,Luke W Guddat,Quan Wang,Zihe Rao,Zhiyong Lou |
Jan. 1, 2021 |
| Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase. |
Souradeep Basu,Tiffany Mak,Rachel Ulferts,Mary Wu,Tom Deegan,Ryo Fujisawa,Kang Wei Tan,Chew Theng Lim,Clovis Basier,Berta Canal,Joseph F Curran,Lucy S Drury,Allison W McClure,Emma L Roberts,Florian Weissmann,Theresa U Zeisner,Rupert Beale,Victoria H Cowling,Michael Howell,Karim Labib,John F X Diffley |
July 1, 2021 |
| Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity. |
Sheng Lin,Hua Chen,Zimin Chen,Fanli Yang,Fei Ye,Yue Zheng,Jing Yang,Xi Lin,Honglu Sun,Lingling Wang,Ao Wen,Haohao Dong,Qingjie Xiao,Dong Deng,Yu Cao,Guangwen Lu |
May 1, 2021 |
| A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex. |
Aliakbar Khalili Yazdi,Fengling Li,Kanchan Devkota,Sumera Perveen,Pegah Ghiabi,Taraneh Hajian,Albina Bolotokova,Masoud Vedadi |
July 1, 2021 |
| Functional characterization of the mammalian mRNA decapping enzyme hDcp2. |
Christopher Piccirillo,Richie Khanna,Megerditch Kiledjian |
Sept. 1, 2003 |
| Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. |
Erwin van Dijk,Nicolas Cougot,Sylke Meyer,Sylvie Babajko,Elmar Wahle,Bertrand Séraphin |
Dec. 1, 2002 |
| Multiple mRNA decapping enzymes in mammalian cells. |
Man-Gen Song,You Li,Megerditch Kiledjian |
Nov. 1, 2010 |
| The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes |
S Kramer |
None |
| Local cerebral glucose consumption during ethanol withdrawal in the rat: effects of single and multiple episodes and previous convulsive seizures. |
L Clemmesen,M Ingvar,R Hemmingsen,T G Bolwig |
June 1, 1988 |
| The crystal structure of the lysyl-tRNA synthetase (LysU) from Escherichia coli. |
S Onesti,A D Miller,P Brick |
Feb. 1, 1995 |
| Stresses that Raise NpA Levels Induce Protective Nucleoside Tetraphosphate Capping of Bacterial RNA. |
Daniel J Luciano,Rose Levenson-Palmer,Joel G Belasco |
Sept. 1, 2019 |
| Extensive 5'-surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast. |
Yaqing Zhang,David Kuster,Tobias Schmidt,Daniel Kirrmaier,Gabriele Nübel,David Ibberson,Vladimir Benes,Hans Hombauer,Michael Knop,Andres Jäschke |
Nov. 1, 2020 |
| "NAD-capQ" detection and quantitation of NAD caps. |
Ewa Grudzien-Nogalska,Jeremy G Bird,Bryce E Nickels,Megerditch Kiledjian |
Oct. 1, 2018 |
| Identification of a quality-control mechanism for mRNA 5'-end capping. |
Xinfu Jiao,Song Xiang,Chanseok Oh,Charles E Martin,Liang Tong,Megerditch Kiledjian |
Sept. 1, 2010 |
| The NADH diphosphatase encoded by the Saccharomyces cerevisiae NPY1 nudix hydrolase gene is located in peroxisomes. |
S R AbdelRaheim,J L Cartwright,L Gasmi,A G McLennan |
April 1, 2001 |
| 5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding. |
Xinfu Jiao,Selom K Doamekpor,Jeremy G Bird,Bryce E Nickels,Liang Tong,Ronald P Hart,Megerditch Kiledjian |
March 1, 2017 |
| Structural and mechanistic basis of mammalian Nudt12 RNA deNADding. |
Ewa Grudzien-Nogalska,Yixuan Wu,Xinfu Jiao,Huijuan Cui,Maria K Mateyak,Ronald P Hart,Liang Tong,Megerditch Kiledjian |
June 1, 2019 |
| 2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO |
F Picard-Jean, C Brand, M Tremblay-Létourneau, A Allaire, M C Beaudoin, S Boudreault, C Duval, J Rainville-Sirois , F Robert, J Pelletier, B J Geiss, M Bisaillon |
March 1, 2018 |
| Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin. |
Petra Krafcikova,Jan Silhan,Radim Nencka,Evzen Boura |
July 1, 2020 |
| High-resolution structures of the SARS-CoV-2 2'--methyltransferase reveal strategies for structure-based inhibitor design. |
Monica Rosas-Lemus,George Minasov,Ludmilla Shuvalova,Nicole L Inniss,Olga Kiryukhina,Joseph Brunzelle,Karla J F Satchell |
Sept. 1, 2020 |
| Oncogene c-Myc promotes epitranscriptome mA reader YTHDF1 expression in colorectal cancer. |
Yujiro Nishizawa,Masamitsu Konno,Ayumu Asai,Jun Koseki,Koichi Kawamoto,Norikatsu Miyoshi,Hidekazu Takahashi,Naohiro Nishida,Naotsugu Haraguchi,Daisuke Sakai,Toshihiro Kudo,Taishi Hata,Chu Matsuda,Tsunekazu Mizushima,Taroh Satoh,Yuichiro Doki,Masaki Mori,Hideshi Ishii |
Jan. 1, 2018 |
| YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma |
Y Bai, C Yang, R Wu, L Huang, S Song, W Li, P Yan, C Lin, D Li, Y Zhang |
May 3, 2019 |
| METTL3 Promotes the Proliferation and Mobility of Gastric Cancer Cells |
S Lin , J Liu, W Jiang, P Wang, C Sun, X Wang, Y Chen, H Wang |
March 1, 2019 |
| Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer. |
Tong Liu,Sheng Yang,Jing Sui,Si-Yi Xu,Yan-Ping Cheng,Bo Shen,Yan Zhang,Xiao-Mei Zhang,Li-Hong Yin,Yue-Pu Pu,Ge-Yu Liang |
Jan. 1, 2020 |
| FTO expression is associated with the occurrence of gastric cancer and prognosis. |
Dong Xu,Weiwei Shao,Yasu Jiang,Xi Wang,Ying Liu,Xianchen Liu |
Oct. 1, 2017 |
| Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer. |
Yue Li,Danyang Zheng,Fang Wang,Yuxia Xu,Hongyang Yu,Huizhong Zhang |
June 1, 2019 |
| N⁶-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling. |
Abhirami Visvanathan,Vikas Patil,Shibla Abdulla,Jörg D Hoheisel,Kumaravel Somasundaram |
Feb. 1, 2019 |
| Essential role of METTL3-mediated mA modification in glioma stem-like cells maintenance and radioresistance. |
A Visvanathan,V Patil,A Arora,A S Hegde,A Arivazhagan,V Santosh,K Somasundaram |
Jan. 1, 2018 |
| Expression and roles of Wilms' tumor 1-associating protein in glioblastoma. |
Du-Il Jin,Sang Weon Lee,Myoung-Eun Han,Hyun-Jung Kim,Seon-Ae Seo,Gi-Yeong Hur,Shin Jung,Bong-Seon Kim,Sae-Ock Oh |
Dec. 1, 2012 |
| WTAP Expression Predicts Poor Prognosis in Malignant Glioma Patients. |
Zhuo Xi,Yixue Xue,Jian Zheng,Xiaobai Liu,Jun Ma,Yunhui Liu |
Oct. 1, 2016 |
| Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma |
X Zhao, Y Chen, Q Mao, X Jiang, W Jiang, J Chen , W Xu, L Zhong, X Sun |
Jan. 1, 2018 |
| Expression profiles and prognostic significance of RNA N6-methyladenosine-related genes in patients with hepatocellular carcinoma: evidence from independent datasets |
Y Zhou, Z Yin, B Hou, M Yu, R Chen, H Jin, Z Jian |
March 1, 2019 |
| The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression. |
Z Samaan,S S Anand,S Anand,X Zhang,D Desai,M Rivera,G Pare,L Thabane,C Xie,H Gerstein,J C Engert,I Craig,S Cohen-Woods,V Mohan,R Diaz,X Wang,L Liu,T Corre,M Preisig,Z Kutalik,S Bergmann,P Vollenweider,G Waeber,S Yusuf,D Meyre |
Dec. 1, 2013 |
| Overview of distinct 5-methylcytosine profiles of messenger RNA in human hepatocellular carcinoma and paired adjacent non-tumor tissues. |
Qiyao Zhang,Qingyuan Zheng,Xiao Yu,Yuting He,Wenzhi Guo |
June 1, 2020 |
| NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation. |
Yuanbo Hu,Chenbin Chen,Xinya Tong,Sian Chen,Xianjing Hu,Bujian Pan,Xiangwei Sun,Zhiyuan Chen,Xinyu Shi,Yingying Hu,Xian Shen,Xiangyang Xue,Mingdong Lu |
Sept. 1, 2021 |
| The RNA methyltransferase NSUN6 suppresses pancreatic cancer development by regulating cell proliferation. |
Ruimeng Yang,Xing Liang,Hui Wang,Miaomiao Guo,Hui Shen,Yongheng Shi,Qiang Liu,Yongwei Sun,Linhua Yang,Ming Zhan |
Jan. 1, 2021 |
| N1-methyladenosine profiling of long non-coding RNA in colorectal cancer. |
Liuhong Shi,Wenwen Chen,Zizhen Zhang,Jingyu Chen,Meng Xue |
July 1, 2021 |
| Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease |
Khen Khermesh , Anna Maria D'Erchia , Michal Barak , Anita Annese , Chaim Wachtel , Erez Y Levanon , Ernesto Picardi , Eli Eisenberg |
Feb. 1, 2016 |
| Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing |
U Kim , Y Wang, T Sanford, Y Zeng, K Nishikura |
Nov. 1, 1994 |
| Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis |
H Takuma , S Kwak, T Yoshizawa, I Kanazawa |
None |
| Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons |
Takuto Hideyama, Takenari Yamashita, Hitoshi Aizawa, Shoji Tsuji, Akiyoshi Kakita, Hitoshi Takahashi, Shin Kwak |
March 1, 2012 |
| Altered Editing of Serotonin 2C Receptor Pre-mRNA in the Prefrontal Cortex of Depressed Suicide Victims |
Ilona Gurevich, Hadassah Tamir, Victoria Arango, Andrew J. Dwork, J. John Mann, Claudia Schmauss |
None |
| Mutations of the RNA-Specific Adenosine Deaminase Gene (DSRAD) Are Involved in Dyschromatosis Symmetrica Hereditaria |
Yoshinori Miyamura,Tamio Suzuki, Michihiro Kono Katsuhiko, Inagaki ShiroIto, Noriyuki Suzuki, Yasushi Tomita |
Sept. 1, 2003 |
| Altered adenosine-to-inosine RNA editing in human cancer |
Nurit Paz, Erez Y Levanon, Ninette Amariglio, Amy B Heimberger, Zvi Ram, Shlomi Constantini, Zohar S Barbash, Konstantin Adamsky, Michal Safran, Avi Hirschberg, Meir Krupsky, Issachar Ben-Dov, Simona Cazacu, Tom Mikkelsen, Chaya Brodie, Eli Eisenberg, Gideon Rechavi |
Oct. 1, 2007 |
| AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders |
Vincenzo Salpietro et al. |
July 12, 2019 |
| RNA editing of the 5-HT2C receptor is reduced in schizophrenia |
M S Sodhi , P W Burnet, A J Makoff, R W Kerwin, P J Harrison |
July 1, 2007 |
| Region-specific alterations of A-to-I RNA editing of serotonin 2c receptor in the cortex of suicides with major depression |
D Weissmann, S van der Laan, M D Underwood, N Salvetat, L Cavarec, L Vincent, F Molina, J J Mann, V Arango & J F Pujol |
None |
| Increased adenosine-to-inosine RNA editing in rheumatoid arthritis |
Nikolaos I Vlachogiannis , Aikaterini Gatsiou , Domenico Alessandro Silvestris , Kimon Stamatelopoulos , Maria G Tektonidou , Angela Gallo , Petros P Sfikakis , Konstantinos Stellos |
None |
| Human BLCAP transcript: new editing events in normal andcancerous tissues |
Federica Galeano, Anne Leroy, Claudia Rossetti, Irina Gromova, Philippe Gautier, Liam P. Keegan,Luca Massimi,Concezio Di Rocco,Mary A. O'Connell,Angela Gallo |
April 10, 2010 |
| Altered editing in cyclic nucleotide phosphodiesterase 8A1 gene transcripts of systemic lupus erythematosus T lymphocytes |
Robert J Orlowski, Kenneth S O'Rourke, Irene Olorenshaw, Gregory A Hawkins, Stefan Maas, Dama Laxminarayana |
Nov. 1, 2008 |
| RNA editing (R/G site) and flip–flop splicing of the AMPA receptorsubunit GluR2 in nervous tissue of epilepsy patients |
W Vollmar, J Gloger, E Berger, G Kortenbruck, R Köhling, E-J Speckmann, U Musshoff |
March 1, 2004 |
| The Neurofibromatosis Type I Messenger RNA Undergoes Base-Modification RNA Editing |
G R Skuse, A J Cappione, M Sowden, L J Metheny, H C Smith |
Feb. 1, 1996 |
| The ADAR protein family |
Yiannis A Savva, Leila E Rieder, Robert A Reenan |
Dec. 28, 2012 |
| Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B. |
Shi, K., Demir, O., Carpenter, M.A., Wagner, J., Kurahashi, K., Harris, R.S., Amaro, R.E., Aihara, H. |
None |
| Crystal structure of Bacillus subtilis TrmB, the tRNA (m7G46) methyltransferase. |
Zegers, I., Gigot, D., van Vliet, F., Tricot, C., Aymerich, S., Bujnicki, J.M., Kosinski, J., Droogmans, L. |
None |
| Crystal Structure of Glutamyl-Queuosine Trnaasp Synthetase Complexed with L-Glutamate: Structural Elements Mediating tRNA-Independent Activation of Glutamate and Glutamylation of Trnaasp Anticodon. |
Blaise, M., Olieric, V., Sauter, C., Lorber, B., Roy, B., Karmakar, S., Banerjee, R., Becker, H.D., Kern, D. |
None |
| Structural organization of box C/D RNA-guided RNA methyltransferase. |
Ye, K., Jia, R., Lin, J., Ju, M., Peng, J., Xu, A., Zhang, L. |
None |
| Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer. |
Bedi, R.K., Huang, D., Eberle, S.A., Wiedmer, L., Sledz, P., Caflisch, A. |
None |
| Mechanism of 5' splice site transfer for human spliceosome activation. |
Charenton, C., Wilkinson, M.E., Nagai, K. |
None |
| Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2. |
Bou-Nader, C., Barraud, P., Pecqueur, L., Perez, J., Velours, C., Shepard, W., Fontecave, M., Tisne, C., Hamdane, D. |
None |
| Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs. |
Sharma, S., Grudzien-Nogalska, E., Hamilton, K., Jiao, X., Yang, J., Tong, L., Kiledjian, M. |
None |
| The Structure of Escherichia coli TcdA (Also Known As CsdL) Reveals a Novel Topology and Provides Insight into the tRNA Binding Surface Required for N(6)-Threonylcarbamoyladenosine Dehydratase Activity. |
Kim, S., Lee, H., Park, S. |
None |
| Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA |
Kuratani, M., Bessho, Y., Nishimoto, M., Grosjean, H., Yokoyama, S. |
None |
| Domain Organization and Crystal Structure of the Catalytic Domain of E.coli RluF, a Pseudouridine Synthase that Acts on 23S rRNA |
Sunita, S., Zhenxing, H., Swaathi, J., Cygler, M., Matte, A., Sivaraman, J. |
None |
| Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II-associated methyltransferase. |
Akichika, S., Hirano, S., Shichino, Y., Suzuki, T., Nishimasu, H., Ishitani, R., Sugita, A., Hirose, Y., Iwasaki, S., Nureki, O., Suzuki, T. |
None |
| The structure of the TrmE GTP-binding protein and its implications for tRNA modification |
Scrima, A., Vetter, I.R., Armengod, M.E., Wittinghofer, A. |
None |
| Analysis of pre-mRNA and pre-rRNA processing factor Snu13p structure and mutants. |
Dobbyn, H.C., McEwan, P.A., Krause, A., Novak-Frazer, L., Bella, J., O'Keefe, R.T. |
None |
| Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. |
Finer-Moore, J., Czudnochowski, N., O'Connell, J.D., Wang, A.L., Stroud, R.M. |
None |
| Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. |
Xu, C., Liu, K., Tempel, W., Demetriades, M., Aik, W., Schofield, C.J., Min, J. |
None |
| Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. |
Liu, S., Ghalei, H., Luhrmann, R., Wahl, M.C. |
None |
| The structure of the yrdC gene product from Escherichia coli reveals a new fold and suggests a role in RNA binding. |
Teplova, M., Tereshko, V., Sanishvili, R., Joachimiak, A., Bushueva, T., Anderson, W.F., Egli, M. |
None |
| Structure and function of archaeal box C/D sRNP core proteins. |
Aittaleb, M., Rashid, R., Chen, Q., Palmer, J.R., Daniels, C.J., Li, H. |
None |
| Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2 |
Umitsu, M., Nishimasu, H., Noma, A., Suzuki, T., Ishitani, R., Nureki, O. |
None |
| Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition. |
Nosrati, M., Dey, D., Mehrani, A., Strassler, S.E., Zelinskaya, N., Hoffer, E.D., Stagg, S.M., Dunham, C.M., Conn, G.L. |
None |
| Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate |
Xie, W., Liu, X., Huang, R.H. |
None |
| Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex. |
Zhang, W., Collinet, B., Graille, M., Daugeron, M.C., Lazar, N., Libri, D., Durand, D., van Tilbeurgh, H. |
None |
| The Yeast Ribosome Synthesis Factor Emg1 is a Novel Member of the Superfamily of Alpha/Beta Knot Fold Methyltransferases. |
Leulliot, N., Bohnsack, M.T., Graille, M., Tollervey, D., Van Tilbeurgh, H. |
None |
| Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG |
Gregory, S.T., Demirci, H., Belardinelli, R., Monshupanee, T., Gualerzi, C., Dahlberg, A.E., Jogl, G. |
None |
| Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG |
Gregory, S.T., Demirci, H., Belardinelli, R., Monshupanee, T., Gualerzi, C., Dahlberg, A.E., Jogl, G. |
None |
| Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase. |
Wang, Q., Wu, J., Wang, H., Gao, Y., Liu, Q., Mu, A., Ji, W., Yan, L., Zhu, Y., Zhu, C., Fang, X., Yang, X., Huang, Y., Gao, H., Liu, F., Ge, J., Sun, Q., Yang, X., Xu, W., Liu, Z., Yang, H., Lou, Z., Jiang, B., Guddat, L.W., Gong, P., Rao, Z. |
None |
| Characterization of Two Homologous 2'-O-Methyltransferases Showing Different Specificities for Their tRNA Substrates. |
Somme, J., Van Laer, B., Roovers, M., Steyaert, J., Versees, W., Droogmans, L. |
None |
| Alternate rRNA secondary structures as regulators of translation |
Feng, S., Li, H., Zhao, J., Pervushin, K., Lowenhaupt, K., Schwartz, T.U., Droge, P. |
None |
| The First Structure of an RNA m5C Methyltransferase, Fmu, Provides Insight into Catalytic Mechanism and Specific Binding of RNA Substrate |
Foster, P.G., Nunes, C.R., Greene, P., Moustakas, D., Stroud, R.M. |
None |
| Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria. |
Macmaster, R., Zelinskaya, N., Savic, M., Rankin, C.R., Conn, G.L. |
None |
| Crystal Structure of the Human tRNA Guanine Transglycosylase Catalytic Subunit QTRT1. |
Johannsson, S., Neumann, P., Ficner, R. |
None |
| The Structure of the Box C/D Enzyme Reveals Regulation of RNA Methylation. |
Lapinaite, A., Simon, B., Skjaerven, L., Rakwalska-Bange, M., Gabel, F., Carlomagno, T. |
None |
| Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping. |
Chen, N., Walsh, M.A., Liu, Y., Parker, R., Song, H. |
None |
| New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1. |
Zong, G., Jork, N., Hostachy, S., Fiedler, D., Jessen, H.J., Shears, S.B., Wang, H. |
None |
| Steroid Receptor RNA Activator (SRA) Modification by the Human Pseudouridine Synthase 1 (hPus1p): RNA Binding, Activity, and Atomic Model |
Huet, T., Miannay, F.-A., Patton, J.R., Thore, S. |
None |
| Structural basis of tRNA agmatinylation essential for AUA codon decoding |
Osawa, T., Kimura, S., Terasaka, N., Inanaga, H., Suzuki, T., Numata, T. |
None |
| Methyltransferase that modifies guanine 966 of the 16 S rRNA: functional identification and tertiary structure. |
Lesnyak, D.V., Osipiuk, J., Skarina, T., Sergiev, P.V., Bogdanov, A.A., Edwards, A., Savchenko, A., Joachimiak, A., Dontsova, O.A. |
None |
| Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase |
Li, S., Duan, J., Li, D., Yang, B., Dong, M., Ye, K. |
None |
| Crystal Structure of the Spliceosomal 15.5Kd Protein Bound to a U4 Snrna Fragment |
Vidovic, I., Nottrott, S., Hartmuth, K., Luhrmann, R., Ficner, R. |
None |
| Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases |
Schmitt, E., Galimand, M., Panvert, M., Courvalin, P., Mechulam, Y. |
None |
| The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism. |
Shaban, N.M., Shi, K., Lauer, K.V., Carpenter, M.A., Richards, C.M., Salamango, D., Wang, J., Lopresti, M.W., Banerjee, S., Levin-Klein, R., Brown, W.L., Aihara, H., Harris, R.S. |
None |
| Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine. |
Demirci, H., Belardinelli, R., Seri, E., Gregory, S.T., Gualerzi, C., Dahlberg, A.E., Jogl, G. |
None |
| Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. |
Shao, Z., Yan, W., Peng, J., Zuo, X., Zou, Y., Li, F., Gong, D., Ma, R., Wu, J., Shi, Y., Zhang, Z., Teng, M., Li, X., Gong, Q. |
None |
| Structural and biochemical insights into 2'-O-methylation at the 3'-terminal nucleotide of RNA by Hen1. |
Mui Chan, C., Zhou, C., Brunzelle, J.S., Huang, R.H. |
None |
| Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA |
Liang, B., Zhou, J., Kahen, E., Terns, R.M., Terns, M.P., Li, H. |
None |
| Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes |
Letoquart, J., Huvelle, E., Wacheul, L., Bourgeois, G., Zorbas, C., Graille, M., Heurgue-Hamard, V., Lafontaine, D.L.J. |
None |
| Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP. |
Sivaraman, J., Sauve, V., Larocque, R., Stura, E.A., Schrag, J.D., Cygler, M., Matte, A. |
None |
| Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases. |
Alian, A., Lee, T.T., Griner, S.L., Stroud, R.M., Finer-Moore, J. |
None |
| Deep Knot Structure for Construction of Active Site and Cofactor Binding Site of tRNA Modification Enzyme |
Nureki, O., Watanabe, K., Fukai, S., Ishii, R., Endo, Y., Hori, H., Yokoyama, S. |
None |
| Binding of adenosine-based ligands to the MjDim1 rRNA methyltransferase: implications for reaction mechanism and drug design. |
O'Farrell, H.C., Musayev, F.N., Scarsdale, J.N., Rife, J.P. |
None |
| Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. |
Yankova, E., Blackaby, W., Albertella, M., Rak, J., De Braekeleer, E., Tsagkogeorga, G., Pilka, E.S., Aspris, D., Leggate, D., Hendrick, A.G., Webster, N.A., Andrews, B., Fosbeary, R., Guest, P., Irigoyen, N., Eleftheriou, M., Gozdecka, M., Dias, J.M.L., Bannister, A.J., Vick, B., Jeremias, I., Vassiliou, G.S., Rausch, O., Tzelepis, K., Kouzarides, T. |
None |
| Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes |
Mosbacher, T.G., Bechthold, A., Schulz, G.E. |
None |
| Crystal structure of a junction between two Z-DNA helices. |
de Rosa, M., de Sanctis, D., Rosario, A.L., Archer, M., Rich, A., Athanasiadis, A., Carrondo, M.A. |
None |
| Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation. |
Xiao, X., Yang, H., Arutiunian, V., Fang, Y., Besse, G., Morimoto, C., Zirkle, B., Chen, X.S. |
None |
| Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification. |
Kim, J., Xiao, H., Koh, J., Wang, Y., Bonanno, J.B., Thomas, K., Babbitt, P.C., Brown, S., Lee, Y.S., Almo, S.C. |
None |
| Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. |
Holden, L.G., Prochnow, C., Chang, Y.P., Bransteitter, R., Chelico, L., Sen, U., Stevens, R.C., Goodman, M.F., Chen, X.S. |
None |
| Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. |
Demirci, H., Larsen, L.H., Hansen, T., Rasmussen, A., Cadambi, A., Gregory, S.T., Kirpekar, F., Jogl, G. |
None |
| Cocrystal structure of a tRNA Psi55 pseudouridine synthase: nucleotide flipping by an RNA-modifying enzyme. |
Hoang, C., Ferre-D'Amare, A.R. |
None |
| Structural basis for methyl transfer by a radical SAM enzyme. |
Boal, A.K., Grove, T.L., McLaughlin, M.I., Yennawar, N.H., Booker, S.J., Rosenzweig, A.C. |
None |
| Insights into molecular plasticity in protein complexes from Trm9-Trm112 tRNA modifying enzyme crystal structure. |
Letoquart, J., van Tran, N., Caroline, V., Aleksandrov, A., Lazar, N., van Tilbeurgh, H., Liger, D., Graille, M. |
None |
| AID Recognizes Structured DNA for Class Switch Recombination. |
Qiao, Q., Wang, L., Meng, F.L., Hwang, J.K., Alt, F.W., Wu, H. |
None |
| Alternative Conformations of the Archaeal Nop56/58-Fibrillarin Complex Imply Flexibility in Box C/D RNPs. |
Oruganti, S., Zhang, Y., Li, H., Robinson, H., Terns, M.P., Terns, R.M., Yang, W., Li, H. |
None |
| Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase. |
Nakanishi, K., Bonnefond, L., Kimura, S., Suzuki, T., Ishitani, R., Nureki, O. |
None |
| An extended dsRBD is required for post-transcriptional modification in human tRNAs. |
Bou-Nader, C., Pecqueur, L., Bregeon, D., Kamah, A., Guerineau, V., Golinelli-Pimpaneau, B., Guimaraes, B.G., Fontecave, M., Hamdane, D. |
None |
| How U38, 39, and 40 of Many tRNAs Become the Targets for Pseudouridylation by TruA. |
Hur, S., Stroud, R.M. |
None |
| Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle. |
Xue, S., Wang, R., Yang, F., Terns, R.M., Terns, M.P., Zhang, X., Maxwell, E.S., Li, H. |
None |
| Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors. |
Kirchdoerfer, R.N., Ward, A.B. |
None |
| Functional Implications for a Prototypical K-Turn Binding Protein from Structural and Dynamical Studies of 15.5K |
Soss, S.E., Flynn, P.F. |
None |
| Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. |
Huang, J., Dong, X., Gong, Z., Qin, L.Y., Yang, S., Zhu, Y.L., Wang, X., Zhang, D., Zou, T., Yin, P., Tang, C. |
None |
| Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases. |
Bou-Nader, C., Bregeon, D., Pecqueur, L., Fontecave, M., Hamdane, D. |
None |
| Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins. |
Thirawatananond, P., McPherson, R.L., Malhi, J., Nathan, S., Lambrecht, M.J., Brichacek, M., Hergenrother, P.J., Leung, A.K.L., Gabelli, S.B. |
None |
| Structure analysis of the conserved methyltransferase domain of human trimethylguanosine synthase TGS1. |
Monecke, T., Dickmanns, A., Strasser, A., Ficner, R. |
None |
| High precision NMR structure of YhhP, a novel Escherichia coli protein implicated in cell division. |
Katoh, E., Hatta, T., Shindo, H., Ishii, Y., Yamada, H., Mizuno, T., Yamazaki, T. |
None |
| Structure of the RNA-dependent RNA polymerase from COVID-19 virus. |
Gao, Y., Yan, L., Huang, Y., Liu, F., Zhao, Y., Cao, L., Wang, T., Sun, Q., Ming, Z., Zhang, L., Ge, J., Zheng, L., Zhang, Y., Wang, H., Zhu, Y., Zhu, C., Hu, T., Hua, T., Zhang, B., Yang, X., Li, J., Yang, H., Liu, Z., Xu, W., Guddat, L.W., Wang, Q., Lou, Z., Rao, Z. |
None |
| Structural Insights into HIV-1 Vif-APOBEC3F Interaction. |
Nakashima, M., Ode, H., Kawamura, T., Kitamura, S., Naganawa, Y., Awazu, H., Tsuzuki, S., Matsuoka, K., Nemoto, M., Hachiya, A., Sugiura, W., Yokomaku, Y., Watanabe, N., Iwatani, Y. |
None |
| Structural insights into the RNA methyltransferase domain of METTL16. |
Ruszkowska, A., Ruszkowski, M., Dauter, Z., Brown, J.A. |
None |
| Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe |
She, M., Decker, C.J., Chen, N., Tumati, S., Parker, R., Song, H. |
None |
| Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis. |
Spahr, H., Habermann, B., Gustafsson, C.M., Larsson, N.G., Hallberg, B.M. |
None |
| High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain. |
Hofler, S., Lukat, P., Blankenfeldt, W., Carlomagno, T. |
None |
| The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. |
van Tran, N., Ernst, F.G.M., Hawley, B.R., Zorbas, C., Ulryck, N., Hackert, P., Bohnsack, K.E., Bohnsack, M.T., Jaffrey, S.R., Graille, M., Lafontaine, D.L.J. |
None |
| Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation. |
Smietanski, M., Werner, M., Purta, E., Kaminska, K.H., Stepinski, J., Darzynkiewicz, E., Nowotny, M., Bujnicki, J.M. |
None |
| The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site. |
Taylor, A.B., Meyer, B., Leal, B.Z., Kotter, P., Schirf, V., Demeler, B., Hart, P.J., Entian, K.D., Wohnert, J. |
None |
| Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation. |
Smietanski, M., Werner, M., Purta, E., Kaminska, K.H., Stepinski, J., Darzynkiewicz, E., Nowotny, M., Bujnicki, J.M. |
None |
| The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL |
Liu, R.J., Zhou, M., Fang, Z.P., Wang, M., Zhou, X.L., Wang, E.D. |
None |
| Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G. |
Chen, K.M., Harjes, E., Gross, P.J., Fahmy, A., Lu, Y., Shindo, K., Harris, R.S., Matsuo, H. |
None |
| Structure of an archaeal TYW1, the enzyme catalyzing the second step of wye-base biosynthesis |
Goto-Ito, S., Ishii, R., Ito, T., Shibata, R., Fusatomi, E., Sekine, S., Bessho, Y., Yokoyama, S. |
None |
| Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. |
Boniecki, M.T., Freibert, S.A., Muhlenhoff, U., Lill, R., Cygler, M. |
None |
| Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation. |
Goto-Ito, S., Ito, T., Kuratani, M., Bessho, Y., Yokoyama, S. |
None |
| Structural insights into the molecular mechanism of the m(6)A writer complex. |
Sledz, P., Jinek, M. |
None |
| Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase. |
Guelorget, A., Roovers, M., Guerineau, V., Barbey, C., Li, X., Golinelli-Pimpaneau, B. |
None |
| Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing. |
Macbeth, M.R., Schubert, H.L., Vandemark, A.P., Lingam, A.T., Hill, C.P., Bass, B.L. |
None |
| Structural and Dynamic Insights into Redundant Function of YTHDF Proteins. |
Li, Y., Bedi, R.K., Moroz-Omori, E.V., Caflisch, A. |
None |
| Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC. |
Kim, J., Almo, S.C. |
None |
| The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism. |
Schluckebier, G., Zhong, P., Stewart, K.D., Kavanaugh, T.J., Abad-Zapatero, C. |
None |
| tRNAHis guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. |
Hyde, S.J., Eckenroth, B.E., Smith, B.A., Eberley, W.A., Heintz, N.H., Jackman, J.E., Doublie, S. |
None |
| Structure of the Yeast tRNA M7G Methylation Complex. |
Leulliot, N., Chaillet, M., Durand, D., Ulryck, N., Blondeau, K., Van Tilbeurgh, H. |
None |
| Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain. |
Shi, K., Carpenter, M.A., Kurahashi, K., Harris, R.S., Aihara, H. |
None |
| First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G. |
Li, M., Shandilya, S.M., Carpenter, M.A., Rathore, A., Brown, W.L., Perkins, A.L., Harki, D.A., Solberg, J., Hook, D.J., Pandey, K.K., Parniak, M.A., Johnson, J.R., Krogan, N.J., Somasundaran, M., Ali, A., Schiffer, C.A., Harris, R.S. |
None |
| 1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure. |
Shaban, N.M., Shi, K., Li, M., Aihara, H., Harris, R.S. |
None |
| Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4. |
Suzuki, Y., Noma, A., Suzuki, T., Ishitani, R., Nureki, O. |
None |
| Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase |
Chen, H.Y., Yuan, Y.A. |
None |
| Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex |
Wang, X., Feng, J., Xue, Y., Guan, Z., Zhang, D., Liu, Z., Gong, Z., Wang, Q., Huang, J., Tang, C., Zou, T., Yin, P. |
None |
| Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA-sequestering peripheral protein domain |
Hoang, C., Hamilton, C.S., Mueller, E.G., Ferre-D'Amare, A.R. |
None |
| Structural Insights Into Methyltransferase Ksga Function in 30S Ribosomal Subunit Biogenesis |
Boehringer, D., O'Farrell, H.C., Rife, J.P., Ban, N. |
None |
| Human Abh3 Structure and Key Residues for Oxidative Demethylation to Reverse DNA/RNA Damage. |
Sundheim, O., Vagbo, C.B., Bjoras, M., Desousa, M.M.L., Talstad, V., Aas, P.A., Drablos, F., Krokan, H.E., Tainer, J.A., Slupphaug, G. |
None |
| Crystal structure of the RluD pseudouridine Synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli |
Sivaraman, J., Iannuzzi, P., Cygler, M., Matte, A. |
None |
| Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold |
Kaya, Y., Del Campo, M., Ofengand, J., Malhotra, A. |
None |
| Crystal structure of archaeosine tRNA-guanine transglycosylase. |
Ishitani, R., Nureki, O., Fukai, S., Kijimoto, T., Nameki, N., Watanabe, M., Kondo, H., Sekine, M., Okada, N., Nishimura, S., Yokoyama, S. |
None |
| Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus. |
Lima, C.D., Wang, L.K., Shuman, S. |
None |
| The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism. |
Schluckebier, G., Zhong, P., Stewart, K.D., Kavanaugh, T.J., Abad-Zapatero, C. |
None |
| New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1. |
Zong, G., Jork, N., Hostachy, S., Fiedler, D., Jessen, H.J., Shears, S.B., Wang, H. |
None |
| Dimerization of elongator protein 1 is essential for Elongator complex assembly. |
Xu, H., Lin, Z., Li, F., Diao, W., Dong, C., Zhou, H., Xie, X., Wang, Z., Shen, Y., Long, J. |
None |
| Insights into Catalysis by a Knotted TrmD tRNA Methyltransferase. |
Elkins, P.A., Watts, J.M., Zalacain, M., Van Thiel, A., Vitaszka, P.R., Redlak, M., Andraos-Selim, C., Rastinejad, F., Holmes, W.M. |
None |
| Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling. |
Dollins, D.E., Bai, W., Fridy, P.C., Otto, J.C., Neubauer, J.L., Gattis, S.G., Mehta, K.P.M., York, J.D. |
None |
| Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity. |
Byeon, I.J., Byeon, C.H., Wu, T., Mitra, M., Singer, D., Levin, J.G., Gronenborn, A.M. |
None |
| Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling. |
Dollins, D.E., Bai, W., Fridy, P.C., Otto, J.C., Neubauer, J.L., Gattis, S.G., Mehta, K.P.M., York, J.D. |
None |
| Sequence preference and structural heterogeneity of BZ junctions. |
Kim, D., Hur, J., Han, J.H., Ha, S.C., Shin, D., Lee, S., Park, S., Sugiyama, H., Kim, K.K. |
None |
| Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA |
Wang, K.T., Desmolaize, B., Nan, J., Zhang, X.W., Li, L.F., Douthwaite, S., Su, X.D. |
None |
| The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA. |
Schade, M., Turner, C.J., Kuhne, R., Schmieder, P., Lowenhaupt, K., Herbert, A., Rich, A., Oschkinat, H. |
None |
| Structural basis of biological nitrile reduction. |
Chikwana, V.M., Stec, B., Lee, B.W., de Crecy-Lagard, V., Iwata-Reuyl, D., Swairjo, M.A. |
None |
| Architecture of the yeast Elongator complex. |
Dauden, M.I., Kosinski, J., Kolaj-Robin, O., Desfosses, A., Ori, A., Faux, C., Hoffmann, N.A., Onuma, O.F., Breunig, K.D., Beck, M., Sachse, C., Seraphin, B., Glatt, S., Muller, C.W. |
None |
| Structural and Functional Insights Into tRNA Binding and Adenosine N1-Methylation by an Archaeal Trm10 Homologue. |
Van Laer, B., Roovers, M., Wauters, L., Kasprzak, J.M., Dyzma, M., Deyaert, E., Kumar Singh, R., Feller, A., Bujnicki, J.M., Droogmans, L., Versees, W. |
None |
| The elp2 subunit is essential for elongator complex assembly and functional regulation |
Dong, C., Lin, Z., Diao, W., Li, D., Chu, X., Wang, Z., Zhou, H., Xie, Z., Shen, Y., Long, J. |
None |
| Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element. |
Scrima, A., Wittinghofer, A. |
None |
| A cytidine deaminase edits C to U in transfer RNAs in Archaea |
Randau, L., Stanley, B.J., Kohlway, A., Mechta, S., Xiong, Y., Soll, D. |
None |
| Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine. |
Ryu, H., Grove, T.L., Almo, S.C., Kim, J. |
None |
| A Unique RNA Fold in the Ruma-RNA-Cofactor Ternary Complex Contributes to Substrate Selectivity and Enzymatic Function |
Lee, T.T., Agarwalla, S., Stroud, R.M. |
None |
| Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6 |
Liu, R.J., Long, T., Li, J., Li, H., Wang, E.D. |
None |
| Structures of RNA 3'-phosphate cyclase bound to ATP reveal the mechanism of nucleotidyl transfer and metal-assisted catalysis. |
Chakravarty, A.K., Smith, P., Shuman, S. |
None |
| Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. |
Kato, M., Araiso, Y., Noma, A., Nagao, A., Suzuki, T., Ishitani, R., Nureki, O. |
None |
| Major Reorientation of tRNA Substrates Defines Specificity of Dihydrouridine Synthases. |
Byrne, R.T., Jenkins, H.T., Peters, D.T., Whelan, F., Stowell, J., Aziz, N., Kasatsky, P., Rodnina, M.V., Koonin, E.V., Konevega, A.L., Antson, A.A. |
None |
| Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA |
Lu, X., Zhang, T., Xu, Z., Liu, S., Zhao, B., Lan, W., Wang, C., Ding, J., Cao, C. |
None |
| Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. |
Wang, P., Doxtader, K.A., Nam, Y. |
None |
| Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces. |
Shandilya, S.M., Nalam, M.N., Nalivaika, E.A., Gross, P.J., Valesano, J.C., Shindo, K., Li, M., Munson, M., Royer, W.E., Harjes, E., Kono, T., Matsuo, H., Harris, R.S., Somasundaran, M., Schiffer, C.A. |
None |
| The structures of non-CG-repeat Z-DNAs co-crystallized with the Z-DNA-binding domain, hZ{alpha}ADAR1 |
Ha, S.C., Choi, J., Hwang, H.Y., Rich, A., Kim, Y.G., Kim, K.K. |
None |
| Crystal structure of IscA, an iron-sulfur cluster assembly protein from Escherichia coli. |
Cupp-Vickery, J.R., Silberg, J.J., Ta, D.T., Vickery, L.E. |
None |
| Structure of H/ACA RNP Protein Nhp2p Reveals Cis/Trans Isomerization of a Conserved Proline at the RNA and Nop10 Binding Interface. |
Koo, B.K., Park, C.J., Fernandez, C.F., Chim, N., Ding, Y., Chanfreau, G., Feigon, J. |
None |
| In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities. |
Czudnochowski, N., Wang, A.L., Finer-Moore, J., Stroud, R.M. |
None |
| Crystal Structure of the Nosiheptide-Resistance Methyltransferase of Streptomyces actuosus |
Yang, H., Wang, Z., Shen, Y., Wang, P., Jia, X., Zhao, L., Zhou, P., Gong, R., Li, Z., Yang, Y., Chen, D., Murchie, A.I.H., Xu, Y. |
None |
| Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA. |
Ren, W., Lu, J., Huang, M., Gao, L., Li, D., Wang, G.G., Song, J. |
None |
| Structure of the Saccharomyces cerevisiae Cet1-Ceg1 mRNA Capping Apparatus. |
Gu, M., Rajashankar, K.R., Lima, C.D. |
None |
| Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases. |
Bou-Nader, C., Bregeon, D., Pecqueur, L., Fontecave, M., Hamdane, D. |
None |
| Structure and function of the bacterial decapping enzyme NudC |
Hofer, K., Li, S., Abele, F., Frindert, J., Schlotthauer, J., Grawenhoff, J., Du, J., Patel, D.J., Jaschke, A. |
None |
| The Crystal Structure of Pyrococcus Abyssi tRNA (Uracil-54, C5)-Methyltransferase Provides Insights Into its tRNA Specificity. |
Walbott, H., Leulliot, N., Grosjean, H., Golinelli-Pimpaneau, B. |
None |
| Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus. |
Lima, C.D., Wang, L.K., Shuman, S. |
None |
| Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC |
Sunita, S., Purta, E., Durawa, M., Tkaczuk, K.L., Swaathi, J., Bujnicki, J.M., Sivaraman, J. |
None |
| Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism. |
Fox, N.G., Yu, X., Feng, X., Bailey, H.J., Martelli, A., Nabhan, J.F., Strain-Damerell, C., Bulawa, C., Yue, W.W., Han, S. |
None |
| Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome. |
Lau, B., Cheng, J., Flemming, D., La Venuta, G., Berninghausen, O., Beckmann, R., Hurt, E. |
None |
| Crystal Structure of the Human tRNA Guanine Transglycosylase Catalytic Subunit QTRT1. |
Johannsson, S., Neumann, P., Ficner, R. |
None |
| Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase |
Nishimasu, H., Ishitani, R., Yamashita, K., Iwashita, C., Hirata, A., Hori, H., Nureki, O. |
None |
| Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA. |
Dunkle, J.A., Vinal, K., Desai, P.M., Zelinskaya, N., Savic, M., West, D.M., Conn, G.L., Dunham, C.M. |
None |
| Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria. |
Bussiere, D.E., Muchmore, S.W., Dealwis, C.G., Schluckebier, G., Nienaber, V.L., Edalji, R.P., Walter, K.A., Ladror, U.S., Holzman, T.F., Abad-Zapatero, C. |
None |
| Crystal Structure of tRNA N(2),N(2)-Guanosine Dimethyltransferase Trm1 from Pyrococcus horikoshii |
Ihsanawati, Nishimoto, M., Higashijima, K., Shirouzu, M., Grosjean, H., Bessho, Y., Yokoyama, S. |
None |
| Structural and Functional Insights Into the Molecular Mechanism of Rrna M6A Methyltransferase Rlmj. |
Punekar, A.S., Liljeruhm, J., Shepherd, T.R., Forster, A.C., Selmer, M. |
None |
| Crystallographic snapshots of eukaryotic dimethylallyltransferase acting on tRNA: insight into tRNA recognition and reaction mechanism. |
Zhou, C., Huang, R.H. |
None |
| Structure-function analysis of Escherichia coli MnmG (GidA), a highly conserved tRNA-modifying enzyme. |
Shi, R., Villarroya, M., Ruiz-Partida, R., Li, Y., Proteau, A., Prado, S., Moukadiri, I., Benitez-Paez, A., Lomas, R., Wagner, J., Matte, A., Velazquez-Campoy, A., Armengod, M.E., Cygler, M. |
None |
| Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins. |
Thirawatananond, P., McPherson, R.L., Malhi, J., Nathan, S., Lambrecht, M.J., Brichacek, M., Hergenrother, P.J., Leung, A.K.L., Gabelli, S.B. |
None |
| Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. |
Liu, X., Shen, S., Wu, P., Li, F., Liu, X., Wang, C., Gong, Q., Wu, J., Yao, X., Zhang, H., Shi, Y. |
None |
| Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine. |
Demirci, H., Belardinelli, R., Seri, E., Gregory, S.T., Gualerzi, C., Dahlberg, A.E., Jogl, G. |
None |
| Characterization of Two Homologous 2'-O-Methyltransferases Showing Different Specificities for Their tRNA Substrates. |
Somme, J., Van Laer, B., Roovers, M., Steyaert, J., Versees, W., Droogmans, L. |
None |
| Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle. |
Xue, S., Wang, R., Yang, F., Terns, R.M., Terns, M.P., Zhang, X., Maxwell, E.S., Li, H. |
None |
| Substrate tRNA recognition mechanism of a multisite-specific tRNA methyltransferase, Aquifex aeolicus Trm1, based on the X-ray crystal structure |
Awai, T., Ochi, A., Ihsanawati, Sengoku, T., Hirata, A., Bessho, Y., Yokoyama, S., Hori, H. |
None |
| The Crystal Structure of the Z[beta] Domain of the RNA-editing Enzyme ADAR1 Reveals Distinct Conserved Surfaces Among Z-domains. |
Athanasiadis, A., Placido, D., Maas, S., Brown II, B.A., Lowenhaupt, K., Rich, A. |
None |
| Structure of the Kti11/Kti13 Heterodimer and its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2. |
Glatt, S., Zabel, R., Vonkova, I., Kumar, A., Netz, D.J., Pierik, A.J., Rybin, V., Lill, R., Gavin, A., Balbach, J., Breunig, K.D., Muller, C.W. |
None |
| Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer. |
Bedi, R.K., Huang, D., Eberle, S.A., Wiedmer, L., Sledz, P., Caflisch, A. |
None |
| Structure of the guanylyltransferase domain of human mRNA capping enzyme. |
Chu, C., Das, K., Tyminski, J.R., Bauman, J.D., Guan, R., Qiu, W., Montelione, G.T., Arnold, E., Shatkin, A.J. |
None |
| Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function |
Kim, J., Xiao, H., Bonanno, J.B., Kalyanaraman, C., Brown, S., Tang, X., Al-Obaidi, N.F., Patskovsky, Y., Babbitt, P.C., Jacobson, M.P., Lee, Y.-S., Almo, S.C. |
None |
| The crystal structure of the Methanocaldococcus jannaschii multifunctional L7Ae RNA-binding protein reveals an induced-fit interaction with the box C/D RNAs. |
Suryadi, J., Tran, E.J., Maxwell, E.S., Brown, B.A. |
None |
| Sequence preference and structural heterogeneity of BZ junctions. |
Kim, D., Hur, J., Han, J.H., Ha, S.C., Shin, D., Lee, S., Park, S., Sugiyama, H., Kim, K.K. |
None |
| Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. |
Holden, L.G., Prochnow, C., Chang, Y.P., Bransteitter, R., Chelico, L., Sen, U., Stevens, R.C., Goodman, M.F., Chen, X.S. |
None |
| Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. |
Mao, D.Y., Neculai, D., Downey, M., Orlicky, S., Haffani, Y.Z., Ceccarelli, D.F., Ho, J.S., Szilard, R.K., Zhang, W., Ho, C.S., Wan, L., Fares, C., Rumpel, S., Kurinov, I., Arrowsmith, C.H., Durocher, D., Sicheri, F. |
None |
| Crystal structure of the catalytic domain of RluD, the only rRNA pseudouridine synthase required for normal growth of Escherichia coli |
Del Campo, M., Ofengand, J., Malhotra, A. |
None |
| High-resolution structures of the SARS-CoV-2 2'- O -methyltransferase reveal strategies for structure-based inhibitor design. |
Rosas-Lemus, M., Minasov, G., Shuvalova, L., Inniss, N.L., Kiryukhina, O., Brunzelle, J., Satchell, K.J.F. |
None |
| Crystal structures of the catalytic domains of pseudouridine synthases RluC and RluD from Escherichia coli |
Mizutani, K., Machida, Y., Unzai, S., Park, S.-Y., Tame, J.R.H. |
None |
| The Crystal Structure of Pyrococcus Abyssi tRNA (Uracil-54, C5)-Methyltransferase Provides Insights Into its tRNA Specificity. |
Walbott, H., Leulliot, N., Grosjean, H., Golinelli-Pimpaneau, B. |
None |
| Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. |
Kato, M., Araiso, Y., Noma, A., Nagao, A., Suzuki, T., Ishitani, R., Nureki, O. |
None |
| Structural insights into mechanisms of the small RNA methyltransferase HEN1. |
Huang, Y., Ji, L., Huang, Q., Vassylyev, D.G., Chen, X., Ma, J.B. |
None |
| Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator. |
Ye, Q., Ur, S.N., Su, T.Y., Corbett, K.D. |
None |
| Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme. |
Liu, C., Shi, W., Becker, S.T., Schatz, D.G., Liu, B., Yang, Y. |
None |
| Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development. |
Mendel, M., Chen, K.M., Homolka, D., Gos, P., Pandey, R.R., McCarthy, A.A., Pillai, R.S. |
None |
| Crystal structure of a fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution. |
Wang, H., Boisvert, D., Kim, K.K., Kim, R., Kim, S.H. |
None |
| Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA Recognition Through a Combination of Rigid Docking and Induced Fit |
Pan, H., Agarwalla, S., Moustakas, D.T., Finer-Moore, J., Stroud, R.M. |
None |
| Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions. |
Shi, R., Proteau, A., Villarroya, M., Moukadiri, I., Zhang, L., Trempe, J.F., Matte, A., Armengod, M.E., Cygler, M. |
None |
| Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. |
Dong, A., Yoder, J.A., Zhang, X., Zhou, L., Bestor, T.H., Cheng, X. |
None |
| Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure |
Hoang, C., Chen, J., Vizthum, C.A., Kandel, J.M., Hamilton, C.S., Mueller, E.G., Ferre-D'Amare, A.R. |
None |
| Crystal Structure of Human Pus10, a Novel Pseudouridine Synthase. |
Mccleverty, C.J., Hornsby, M., Spraggon, G., Kreusch, A. |
None |
| Dual conformational recognition by Z-DNA binding protein is important for the B-Z transition process. |
Park, C., Zheng, X., Park, C.Y., Kim, J., Lee, S.K., Won, H., Choi, J., Kim, Y.G., Choi, H.J. |
None |
| Structural basis of tRNA agmatinylation essential for AUA codon decoding |
Osawa, T., Kimura, S., Terasaka, N., Inanaga, H., Suzuki, T., Numata, T. |
None |
| Structure of the Essential MTERF4:NSUN4 Protein Complex Reveals How an MTERF Protein Collaborates to Facilitate rRNA Modification. |
Yakubovskaya, E., Guja, K.E., Mejia, E., Castano, S., Hambardjieva, E., Choi, W.S., Garcia-Diaz, M. |
None |
| The Crystal Structure and Small-Angle X-Ray Analysis of Csdl/Tcda Reveal a New tRNA Binding Motif in the Moeb/E1 Superfamily. |
Lopez-Estepa, M., Arda, A., Savko, M., Round, A., Shepard, W.E., Bruix, M., Coll, M., Fernandez, F.J., Jimenez-Barbero, J., Vega, M.C. |
None |
| The Structure of the Rlmb 23S Rrna Methyltransferase Reveals a New Methyltransferase Fold with a Unique Knot |
Michel, G., Sauve, V., Larocque, R., Li, Y., Matte, A., Cygler, M. |
None |
| Analysis of GTP addition in the reverse (3'-5') direction by human tRNA His guanylyltransferase. |
Nakamura, A., Wang, D., Komatsu, Y. |
None |
| Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification. |
Pham, P., Afif, S.A., Shimoda, M., Maeda, K., Sakaguchi, N., Pedersen, L.C., Goodman, M.F. |
None |
| Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics |
Kissinger, C.R., Rejto, P.A., Pelletier, L.A., Thomson, J.A., Showalter, R.E., Abreo, M.A., Agree, C.S., Margosiak, S., Meng, J.J., Aust, R.M., Vanderpool, D., Li, B., Tempczyk-Russell, A., Villafranca, J.E. |
None |
| Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B. |
Shi, K., Carpenter, M.A., Banerjee, S., Shaban, N.M., Kurahashi, K., Salamango, D.J., McCann, J.L., Starrett, G.J., Duffy, J.V., Demir, O., Amaro, R.E., Harki, D.A., Harris, R.S., Aihara, H. |
None |
| Structure of Saccharomyces cerevisiae mitochondrial Qri7 in complex with AMP |
Tominaga, T., Kobayashi, K., Ishii, R., Ishitani, R., Nureki, O. |
None |
| Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. |
Finer-Moore, J., Czudnochowski, N., O'Connell, J.D., Wang, A.L., Stroud, R.M. |
None |
| Characterization and structure of the Aquifex aeolicus protein DUF752: a bacterial tRNA-methyltransferase (MnmC2) functioning without the usually fused oxidase domain (MnmC1) |
Kitamura, A., Nishimoto, M., Sengoku, T., Shibata, R., Jager, G., Bjork, G.R., Grosjean, H., Yokoyama, S., Bessho, Y. |
None |
| Crystal Structure of the Avilamycin Resistance-Conferring Methyltransferase Avira from Streptomyces Viridochromogenes |
Mosbacher, T.G., Bechthold, A., Schulz, G.E. |
None |
| The Crystal Structure of E. coli rRNA Pseudouridine Synthase RluE. |
Pan, H., Ho, J.D., Stroud, R.M., Finer-Moore, J. |
None |
| The Escherichia coli YadB gene product reveals a novel aminoacyl-tRNA synthetase like activity. |
Campanacci, V., Dubois, D.Y., Becker, H.D., Kern, D., Spinelli, S., Valencia, C., Pagot, F., Salomoni, A., Grisel, S., Vincentelli, R., Bignon, C., Lapointe, J., Giege, R., Cambillau, C. |
None |
| Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2 |
Umitsu, M., Nishimasu, H., Noma, A., Suzuki, T., Ishitani, R., Nureki, O. |
None |
| Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. |
Liu, X., Shen, S., Wu, P., Li, F., Liu, X., Wang, C., Gong, Q., Wu, J., Yao, X., Zhang, H., Shi, Y. |
None |
| Structures of RNA 3'-phosphate cyclase bound to ATP reveal the mechanism of nucleotidyl transfer and metal-assisted catalysis. |
Chakravarty, A.K., Smith, P., Shuman, S. |
None |
| Structural and Functional Insights Into tRNA Binding and Adenosine N1-Methylation by an Archaeal Trm10 Homologue. |
Van Laer, B., Roovers, M., Wauters, L., Kasprzak, J.M., Dyzma, M., Deyaert, E., Kumar Singh, R., Feller, A., Bujnicki, J.M., Droogmans, L., Versees, W. |
None |
| The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs. |
Hamma, T., Reichow, S.L., Varani, G., Ferre-D'Amare, A.R. |
None |
| Box C/D guide RNAs recognize a maximum of 10 nt of substrates |
Yang, Z., Lin, J., Ye, K. |
None |
| Alternative Tertiary Structure of tRNA for Recognition by a Posttranscriptional Modification Enzyme |
Ishitani, R., Nureki, O., Nameki, N., Okada, N., Nishimura, S., Yokoyama, S. |
None |
| Differentiating analogous tRNA methyltransferases by fragments of the methyl donor. |
Lahoud, G., Goto-Ito, S., Yoshida, K., Ito, T., Yokoyama, S., Hou, Y.M. |
None |
| Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase reveal aspartate 102 as the active site nucleophile. |
Romier, C., Reuter, K., Suck, D., Ficner, R. |
None |
| Understanding the Structure, Multimerization, Subcellular Localization and mC Selectivity of a Genomic Mutator and Anti-HIV Factor APOBEC3H. |
Ito, F., Yang, H., Xiao, X., Li, S.X., Wolfe, A., Zirkle, B., Arutiunian, V., Chen, X.S. |
None |
| Crystal structures of the conserved tRNA-modifying enzyme GidA: implications for its interaction with MnmE and substrate |
Meyer, S., Scrima, A., Versees, W., Wittinghofer, A. |
None |
| Snapshots of dynamics in synthesizing N(6)-isopentenyladenosine at the tRNA anticodon |
Chimnaronk, S., Forouhar, F., Sakai, J., Yao, M., Tron, C.M., Atta, M., Fontecave, M., Hunt, J.F., Tanaka, I. |
None |
| The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain |
Hallberg, B.M., Ericsson, U.B., Johnson, K.A., Andersen, N.M., Douthwaite, S., Nordlund, P., Beuscher IV, A.E., Erlandsen, H. |
None |
| Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases. |
Husain, N., Tkaczuk, K.L., Tulsidas, S.R., Kaminska, K.H., Cubrilo, S., Maravic-Vlahovicek, G., Bujnicki, J.M., Sivaraman, J. |
None |
| Crystal structure of the highly divergent pseudouridine synthase TruD reveals a circular permutation of a conserved fold. |
Hoang, C., Ferre-D'Amare, A.R. |
None |
| Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase. |
Guelorget, A., Roovers, M., Guerineau, V., Barbey, C., Li, X., Golinelli-Pimpaneau, B. |
None |
| Structure of the thiostrepton-resistance methyltransferase-S-adenosyl-L-methionine complex and its interaction with ribosomal RNA |
Dunstan, M.S., Hang, P.C., Zelinskaya, N.V., Honek, J.F., Conn, G.L. |
None |
| Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity. |
Lin, S., Chen, H., Chen, Z., Yang, F., Ye, F., Zheng, Y., Yang, J., Lin, X., Sun, H., Wang, L., Wen, A., Dong, H., Xiao, Q., Deng, D., Cao, Y., Lu, G. |
None |
| Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. |
Demirci, H., Larsen, L.H., Hansen, T., Rasmussen, A., Cadambi, A., Gregory, S.T., Kirpekar, F., Jogl, G. |
None |
| A Complement to the Modern Crystallographer'S Toolbox: Caged Gadolinium Complexes with Versatile Binding Modes. |
Stelter, M., Molina, R., Jeudy, S., Kahn, R., Abergel, C., Hermoso, J.A. |
None |
| Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA. |
Schwartz, T., Rould, M.A., Lowenhaupt, K., Herbert, A., Rich, A. |
None |
| Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G |
Furukawa, A., Nagata, T., Matsugami, A., Habu, Y., Sugiyama, R., Hayashi, F., Kobayashi, N., Yokoyama, S., Takaku, H., Katahira, M. |
None |
| Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. |
Aik, W., Scotti, J.S., Choi, H., Gong, L., Demetriades, M., Schofield, C.J., McDonough, M.A. |
None |
| Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. |
Mao, D.Y., Neculai, D., Downey, M., Orlicky, S., Haffani, Y.Z., Ceccarelli, D.F., Ho, J.S., Szilard, R.K., Zhang, W., Ho, C.S., Wan, L., Fares, C., Rumpel, S., Kurinov, I., Arrowsmith, C.H., Durocher, D., Sicheri, F. |
None |
| Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery. |
Gakh, O., Ranatunga, W., Smith, D.Y., Ahlgren, E.C., Al-Karadaghi, S., Thompson, J.R., Isaya, G. |
None |
| Structural and Functional Insights Into the Molecular Mechanism of Rrna M6A Methyltransferase Rlmj. |
Punekar, A.S., Liljeruhm, J., Shepherd, T.R., Forster, A.C., Selmer, M. |
None |
| Crystal Structure of Thermus thermophilus tRNA m(1)A(58) Methyltransferase and Biophysical Characterization of Its Interaction with tRNA. |
Barraud, P., Golinelli-Pimpaneau, B., Atmanene, C., Sanglier, S., Van Dorsselaer, A., Droogmans, L., Dardel, F., Tisne, C. |
None |
| Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation |
Goto-Ito, S., Ito, T., Kuratani, M., Bessho, Y., Yokoyama, S. |
None |
| Crystal structures of the conserved tRNA-modifying enzyme GidA: implications for its interaction with MnmE and substrate |
Meyer, S., Scrima, A., Versees, W., Wittinghofer, A. |
None |
| Mechanistic insights into m6A modification of U6 snRNA by human METTL16. |
Aoyama, T., Yamashita, S., Tomita, K. |
None |
| Crystal structure of the human PRPK-TPRKB complex. |
Li, J., Ma, X., Banerjee, S., Chen, H., Ma, W., Bode, A.M., Dong, Z. |
None |
| Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. |
Xu, C., Liu, K., Tempel, W., Demetriades, M., Aik, W., Schofield, C.J., Min, J. |
None |
| Structure of D-tyrosyl-tRNATyr deacylase using home-source Cu Kalpha and moderate-quality iodide-SAD data: structural polymorphism and HEPES-bound enzyme states |
Yogavel, M., Khan, S., Bhatt, T.K., Sharma, A. |
None |
| Sinorhizobium meliloti YrbA binds divalent metal cations using two conserved histidines. |
Roret, T., Alloing, G., Girardet, J.M., Perrot, T., Dhalleine, T., Couturier, J., Frendo, P., Didierjean, C., Rouhier, N. |
None |
| Kissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopy |
Meyer, S., Bohme, S., Kruger, A., Steinhoff, H.-J., Klare, J.P., Wittinghofer, A. |
None |
| Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit. |
Husain, N., Obranic, S., Koscinski, L., Seetharaman, J., Babic, F., Bujnicki, J.M., Maravic-Vlahovicek, G., Sivaraman, J. |
None |
| Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity |
Gu, M., Fabrega, C., Liu, S.W., Liu, H., Kiledjian, M., Lima, C.D. |
None |
| Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. |
Wang, P., Doxtader, K.A., Nam, Y. |
None |
| The APOBEC-2 crystal structure and functional implications for the deaminase AID. |
Prochnow, C., Bransteitter, R., Klein, M.G., Goodman, M.F., Chen, X.S. |
None |
| Crystal Structure of tRNA N(2),N(2)-Guanosine Dimethyltransferase Trm1 from Pyrococcus horikoshii |
Ihsanawati, Nishimoto, M., Higashijima, K., Shirouzu, M., Grosjean, H., Bessho, Y., Yokoyama, S. |
None |
| Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases |
Schmitt, E., Galimand, M., Panvert, M., Courvalin, P., Mechulam, Y. |
None |
| Crystal structure of ErmE - 23S rRNA methyltransferase in macrolide resistance. |
Stsiapanava, A., Selmer, M. |
None |
| Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. |
Yan, L., Ge, J., Zheng, L., Zhang, Y., Gao, Y., Wang, T., Huang, Y., Yang, Y., Gao, S., Li, M., Liu, Z., Wang, H., Li, Y., Chen, Y., Guddat, L.W., Wang, Q., Rao, Z., Lou, Z. |
None |
| Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions. |
Shi, R., Proteau, A., Villarroya, M., Moukadiri, I., Zhang, L., Trempe, J.F., Matte, A., Armengod, M.E., Cygler, M. |
None |
| Snapshots of tRNA sulphuration via an adenylated intermediate |
Numata, T., Ikeuchi, Y., Fukai, S., Suzuki, T., Nureki, O. |
None |
| Crystal structure of the FTO protein reveals basis for its substrate specificity |
Han, Z., Niu, T., Chang, J., Lei, X., Zhao, M., Wang, Q., Cheng, W., Wang, J., Feng, Y., Chai, J. |
None |
| Conserved cysteine residues of GidA are essential for biogenesis of 5-carboxymethylaminomethyluridine at tRNA anticodon |
Osawa, T., Ito, K., Inanaga, H., Nureki, O., Tomita, K., Numata, T. |
None |
| ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. |
Lustbader, J.W., Cirilli, M., Lin, C., Xu, H.W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., Trinchese, F., Gunn-Moore, F., Lue, L.F., Walker, D.G., Kuppusamy, P., Zewier, Z.L., Arancio, O., Stern, D., Yan, S.S., Wu, H. |
None |
| Identification and Characterization of the Thermus thermophilus 5-Methylcytidine (m5C) Methyltransferase Modifying 23 S Ribosomal RNA (rRNA) Base C1942. |
Larsen, L.H., Rasmussen, A., Giessing, A.M., Jogl, G., Kirpekar, F. |
None |
| Structure of Protein L7Ae Bound to a K-Turn Derived from an Archaeal Box H/ACA sRNA at 1.8 A Resolution. |
Hamma, T., Ferre-D'Amare, A. |
None |
| The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I. |
Foster, P.G., Huang, L., Santi, D.V., Stroud, R.M. |
None |
| Structural basis of antagonism of human APOBEC3F by HIV-1 Vif. |
Hu, Y., Desimmie, B.A., Nguyen, H.C., Ziegler, S.J., Cheng, T.C., Chen, J., Wang, J., Wang, H., Zhang, K., Pathak, V.K., Xiong, Y. |
None |
| Crystal Structure of Ruma, an Iron-Sulfur Cluster Containing E. Coli Ribosomal RNA 5-Methyluridine Methyltransferase. |
Lee, T.T., Agarwalla, S., Stroud, R.M. |
None |
| Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit. |
Husain, N., Obranic, S., Koscinski, L., Seetharaman, J., Babic, F., Bujnicki, J.M., Maravic-Vlahovicek, G., Sivaraman, J. |
None |
| Conserved cysteine residues of GidA are essential for biogenesis of 5-carboxymethylaminomethyluridine at tRNA anticodon |
Osawa, T., Ito, K., Inanaga, H., Nureki, O., Tomita, K., Numata, T. |
None |
| NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity. |
Byeon, I.J., Ahn, J., Mitra, M., Byeon, C.H., Hercik, K., Hritz, J., Charlton, L.M., Levin, J.G., Gronenborn, A.M. |
None |
| Structural insights into the molecular mechanism of the m(6)A writer complex. |
Sledz, P., Jinek, M. |
None |
| Defects in t 6 A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome. |
Arrondel, C., Missoury, S., Snoek, R., Patat, J., Menara, G., Collinet, B., Liger, D., Durand, D., Gribouval, O., Boyer, O., Buscara, L., Martin, G., Machuca, E., Nevo, F., Lescop, E., Braun, D.A., Boschat, A.C., Sanquer, S., Guerrera, I.C., Revy, P., Parisot, M., Masson, C., Boddaert, N., Charbit, M., Decramer, S., Novo, R., Macher, M.A., Ranchin, B., Bacchetta, J., Laurent, A., Collardeau-Frachon, S., van Eerde, A.M., Hildebrandt, F., Magen, D., Antignac, C., van Tilbeurgh, H., Mollet, G. |
None |
| RNA-Protein Mutually Induced Fit: STRUCTURE OF ESCHERICHIA COLI ISOPENTENYL-tRNA TRANSFERASE IN COMPLEX WITH tRNA(Phe). |
Seif, E., Hallberg, B.M. |
None |
| Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase |
Nishimasu, H., Ishitani, R., Yamashita, K., Iwashita, C., Hirata, A., Hori, H., Nureki, O. |
None |
| Structure of Nucleophosmin DNA-binding Domain and Analysis of Its Complex with a G-quadruplex Sequence from the c-MYC Promoter. |
Gallo, A., Lo Sterzo, C., Mori, M., Di Matteo, A., Bertini, I., Banci, L., Brunori, M., Federici, L. |
None |
| Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification. |
Kim, J., Xiao, H., Koh, J., Wang, Y., Bonanno, J.B., Thomas, K., Babbitt, P.C., Brown, S., Lee, Y.S., Almo, S.C. |
None |
| tRNAHis guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. |
Hyde, S.J., Eckenroth, B.E., Smith, B.A., Eberley, W.A., Heintz, N.H., Jackman, J.E., Doublie, S. |
None |
| Solution structure of an rRNA methyltransferase (ErmAM) that confers macrolide-lincosamide-streptogramin antibiotic resistance. |
Yu, L., Petros, A.M., Schnuchel, A., Zhong, P., Severin, J.M., Walter, K., Holzman, T.F., Fesik, S.W. |
None |
| Structure of the RNA 3'-phosphate cyclase-adenylate intermediate illuminates nucleotide specificity and covalent nucleotidyl transfer. |
Tanaka, N., Smith, P., Shuman, S. |
None |
| First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G. |
Li, M., Shandilya, S.M., Carpenter, M.A., Rathore, A., Brown, W.L., Perkins, A.L., Harki, D.A., Solberg, J., Hook, D.J., Pandey, K.K., Parniak, M.A., Johnson, J.R., Krogan, N.J., Somasundaran, M., Ali, A., Schiffer, C.A., Harris, R.S. |
None |
| Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain. |
Shi, K., Carpenter, M.A., Kurahashi, K., Harris, R.S., Aihara, H. |
None |
| High-resolution structures of the SARS-CoV-2 2'- O -methyltransferase reveal strategies for structure-based inhibitor design. |
Rosas-Lemus, M., Minasov, G., Shuvalova, L., Inniss, N.L., Kiryukhina, O., Brunzelle, J., Satchell, K.J.F. |
None |
| Crystal structure of the bifunctional tRNA modification enzyme MnmC from Escherichia coli |
Kitamura, A., Sengoku, T., Nishimoto, M., Yokoyama, S., Bessho, Y. |
None |
| The Elongator Subcomplex Elp456 is a Hexameric Reca-Like ATPase. |
Glatt, S., Letoquart, J., Faux, C., Taylor, N.M.I., Seraphin, B., Muller, C.W. |
None |
| Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA. |
Maiti, A., Myint, W., Kanai, T., Delviks-Frankenberry, K., Sierra Rodriguez, C., Pathak, V.K., Schiffer, C.A., Matsuo, H. |
None |
| Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases. |
Byrne, R.T., Jenkins, H.T., Peters, D.T., Whelan, F., Stowell, J., Aziz, N., Kasatsky, P., Rodnina, M.V., Koonin, E.V., Konevega, A.L., Antson, A.A. |
None |
| Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition |
Feng, C., Liu, Y., Wang, G., Deng, Z., Zhang, Q., Wu, W., Tong, Y., Cheng, C., Chen, Z. |
None |
| Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. |
Liu, S., Li, P., Dybkov, O., Nottrott, S., Hartmuth, K., Luhrmann, R., Carlomagno, T., Wahl, M.C. |
None |
| A Left-Handed RNA Double Helix Bound by the Zalpha Domain of the RNA-Editing Enzyme ADAR1. |
Placido, D., Brown, B.A., Lowenhaupt, K., Rich, A., Athanasiadis, A. |
None |
| Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome. |
Alian, A., DeGiovanni, A., Griner, S.L., Finer-Moore, J.S., Stroud, R.M. |
None |
| Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1. |
Tian, L.F., Liu, Y.P., Chen, L., Tang, Q., Wu, W., Sun, W., Chen, Z., Yan, X.X. |
None |
| Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies. |
Ziegler, S.J., Liu, C., Landau, M., Buzovetsky, O., Desimmie, B.A., Zhao, Q., Sasaki, T., Burdick, R.C., Pathak, V.K., Anderson, K.S., Xiong, Y. |
None |
| The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL |
Liu, R.J., Zhou, M., Fang, Z.P., Wang, M., Zhou, X.L., Wang, E.D. |
None |
| Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition |
Feng, C., Liu, Y., Wang, G., Deng, Z., Zhang, Q., Wu, W., Tong, Y., Cheng, C., Chen, Z. |
None |
| Structure of the Kti11/Kti13 Heterodimer and its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2. |
Glatt, S., Zabel, R., Vonkova, I., Kumar, A., Netz, D.J., Pierik, A.J., Rybin, V., Lill, R., Gavin, A., Balbach, J., Breunig, K.D., Muller, C.W. |
None |
| The Crystal Structure of the Methanocaldococcus jannaschii Multifunctional L7Ae RNA-Binding Protein Reveals an Induced-Fit Interaction with the Box C/D RNAs. |
Suryadi, J., Tran, E.J., Maxwell, E.S., Brown II, B.A. |
None |
| X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold |
Ericsson, U.B., Nordlund, P., Hallberg, B.M. |
None |
| Crystal Structure of RNA 3'-Terminal Phosphate Cyclase, a Ubiquitous Enzyme with Unusual Topology |
Palm, G.J., Billy, E., Filipowicz, W., Wlodawer, A. |
None |
| Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life. |
Fislage, M., Roovers, M., Tuszynska, I., Bujnicki, J.M., Droogmans, L., Versees, W. |
None |
| hLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin of 7SK RNA. |
Eichhorn, C.D., Chug, R., Feigon, J. |
None |
| Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator. |
Ye, Q., Ur, S.N., Su, T.Y., Corbett, K.D. |
None |
| Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1. |
Monecke, T., Dickmanns, A., Ficner, R. |
None |
| Comparative analysis of the 15.5kD box C/D snoRNP core protein in the primitive eukaryote Giardia lamblia reveals unique structural and functional features. |
Biswas, S., Buhrman, G., Gagnon, K., Mattos, C., Brown, B.A., Maxwell, E.S. |
None |
| Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain. |
Nakanishi, K., Fukai, S., Ikeuchi, Y., Soma, A., Sekine, Y., Suzuki, T., Nureki, O. |
None |
| Structural basis of 7SK RNA 5'-gamma-phosphate methylation and retention by MePCE. |
Yang, Y., Eichhorn, C.D., Wang, Y., Cascio, D., Feigon, J. |
None |
| A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1. |
Barraud, P., Banerjee, S., Mohamed, W.I., Jantsch, M.F., Allain, F.H. |
None |
| Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases. |
Pulicherla, N., Pogorzala, L.A., Xu, Z., O Farrell, H.C., Musayev, F.N., Scarsdale, J.N., Sia, E.A., Culver, G.M., Rife, J.P. |
None |
| An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model |
Harjes, E., Gross, P.J., Chen, K.M., Lu, Y., Shindo, K., Nowarski, R., Gross, J.D., Kotler, M., Harris, R.S., Matsuo, H. |
None |
| Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins. |
Xu, C., Liu, K., Ahmed, H., Loppnau, P., Schapira, M., Min, J. |
None |
| DrosophilaYBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs. |
Zou, F., Tu, R., Duan, B., Yang, Z., Ping, Z., Song, X., Chen, S., Price, A., Li, H., Scott, A., Perera, A., Li, S., Xie, T. |
None |
| Crystal Structure of IscS, a Cysteine Desulfurase from Escherichia coli |
Cupp-Vickery, J.R., Urbina, H., Vickery, L.E. |
None |
| Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA. |
Yan, X., Lan, W., Wang, C., Cao, C. |
None |
| Molecular Interactions of a DNA Modifying Enzyme APOBEC3F Catalytic Domain with a Single-Stranded DNA. |
Fang, Y., Xiao, X., Li, S.X., Wolfe, A., Chen, X.S. |
None |
| Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita |
Li, S., Duan, J., Li, D., Ma, S., Ye, K. |
None |
| Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase. |
Newman, J.A., Douangamath, A., Yadzani, S., Yosaatmadja, Y., Aimon, A., Brandao-Neto, J., Dunnett, L., Gorrie-Stone, T., Skyner, R., Fearon, D., Schapira, M., von Delft, F., Gileadi, O. |
None |
| How U38, 39, and 40 of Many tRNAs Become the Targets for Pseudouridylation by TruA. |
Hur, S., Stroud, R.M. |
None |
| Molecular Basis of Box C/D RNA-Protein Interactions; Cocrystal Structure of Archaeal L7Ae and a Box C/D RNA. |
Moore, T., Zhang, Y., Fenley, M.O., Li, H. |
None |
| Snapshots of tRNA sulphuration via an adenylated intermediate |
Numata, T., Ikeuchi, Y., Fukai, S., Suzuki, T., Nureki, O. |
None |
| Steroid Receptor RNA Activator (SRA) Modification by the Human Pseudouridine Synthase 1 (hPus1p): RNA Binding, Activity, and Atomic Model |
Huet, T., Miannay, F.-A., Patton, J.R., Thore, S. |
None |
| 1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure. |
Shaban, N.M., Shi, K., Li, M., Aihara, H., Harris, R.S. |
None |
| Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA |
Khanna, M., Wu, H., Johansson, C., Caizergues-Ferrer, M., Feigon, J. |
None |
| Crystal structure of elongator subcomplex Elp4-6 |
Lin, Z., Zhao, W., Diao, W., Xie, X., Wang, Z., Zhang, J., Shen, Y., Long, J. |
None |
| S-Adenosyl-S-carboxymethyl-L-homocysteine: a novel cofactor found in the putative tRNA-modifying enzyme CmoA. |
Byrne, R.T., Whelan, F., Aller, P., Bird, L.E., Dowle, A., Lobley, C.M., Reddivari, Y., Nettleship, J.E., Owens, R.J., Antson, A.A., Waterman, D.G. |
None |
| Crystal structure of human cytoplasmic tRNAHis-specific 5'-monomethylphosphate capping enzyme. |
Liu, Y., Martinez, A., Yamashita, S., Tomita, K. |
None |
| The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity. |
Wolfe, A.D., Li, S., Goedderz, C., Chen, X.S. |
None |
| Crystal structure of YecO from Haemophilus influenzae (HI0319) reveals a methyltransferase fold and a bound S-adenosylhomocysteine. |
Lim, K., Zhang, H., Tempczyk, A., Bonander, N., Toedt, J., Howard, A., Eisenstein, E., Herzberg, O. |
None |
| From bacterial to human dihydrouridine synthase: automated structure determination. |
Whelan, F., Jenkins, H.T., Griffiths, S.C., Byrne, R.T., Dodson, E.J., Antson, A.A. |
None |
| Structural basis for site-specific ribose methylation by box C/D RNA protein complexes. |
Lin, J., Lai, S., Jia, R., Xu, A., Zhang, L., Lu, J., Ye, K. |
None |
| Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor. |
Doxtader, K.A., Wang, P., Scarborough, A.M., Seo, D., Conrad, N.K., Nam, Y. |
None |
| Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. |
Pastore, C., Topalidou, I., Forouhar, F., Yan, A.C., Levy, M., Hunt, J.F. |
None |
| METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes. |
Moroz-Omori, E.V., Huang, D., Kumar Bedi, R., Cheriyamkunnel, S.J., Bochenkova, E., Dolbois, A., Rzeczkowski, M.D., Li, Y., Wiedmer, L., Caflisch, A. |
None |
| Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site. |
Das, K., Acton, T., Chiang, Y., Shih, L., Arnold, E., Montelione, G.T. |
None |
| Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases. |
Pulicherla, N., Pogorzala, L.A., Xu, Z., O Farrell, H.C., Musayev, F.N., Scarsdale, J.N., Sia, E.A., Culver, G.M., Rife, J.P. |
None |
| The structures of non-CG-repeat Z-DNAs co-crystallized with the Z-DNA-binding domain, hZ{alpha}ADAR1 |
Ha, S.C., Choi, J., Hwang, H.Y., Rich, A., Kim, Y.G., Kim, K.K. |
None |
| Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions. |
Cory, S.A., Van Vranken, J.G., Brignole, E.J., Patra, S., Winge, D.R., Drennan, C.L., Rutter, J., Barondeau, D.P. |
None |
| Structural basis for nucleotide recognition by the ectoenzyme CD203c. |
Gorelik, A., Randriamihaja, A., Illes, K., Nagar, B. |
None |
| Conformational Stability Adaptation of a Double-Stranded RNA-Binding Domain to Transfer RNA Ligand. |
Bou-Nader, C., Pecqueur, L., Barraud, P., Fontecave, M., Tisne, C., Sacquin-Mora, S., Hamdane, D. |
None |
| Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis. |
Thomas, S.R., Keller, C.A., Szyk, A., Cannon, J.R., Laronde-Leblanc, N.A. |
None |
| Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase. |
Kim, J., Malashkevich, V., Roday, S., Lisbin, M., Schramm, V.L., Almo, S.C. |
None |
| Structural and functional characterization of Rv2966c protein reveals an RsmD-like methyltransferase from Mycobacterium tuberculosis and the role of its N-terminal domain in target recognition |
Kumar, A., Saigal, K., Malhotra, K., Sinha, K.M., Taneja, B. |
None |
| Structure and function of the bacterial decapping enzyme NudC. |
Hofer, K., Li, S., Abele, F., Frindert, J., Schlotthauer, J., Grawenhoff, J., Du, J., Patel, D.J., Jaschke, A. |
None |
| Crystal and solution structures of methyltransferase RsmH provide basis for methylation of C1402 in 16S rRNA. |
Wei, Y., Zhang, H., Gao, Z.Q., Wang, W.J., Shtykova, E.V., Xu, J.H., Liu, Q.S., Dong, Y.H. |
None |
| Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity |
Gu, M., Fabrega, C., Liu, S.W., Liu, H., Kiledjian, M., Lima, C.D. |
None |
| Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. |
Pastore, C., Topalidou, I., Forouhar, F., Yan, A.C., Levy, M., Hunt, J.F. |
None |
| Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases. |
Ha, S.C., Lowenhaupt, K., Rich, A., Kim, Y.G., Kim, K.K. |
None |
| Crystal Structure of the DNA Cytosine Deaminase APOBEC3F: The Catalytically Active and HIV-1 Vif-Binding Domain. |
Bohn, M.F., Shandilya, S.M., Albin, J.S., Kouno, T., Anderson, B.D., McDougle, R.M., Carpenter, M.A., Rathore, A., Evans, L., Davis, A.N., Zhang, J., Lu, Y., Somasundaran, M., Matsuo, H., Harris, R.S., Schiffer, C.A. |
None |
| Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis. |
Thomas, S.R., Keller, C.A., Szyk, A., Cannon, J.R., Laronde-Leblanc, N.A. |
None |
| Substrate tRNA recognition mechanism of a multisite-specific tRNA methyltransferase, Aquifex aeolicus Trm1, based on the X-ray crystal structure |
Awai, T., Ochi, A., Ihsanawati, Sengoku, T., Hirata, A., Bessho, Y., Yokoyama, S., Hori, H. |
None |
| Box C/D guide RNAs recognize a maximum of 10 nt of substrates |
Yang, Z., Lin, J., Ye, K. |
None |
| Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development. |
Mendel, M., Chen, K.M., Homolka, D., Gos, P., Pandey, R.R., McCarthy, A.A., Pillai, R.S. |
None |
| Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA |
Liang, B., Zhou, J., Kahen, E., Terns, R.M., Terns, M.P., Li, H. |
None |
| Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes |
Sunita, S., Tkaczuk, K.L., Purta, E., Kasprzak, J.M., Douthwaite, S., Bujnicki, J.M., Sivaraman, J. |
None |
| Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases. |
Husain, N., Tkaczuk, K.L., Tulsidas, S.R., Kaminska, K.H., Cubrilo, S., Maravic-Vlahovicek, G., Bujnicki, J.M., Sivaraman, J. |
None |
| Binding of adenosine-based ligands to the MjDim1 rRNA methyltransferase: implications for reaction mechanism and drug design. |
O'Farrell, H.C., Musayev, F.N., Scarsdale, J.N., Rife, J.P. |
None |
| Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. |
Yan, L., Yang, Y., Li, M., Zhang, Y., Zheng, L., Ge, J., Huang, Y.C., Liu, Z., Wang, T., Gao, S., Zhang, R., Huang, Y.Y., Guddat, L.W., Gao, Y., Rao, Z., Lou, Z. |
None |
| Pyruvate formate lyase is structurally homologous to type I ribonucleotide reductase. |
Leppanen, V.M., Merckel, M.C., Ollis, D.L., Wong, K.K., Kozarich, J.W., Goldman, A. |
None |
| The APOBEC3C crystal structure and the interface for HIV-1 Vif binding. |
Kitamura, S., Ode, H., Nakashima, M., Imahashi, M., Naganawa, Y., Kurosawa, T., Yokomaku, Y., Yamane, T., Watanabe, N., Suzuki, A., Sugiura, W., Iwatani, Y. |
None |
| Snapshots of dynamics in synthesizing N(6)-isopentenyladenosine at the tRNA anticodon |
Chimnaronk, S., Forouhar, F., Sakai, J., Yao, M., Tron, C.M., Atta, M., Fontecave, M., Hunt, J.F., Tanaka, I. |
None |
| Structural Basis for the Specificity of Human Nudt16 and its Regulation by Inosine Monophosphate. |
Tresaugues, L., Lundback, T., Welin, M., Flodin, S., Nyman, T., Silvander, C., Graslund, S., Nordlund, P. |
None |
| AID Recognizes Structured DNA for Class Switch Recombination. |
Qiao, Q., Wang, L., Meng, F.L., Hwang, J.K., Alt, F.W., Wu, H. |
None |
| Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs. |
Wu, H., Li, L., Chen, K.M., Homolka, D., Gos, P., Fleury-Olela, F., McCarthy, A.A., Pillai, R.S. |
None |
| Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. |
Demirci, H., Larsen, L.H., Hansen, T., Rasmussen, A., Cadambi, A., Gregory, S.T., Kirpekar, F., Jogl, G. |
None |
| Crystal structure of Rv2118c: an AdoMet-dependent methyltransferase from Mycobacterium tuberculosis H37Rv. |
Gupta, A., Kumar, P.H., Dineshkumar, T.K., Varshney, U., Subramanya, H.S. |
None |
| Control of Substrate Specificity by a Single Active Site Residue of the KsgA Methyltransferase. |
O'Farrell, H.C., Musayev, F.N., Scarsdale, J.N., Rife, J.P. |
None |
| Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B. |
Shi, K., Demir, O., Carpenter, M.A., Wagner, J., Kurahashi, K., Harris, R.S., Amaro, R.E., Aihara, H. |
None |
| Unveiling structural and functional divergences of bacterial tRNA dihydrouridine synthases: perspectives on the evolution scenario. |
Bou-Nader, C., Montemont, H., Guerineau, V., Jean-Jean, O., Bregeon, D., Hamdane, D. |
None |
| Crystal structure of KsgA, a universally conserved rRNA adenine dimethyltransferase in Escherichia coli |
O'Farrell, H.C., Scarsdale, J.N., Rife, J.P. |
None |
| Structural determinants of HIV-1 Vif susceptibility and DNA binding in APOBEC3F. |
Siu, K.K., Sultana, A., Azimi, F.C., Lee, J.E. |
None |
| Crystal structure of the apo forms of psi 55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft. |
Chaudhuri, B.N., Chan, S., Perry, L.J., Yeates, T.O. |
None |
| Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5. |
Goto-Ito, S., Ito, T., Ishii, R., Muto, Y., Bessho, Y., Yokoyama, S. |
None |
| Solution structure of Kti11p from Saccharomyces cerevisiae reveals a novel zinc-binding module. |
Sun, J., Zhang, J., Wu, F., Xu, C., Li, S., Zhao, W., Wu, Z., Wu, J., Zhou, C.Z., Shi, Y. |
None |
| RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon |
Chimnaronk, S., Suzuki, T., Manita, T., Ikeuchi, Y., Yao, M., Suzuki, T., Tanaka, I. |
None |
| Structure of dihydrouridine synthase C (DusC) from Escherichia coli |
Chen, M., Yu, J., Tanaka, Y., Tanaka, M., Tanaka, I., Yao, M. |
None |
| Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA. |
Yan, X., Lan, W., Wang, C., Cao, C. |
None |
| Structural Basis for Sulfur Relay to RNA Mediated by Heterohexameric TusBCD Complex |
Numata, T., Fukai, S., Ikeuchi, Y., Suzuki, T., Nureki, O. |
None |
| CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid |
Lu, J., Cao, Q., Hughes, M.P., Sawaya, M.R., Boyer, D.R., Cascio, D., Eisenberg, D.S. |
Jan. 1, 2020 |
| Structural and catalytic roles of the human 18SrRNA methyltransferases DIMT1 in ribosome assembly and translation |
Shen, H., Stoute, J., Liu, K.F |
Jan. 1, 2020 |
| Molecular basis of tRNA recognition by the Elongator complex. |
Dauden, M.I., Jaciuk, M., Weis, F., Lin, T.Y., Kleindienst, C., Abbassi, N.E.H., Khatter, H., Krutyholowa, R., Breunig, K.D., Kosinski, J., Muller, C.W., Glatt, S. |
Jan. 1, 2019 |
| Characterization of novel human Intragenic Antimicrobial Peptides, incorporation and release studies from ureasil-polyether hybrid matrix |
Mariano, G.H., Gomes de Sa, L.G., Carmo da Silva, E.M., Santos, M.A., Cardozo Fh, J., Lira, B.O.V., Barbosa, E.A., Araujo, A.R., Leite, J.R.S.A., Ramada, M.H.S., Bloch Jr., C., Oliveira, A.L., Chaker, J.A., Brand, G.D. |
Jan. 1, 2020 |
| Molecular architecture of the human U4/U6.U5 tri-snRNP. |
Agafonov, D.E., Kastner, B., Dybkov, O., Hofele, R.V., Liu, W.T., Urlaub, H., Luhrmann, R., Stark, H. |
Jan. 1, 2016 |
| Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation |
Bertram, K., Agafonov, D.E., Dybkov, O., Haselbach, D., Leelaram, M.N., Will, C.L., Urlaub, H., Kastner, B., Luhrmann, R., Stark, H. |
Jan. 1, 2017 |
| Structures of the human pre-catalytic spliceosome and its precursor spliceosome. |
Zhan, X., Yan, C., Zhang, X., Lei, J., Shi, Y. |
Jan. 1, 2018 |
| Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes. |
Kater, L., Thoms, M., Barrio-Garcia, C., Cheng, J., Ismail, S., Ahmed, Y.L., Bange, G., Kressler, D., Berninghausen, O., Sinning, I., Hurt, E., Beckmann, R. |
Jan. 1, 2017 |
| RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function |
Tim D. Werry , Richard Loiacono, Patrick M. Sexton, Arthur Christopoulos |
June 1, 2008 |
| Editing modifies the GABAA receptor subunit α3 |
Johan Ohlson, Jakob Skou Pedersen, David Haussler, and Marie Öhman1 |
May 1, 2007 |
| The expansion of Inosine at the wobble position of tRNAs, and its role in the evolution of proteomes |
Àlbert Rafels-Ybern, Adrian Gabriel Torres, Noelia Camacho, Andrea Herencia-Ropero , Helena Roura Frigolé, Thomas F. Wulff, Marina Raboteg, Albert Bordons , Xavier Grau-Bove, Iñaki Ruiz-Trillo , Lluís Ribas de Pouplana |
April 1, 2019 |
| A limited number of pseudouridine residues in the human atac spliceosomal UsnRNAs as compared to human major spliceosomal UsnRNAs |
S Massenet, C Branlant |
Jan. 1, 1999 |
| Interaction mode between catalytic and regulatory subunits in glucosidase II involved in ER glycoprotein quality control |
Satoh, T., Toshimori, T., Noda, M., Uchiyama, S., Kato, K. |
Jan. 1, 2016 |
| Archtecture of the yeast small subunit processome |
Chaker-Margot, M., Barandun, J., Hunziker, M., Klinge, S. |
Jan. 1, 2017 |
| The complete structure of small.subunit processome |
Barandun, J., Chaker-Margot, M., Hunziker, M., Molloy, K.R., Chait, B.T., Klinge, S. |
None |
| Molecular architecture of the 90S small subunit pre-ribosome |
Sun, Q., Zhu, X., Qi, J., An, W., Lan, P., Tan, D., Chen, R., Wang, B., Zheng, S., Zhang, C., Chen, X., Zhang, W., Chen, J., Dong, M.Q., Ye, K. |
None |
| Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states. |
Du, Y., An, W., Zhu, X., Sun, Q., Qi, J., Ye, K. |
Jan. 1, 2020 |
| 90 S pre-ribosome transformation into the primordial 40 S subunit. |
Cheng, J., Lau, B., La Venuta, G., Ameismeier, M., Berninghausen, O., Hurt, E., Beckmann, R. |
Jan. 1, 2020 |
| Conformational switches control early maturation of the eukaryotic small ribosomal subunit. |
Hunziker, M., Barandun, J., Buzovetsky, O., Steckler, C., Molina, H., Klinge, S. |
Jan. 1, 2019 |
| Visualizing late states of human 40S ribosomal subunit maturation. |
Ameismeier, M., Cheng, J., Berninghausen, O., Beckmann, R. |
Jan. 1, 2018 |
| A distinct assembly pathway of the human 39S late pre-mitoribosome |
Cheng, J., Berninghausen, O., Beckmann, R. |
Jan. 1, 2021 |
| Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination |
Riccardo Pecori , Salvatore Di Giorgio, J Paulo Lorenzo, F Nina Papavasiliou |
March 7, 2022 |
| Taurine-containing uridine modifications in tRNA anticodons are required to decipher non-universal genetic codes in ascidian mitochondria |
Takeo Suzuki , Kenjyo Miyauchi , Tsutomu Suzuki , Shin-Ichi Yokobori, Naoki Shigi , Akiko Kondow , Nono Takeuchi , Akihiko Yamagishi, Kimitsuna Watanabe |
Oct. 14, 2011 |
| Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing |
P P Lau, H J Zhu, M Nakamuta, L Chan |
Jan. 17, 1997 |
| The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase |
N Navaratnam , J R Morrison, S Bhattacharya, D Patel, T Funahashi, F Giannoni, B B Teng, N O Davidson, J Scott |
Oct. 5, 1993 |
| The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas |
Giulia Saraconi, Francesco Severi, Cesare Sala, Giorgio Mattiuz, and Silvestro G Conticello |
None |
| Crystal structure of an H/ACA box ribonucleoprotein particle |
Li, L., Ye, K. |
Jan. 1, 2006 |
| Substrate RNA positioning in the archaeal H/ACA ribonucleoprotein complex |
Liang, B., Xue, S., Terns, R.M., Terns, M.P., Li, H. |
Jan. 1, 2007 |
| Glycosidic bond conformation preference plays a pivotal role in catalysis of RNA pseudouridylation: a combined simulation and structural study. |
Zhou, J., Lv, C., Liang, B., Chen, M., Yang, W., Li, H. |
Jan. 1, 2010 |
| Functional and Structural Impact of Target Uridine Substitutions on the H/ACA Ribonucleoprotein Particle Pseudouridine Synthase |
Zhou, J., Liang, B., Li, H. |
Jan. 1, 2010 |
| Structural and functional evidence of high specificity of Cbf5 for ACA trinucleotide. |
Zhou, J., Liang, B., Li, H. |
Jan. 1, 2011 |
| A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. |
C X Chen, D S Cho, Q Wang, F Lai, K C Carter, and K Nishikura |
May 1, 2000 |
| Functions and Regulation of RNA Editing by ADAR Deaminases |
Kazuko Nishikura |
Jan. 1, 2010 |
| Chapter 21 - Aberrant AID Expression by Pathogen Infection |
Atsushi Takai, Hiroyuki Marusawa, Tsutomu Chiba |
Jan. 1, 2015 |
| Nucleolar maturation of the human small subunit processome. |
Singh, S., Vanden Broeck, A., Miller, L., Chaker-Margot, M., Klinge, S. |
Sept. 1, 2021 |
| 7-Methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (dcpS) enzymes and potently inhibits their activity. |
Wypijewska A., Bojarska E., Lukaszewicz M., Stepinski J., Jemielity J., Davis R.E., Darzynkiewicz E. |
Oct. 9, 2012 |
| KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. |
Metzger, E., Wang, S., Urban, S., Willmann, D., Schmidt, A., Offermann, A., Allen, A., Sum, M., Obier, N., Cottard, F., Ulferts, S., Preca, B.T., Hermann, B., Maurer, J., Greschik, H., Hornung, V., Einsle, O., Perner, S., Imhof, A., Jung, M., Schule, R. |
None |
| Structural characterization of glycinamide-RNase-transformylase T fromMycobacterium tuberculosis. |
Chen, C., Liu, Z., Liu, L., Wang, J., Jin, Q. |
Jan. 1, 2020 |
| Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase. |
Li, W., Shi, Y., Zhang, T., Ye, J., Ding, J. |
Jan. 1, 2019 |
| THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates. |
Yang W.Q., Xiong Q.P., Ge J.Y., Li H., Zhu W.Y., Nie Y., Lin X., Lv D., Li J., Lin H., Liu R.J. |
Jan. 1, 2021 |
| Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima |
Dan Yu, Gundeep Kaur, Robert M Blumenthal, Xing Zhang, Xiaodong Cheng |
Jan. 1, 2021 |
| The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation |
Caraline Sepich-Poore, Zhong Zheng, Emily Schmitt, Kailong Wen, Zijie Scott Zhang, Xiao-Long Cui, Qing Dai, Allen C Zhu, Linda Zhang, Arantxa Sanchez Castillo, Haiyan Tan, Junmin Peng , Xiaoxi Zhuang, Chuan He, Sigrid Nachtergaele |
March 1, 2022 |
| Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine. |
Johannsson, S., Neumann, P., Wulf, A., Welp, L.M., Gerber, H.D., Krull, M., Diederichsen, U., Urlaub, H., Ficner, R |
None |
| Target recognition, RNA methylation activity and transcriptional regulation of the Dictyostelium discoideum Dnmt2-homologue (DnmA) |
Sara Müller, Indra M. Windhof, Vladimir Maximov, Tomasz Jurkowski, Albert Jeltsch, Konrad U. Förstner, Cynthia M. Sharma, Ralph Gräf, and Wolfgang Nellen |
Oct. 1, 2013 |
| Structural insights into the catalytic mechanism of Escherichia coli selenophosphate synthetase. |
Noinaj, N., Wattanasak, R., Lee, D.Y., Wally, J.L., Piszczek, G., Chock, P.B., Stadtman, T.C., Buchanan, S.K. |
Jan. 1, 2010 |
| Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis. |
Kater, L., Mitterer, V., Thoms, M., Cheng, J., Berninghausen, O., Beckmann, R., Hurt, E. |
Jan. 1, 2020 |
| Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors. |
Poll, G., Pilsl, M., Griesenbeck, J., Tschochner, H., Milkereit, P. |
Jan. 1, 2021 |
| Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition. |
Hirata, A., Okada, K., Yoshii, K., Shiraishi, H., Saijo, S., Yonezawa, K., Shimizu, N., Hori, H. |
Jan. 1, 2019 |
| Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae. |
Wang, M., Zhu, Y., Wang, C., Fan, X., Jiang, X., Ebrahimi, M., Qiao, Z., Niu, L., Teng, M., Li, X. |
None |
| Structural insights into the function of 23S rRNA methyltransferase RlmG (m2G1835) from Escherichia coli |
Zhang, H., Gao, Z.Q., Wei, Y., Wang, W.J., Liu, G.F., Shtykova, E.V., Xu, J.H., Dong, Y.H. |
Jan. 1, 2012 |
| Structural characterization of B. subtilis m1A22 tRNA methyltransferase TrmK: insights into tRNA recognition |
Degut, C., Roovers, M., Barraud, P., Brachet, F., Feller, A., Larue, V., Al Refaii, A., Caillet, J., Droogmans, L., Tisne, C. |
Jan. 1, 2019 |
| Crystal structure of the ancient, Fe-S scaffold IscA reveals a novel protein fold. |
Bilder, P.W., Ding, H., Newcomer, M.E. |
Jan. 1, 2004 |
| Conformational proofreading of distant 40S ribosomal subunit maturation events by a long-range communication mechanism. |
Mitterer, V., Shayan, R., Ferreira-Cerca, S., Murat, G., Enne, T., Rinaldi, D., Weigl, S., Omanic, H., Gleizes, P.E., Kressler, D., Plisson-Chastang, C., Pertschy, B. |
Jan. 1, 2019 |
| rystal structure of the yeast heterodimeric ADAT2/3 deaminase. |
Liu, X., Chen, R., Sun, Y., Chen, R., Zhou, J., Tian, Q., Tao, X., Zhang, Z., Luo, G.Z., Xie, W. |
Jan. 1, 2020 |
| Structural Insights into the Methylation of C1402 in 16S rRNA by Methyltransferase RsmI |
Zhao, M., Zhang, H., Liu, G., Wang, L., Wang, J., Gao, Z., Dong, Y., Zhang, L., Gong, Y. |
Jan. 1, 2016 |
| Crystal Structure of Rlmm, the 2'O-Ribose Methyltransferase for C2498 of Escherichia Coli 23S Rrna |
Punekar, A.S., Shepherd, T.R., Liljeruhm, J., Forster, A.C., Selmer, M. |
Jan. 1, 2012 |
| NMR-based Structural Analysis of Threonylcarbamoyl-AMP Synthase and Its Substrate Interactions. |
Harris, K.A., Bobay, B.G., Sarachan, K.L., Sims, A.F., Bilbille, Y., Deutsch, C., Iwata-Reuyl, D., Agris, P.F. |
Jan. 1, 2015 |
| Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis |
Wan, L.C., Pillon, M.C., Thevakumaran, N., Sun, Y., Chakrabartty, A., Guarne, A., Kurinov, I., Durocher, D., Sicheri, F. |
Jan. 1, 2016 |
| Human cells have a limited set of tRNA anticodon loop substrates of the tRNA isopentenyltransferase TRIT1 tumor suppressor |
Tek N Lamichhane , Sandy Mattijssen, Richard J Maraia |
None |
| Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. |
Wan, L.C., Mao, D.Y., Neculai, D., Strecker, J., Chiovitti, D., Kurinov, I., Poda, G., Thevakumaran, N., Yuan, F., Szilard, R.K., Lissina, E., Nislow, C., Caudy, A.A., Durocher, D., Sicheri, F. |
Jan. 1, 2013 |
| The Era GTPase recognizes the GAUCACCUCC sequence and binds helix 45 near the 3' end of 16S rRNA. |
Tu, C., Zhou, X., Tarasov, S.G., Tropea, J.E., Austin, B.P., Waugh, D.S., Court, D.L., Ji, X. |
Jan. 1, 2011 |
| Deciphering Determinants in Ribosomal Methyltransferases That Confer Antimicrobial Resistance |
Bhujbalrao, R., Anand, R. |
Jan. 1, 2019 |
| Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methyltransferases. |
Singh, J., Raina, R., Vinothkumar, K.R., Anand, R. |
Jan. 1, 2022 |
| The ATP-mediated formation of the YgjD-YeaZ-YjeE complex is required for the biosynthesis of tRNA t6A in Escherichia coli |
Zhang, W., Collinet, B., Perrochia, L., Durand, D., van Tilbeurgh, H. |
None |
| Structure of a reaction intermediate mimic in t6A biosynthesis bound in the active site of the TsaBD heterodimer from Escherichia coli. |
Kopina, B.J., Missoury, S., Collinet, B., Fulton, M.G., Cirio, C., van Tilbeurgh, H., Lauhon, C.T. |
None |
| Expanding the Kinome World: A New Protein Kinase Family Widely Conserved in Bacteria |
Nguyen, H.A., El Khoury, T., Guiral, S., Laaberki, M.H., Candusso, M.P., Galisson, F., Foucher, A.E., Kesraoui, S., Ballut, L., Vallet, S., Orelle, C., Zucchini, L., Martin, J., Page, A., Attieh, J., Aghajari, N., Grangeasse, C., Jault, J.M. |
None |
| Protection of the Queuosine Biosynthesis Enzyme QueF from Irreversible Oxidation by a Conserved Intramolecular Disulfide |
Mohammad, A., Bon Ramos, A., Lee, B.W., Cohen, S.W., Kiani, M.K., Iwata-Reuyl, D., Stec, B., Swairjo, M.A. |
Jan. 1, 2017 |
| The m1A58 modification in eubacterial tRNA: An overview of tRNA recognition and mechanism of catalysis by Trm |
Degut, C., Ponchon, L., Folly-Klan, M., Barraud, P., Tisne, C. |
Jan. 1, 2016 |
| Structural insights into actin filament recognition by commonly used cellular actin markers |
Kumari, A., Kesarwani, S., Javoor, M.G., Vinothkumar, K.R., Sirajuddin, M. |
None |
| Structure of the Lifeact-F-actin complex |
Belyy, A., Merino, F., Sitsel, O., Raunser, S. |
None |
| Structural model of the M7G46 Methyltransferase TrmB in complex with tRNA |
Blersch, K.F., Burchert, J.P., August, S.C., Welp, L., Neumann, P., Koster, S., Urlaub, H., Ficner, R. |
Jan. 1, 2021 |
| Crystal structure of the Tum1 protein from the yeast Saccharomyces cerevisiae. |
Qiu, R., Wang, F., Liu, M., Lou, T., Ji, C. |
Jan. 1, 2021 |
| The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins |
Schmitz, J., Chowdhury, M.M., Hanzelmann, P., Nimtz, M., Lee, E.Y., Schindelin, H., Leimkuhler, S. |
Jan. 1, 2008 |
| Structural basis of dcp2 recognition and activation by dcp1 |
She, M., Decker, C.J., Svergun, D.I., Round, A., Chen, N., Muhlrad, D., Parker, R., Song, H. |
Jan. 1, 2008 |
| The Structural Basis of Edc3- and Scd6-Mediated Activation of the Dcp1:Dcp2 Mrna Decapping Complex |
Fromm, S.A., Truffault, V., Kamenz, J., Braun, J.E., Hoffmann, N.A., Izaurralde, E., Sprangers, R. |
None |
| Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation. |
Valkov, E., Muthukumar, S., Chang, C.T., Jonas, S., Weichenrieder, O., Izaurralde, E. |
None |
| Structural basis of mRNA-cap recognition by Dcp1-Dcp2. |
Mugridge, J.S., Ziemniak, M., Jemielity, J., Gross, J.D. |
None |
| Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme. |
Wurm, J.P., Holdermann, I., Overbeck, J.H., Mayer, P.H.O., Sprangers, R. |
None |
| DcpS as a therapeutic target for spinal muscular atrophy. |
Singh, J., Salcius, M., Liu, S.W., Staker, B.L., Mishra, R., Thurmond, J., Michaud, G., Mattoon, D.R., Printen, J., Christensen, J., Bjornsson, J.M., Pollok, B.A., Kiledjian, M., Stewart, L., Jarecki, J., Gurney, M.E. |
None |
| Structures and mechanisms of tRNA methylation by METTL1-WDR4. |
Ruiz-Arroyo, V.M., Raj, R., Babu, K., Onolbaatar, O., Roberts, P.H., Nam, Y. |
None |
| Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. |
Li, J., Wang, L., Hahn, Q., Nowak, R.P., Viennet, T., Orellana, E.A., Roy Burman, S.S., Yue, H., Hunkeler, M., Fontana, P., Wu, H., Arthanari, H., Fischer, E.S., Gregory, R.I. |
None |
| Epigenetic control of rDNA loci in response to intracellular energy status |
Murayama, A., Ohmori, K., Fujimura, A., Minami, H., Yasuzawa-Tanaka, K., Kuroda, T., Oie, S., Daitoku, H., Okuwaki, M., Nagata, K., Fukamizu, A., Kimura, K., Shimizu, T., Yanagisawa, J. |
None |
| Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes. |
Kaur, S., Tam, N.Y., McDonough, M.A., Schofield, C.J., Aik, W.S. |
None |
| Crystal structure of the RNA demethylase ALKBH5 from zebrafish. |
Chen, W., Zhang, L., Zheng, G., Fu, Y., Ji, Q., Liu, F., Chen, H., He, C. |
None |
| Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. |
|
None |
| Switching Demethylation Activities between AlkB Family RNA/DNA Demethylases through Exchange of Active-Site Residues. |
Zhu, C., Yi, C. |
None |
| Structural basis of RNA processing by human mitochondrial RNase P |
Bhatta, A., Dienemann, C., Cramer, P., Hillen, H.S. |
None |
| A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor ofN6-methyladenosine demethylase FTO. |
Toh, J.D.W., Sun, L., Lau, L.Z.M., Tan, J., Low, J.J.A., Tang, C.W.Q., Cheong, E.J.Y., Tan, M.J.H., Chen, Y., Hong, W., Gao, Y.G., Woon, E.C.Y. |
None |
| Structural basis for inhibition of the fat mass and obesity associated protein (FTO) |
Aik, W.S., Demetriades, M., Hamdan, M.K.K., Bagg, E.A.L., Yeoh, K.K., Lejeune, C., Zhang, Z., McDonough, M.A., Schofield, C.J. |
None |
| Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors |
Shishodia, S., Demetriades, M., Zhang, D., Tam, N.Y., Maheswaran, P., Clunie-O'Connor, C., Tumber, A., Leung, I.K.H., Ng, Y.M., Leissing, T.M., El-Sagheer, A.H., Salah, E., Brown, T., Aik, W.S., McDonough, M.A., Schofield, C.J. |
None |
| Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein |
Wang, T., Hong, T., Huang, Y., Su, H., Wu, F., Chen, Y., Wei, L., Huang, W., Hua, X., Xia, Y., Xu, J., Gan, J., Yuan, B., Feng, Y., Zhang, X., Yang, C.G., Zhou, X. |
None |
| Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates |
Zhang, X., Wei, L.H., Wang, Y., Xiao, Y., Liu, J., Zhang, W., Yan, N., Amu, G., Tang, X., Zhang, L., Jia, G. |
None |
| Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1 |
Peng, S., Xiao, W., Ju, D., Sun, B., Hou, N., Liu, Q., Wang, Y., Zhao, H., Gao, C., Zhang, S., Cao, R., Li, P., Huang, H., Ma, Y., Wang, Y., Lai, W., Ma, Z., Zhang, W., Huang, S., Wang, H., Zhang, Z., Zhao, L., Cai, T., Zhao, Y.L., Wang, F., Nie, Y., Zhi, G., Yang, Y.G., Zhang, E.E., Huang, N. |
None |
| Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. |
Liu, Y., Liang, G., Xu, H., Dong, W., Dong, Z., Qiu, Z., Zhang, Z., Li, F., Huang, Y., Li, Y., Wu, J., Yin, S., Zhang, Y., Guo, P., Liu, J., Xi, J.J., Jiang, P., Han, D., Yang, C.G., Xu, M.M. |
None |
| Structure-Activity Relationships and Antileukemia Effects of the Tricyclic Benzoic Acid FTO Inhibitors |
Liu, Z., Duan, Z., Zhang, D., Xiao, P., Zhang, T., Xu, H., Wang, C.H., Rao, G.W., Gan, J., Huang, Y., Yang, C.G., Dong, Z. |
None |
| 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. |
Dolbois, A., Bedi, R.K., Bochenkova, E., Muller, A., Moroz-Omori, E.V., Huang, D., Caflisch, A. |
None |
| Crystal structures of the bifunctional tRNA methyltransferase Trm5a |
Wang, C., Jia, Q., Chen, R., Wei, Y., Li, J., Ma, J., Xie, W. |
None |
| Structural insight into the methyltransfer mechanism of the bifunctional Trm5 |
Wang, C., Jia, Q., Zeng, J., Chen, R., Xie, W. |
None |
| The crystal structure of the Pyrococcus abyssi mono-functional methyltransferase PaTrm5b |
Wu, J., Jia, Q., Wu, S., Zeng, H., Sun, Y., Wang, C., Ge, R., Xie, W. |
None |
| Artificial intelligence-assisted cryoEM structure of Bfr2-Lcp5 complex observed in the yeast small subunit processome |
Zhao, Y., Rai, J., Xu, C., He, H., Li, H. |
None |
| Structural basis for late maturation steps of the human mitoribosomal large subunit. |
Cipullo, M., Gese, G.V., Khawaja, A., Hallberg, B.M., Rorbach, J. |
None |
| Stepwise maturation of the peptidyl transferase region of human mitoribosomes. |
Lenarcic, T., Jaskolowski, M., Leibundgut, M., Scaiola, A., Schonhut, T., Saurer, M., Lee, R.G., Rackham, O., Filipovska, A., Ban, N. |
None |
| Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling. |
Hillen, H.S., Lavdovskaia, E., Nadler, F., Hanitsch, E., Linden, A., Bohnsack, K.E., Urlaub, H., Richter-Dennerlein, R. |
None |
| Visualizing formation of the active site in the mitochondrial ribosome. |
Chandrasekaran, V., Desai, N., Burton, N.O., Yang, H., Price, J., Miska, E.A., Ramakrishnan, V. |
None |
| Structural and functional insights into human tRNA guanine transgylcosylase |
Sievers, K., Welp, L., Urlaub, H., Ficner, R. |
None |
| Crystal structure of human METTL6, the m3C methyltransferase |
Chen, R., Zhou, J., Liu, L., Mao, X.L., Zhou, X., Xie, W. |
None |
| Structural basis for METTL6-mediated m3C RNA methylation. |
Li, S., Zhou, H., Liao, S., Wang, X., Zhu, Z., Zhang, J., Xu, C. |
None |
| Cryo-EM structures of human m6A writer complexes. |
Su, S., Li, S., Deng, T., Gao, M., Yin, Y., Wu, B., Peng, C., Liu, J., Ma, J., Zhang, K. |
None |
| AI-empowered integrative structural characterization of m 6 A methyltransferase complex. |
Yan, X., Pei, K., Guan, Z., Liu, F., Yan, J., Jin, X., Wang, Q., Hou, M., Tang, C., Yin, P. |
None |
| Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine. |
Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine. |
None |
| Fragment Ligands of the m 6 A-RNA Reader YTHDF2. |
Nai, F., Nachawati, R., Zalesak, F., Wang, X., Li, Y., Caflisch, A. |
None |
| Crystal structure of human YTHDC2 YTH domain. |
Ma, C., Liao, S., Zhu, Z. |
None |
| Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1 |
Baixing Wu 1, Shichen Su 1, Deepak P Patil 2, Hehua Liu 1 3, Jianhua Gan 3, Samie R Jaffrey 2, Jinbiao Ma 4 |
None |
| Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition. |
Liu, Y., Abula, A., Xiao, H., Guo, H., Li, T., Zheng, L., Chen, B., Nguyen, H.C., Ji, X. |
None |
| The Solution Structure and DNA-Binding Properties of the Cold-Shock Domain of the Human Y-Box Protein Yb-1. |
Kloks, C.P.A.M., Spronk, C.A.E.M., Lasonder, E., Hoffmann, A., Vuister, G.W., Grzesiek, S., Hilbers, C.W. |
None |
| Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. |
Yang, X.J., Zhu, H., Mu, S.R., Wei, W.J., Yuan, X., Wang, M., Liu, Y., Hui, J., Huang, Y. |
None |
| Structural basis of DNA binding to human YB-1 cold shock domain regulated by phosphorylation. |
Zhang, J., Fan, J.S., Li, S., Yang, Y., Sun, P., Zhu, Q., Wang, J., Jiang, B., Yang, D., Liu, M. |
None |
| Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. |
Matthews, M.M., Thomas, J.M., Zheng, Y., Tran, K., Phelps, K.J., Scott, A.I., Havel, J., Fisher, A.J., Beal, P.A. |
None |
| A Bump-Hole Approach for Directed RNA Editing. |
Monteleone, L.R., Matthews, M.M., Palumbo, C.M., Thomas, J.M., Zheng, Y., Chiang, Y., Fisher, A.J., Beal, P.A. |
None |
| Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition. |
Thuy-Boun, A.S., Thomas, J.M., Grajo, H.L., Palumbo, C.M., Park, S., Nguyen, L.T., Fisher, A.J., Beal, P.A. |
None |
| Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position. |
Doherty, E.E., Wilcox, X.E., van Sint Fiet, L., Kemmel, C., Turunen, J.J., Klein, B., Tantillo, D.J., Fisher, A.J., Beal, P.A. |
None |
| The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization. |
Bohn, M.F., Shandilya, S.M., Silvas, T.V., Nalivaika, E.A., Kouno, T., Kelch, B.A., Ryder, S.P., Kurt-Yilmaz, N., Somasundaran, M., Schiffer, C.A. |
None |
| Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity. |
Kouno, T., Silvas, T.V., Hilbert, B.J., Shandilya, S.M.D., Bohn, M.F., Kelch, B.A., Royer, W.E., Somasundaran, M., Kurt Yilmaz, N., Matsuo, H., Schiffer, C.A. |
None |
| Two different kinds of interaction modes of deaminase APOBEC3A with single-stranded DNA in solution detected by nuclear magnetic resonance. |
Liu, Y., Lan, W., Wang, C., Cao, C. |
None |
| Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia. |
Grummitt, C.G., Townsley, F.M., Johnson, C.M., Warren, A.J., Bycroft, M. |
None |
| Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7. |
Eichhorn, C.D., Yang, Y., Repeta, L., Feigon, J. |
None |
| Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP. |
Yang, Y., Liu, S., Egloff, S., Eichhorn, C.D., Hadjian, T., Zhen, J., Kiss, T., Zhou, Z.H., Feigon, J. |
None |
| Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7. |
Uchikawa, E., Natchiar, K.S., Han, X., Proux, F., Roblin, P., Zhang, E., Durand, A., Klaholz, B.P., Dock-Bregeon, A.C. |
None |
| Structure of human telomerase holoenzyme with bound telomeric DNA. |
Ghanim, G.E., Fountain, A.J., van Roon, A.M., Rangan, R., Das, R., Collins, K., Nguyen, T.H.D. |
None |
| Structure of active human telomerase with telomere shelterin protein TPP1. |
Liu, B., He, Y., Wang, Y., Song, H., Zhou, Z.H., Feigon, J. |
None |
| Zipper head mechanism of telomere synthesis by human telomerase. |
Wan, F., Ding, Y., Zhang, Y., Wu, Z., Li, S., Yang, L., Yan, X., Lan, P., Li, G., Wu, J., Lei, M. |
None |
| Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death. |
Margreiter, M.A., Witzenberger, M., Wasser, Y., Davydova, E., Janowski, R., Metz, J., Habib, P., Sahnoun, S.E.M., Sobisch, C., Poma, B., Palomino-Hernandez, O., Wagner, M., Carell, T., Jon Shah, N., Schulz, J.B., Niessing, D., Voigt, A., Rossetti, G. |
None |
| Mechanism of mitoribosomal small subunit biogenesis and preinitiation. |
Itoh, Y., Khawaja, A., Laptev, I., Cipullo, M., Atanassov, I., Sergiev, P., Rorbach, J., Amunts, A. |
None |
| Helicase of Type 2 Porcine Reproductive and Respiratory Syndrome Virus Strain HV Reveals a Unique Structure. |
Tang, C., Deng, Z., Li, X., Yang, M., Tian, Z., Chen, Z., Wang, G., Wu, W., Feng, W.H., Zhang, G., Chen, Z. |
None |
| Dodecamer Structure of Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein nsp10 |
Su, D., Lou, Z., Sun, F., Zhai, Y., Yang, H., Zhang, R., Joachimiak, A., Zhang, X.C., Bartlam, M., Rao, Z. |
None |
| Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex. |
Chen, Y., Su, C., Ke, M., Jin, X., Xu, L., Zhang, Z., Wu, A., Sun, Y., Yang, Z., Tien, P., Ahola, T., Liang, Y., Liu, X., Guo, D. |
None |
| Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex. |
Decroly, E., Debarnot, C., Ferron, F., Bouvet, M., Coutard, B., Imbert, I., Gluais, L., Papageorgiou, N., Sharff, A., Bricogne, G., Ortiz-Lombardia, M., Lescar, J., Canard, B. |
None |
| Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2. |
Rogstam, A., Nyblom, M., Christensen, S., Sele, C., Talibov, V.O., Lindvall, T., Rasmussen, A.A., Andre, I., Fisher, Z., Knecht, W., Kozielski, F. |
None |
| Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction |
Desogus, G., Todone, F., Brick, P., Onesti, S. |
None |
| The crystal structure of the lysyl-tRNA synthetase (LysU) from Escherichia coli |
Onesti, S., Miller, A.D., Brick, P. |
None |
| Structural insights into dpCoA-RNA decapping by NudC. |
Zhou, W., Guan, Z., Zhao, F., Ye, Y., Yang, F., Yin, P., Zhang, D. |
None |
| Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs. |
Zong, G., Shears, S.B., Wang, H. |
None |
| Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition. |
Shaban, N.M., Yan, R., Shi, K., Moraes, S.N., Cheng, A.Z., Carpenter, M.A., McLellan, J.S., Yu, Z., Harris, R.S. |
None |
| Eukaryotic stand-alone pseudouridine synthases – RNA modifying enzymes and emerging regulators of gene expression? |
Anne C. Rintala-Dempsey and Ute Kothe |
None |
| Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. |
Schubot, F.D., Chen, C.J., Rose, J.P., Dailey, T.A., Dailey, H.A., Wang, B.C. |
None |
| Structural comparison of yeast snoRNP and spliceosomal protein Snu13p with its homologs |
Oruganti, S., Zhang, Y., Li, H. |
None |
| The 3.8 angstrom structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis |
Wan, R., Yan, C., Bai, R., Wang, L., Huang, M., Wong, C.C., Shi, Y. |
None |
| Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control |
Bizarro, J., Charron, C., Boulon, S., Westman, B., Pradet-Balade, B., Vandermoere, F., Chagot, M.E., Hallais, M., Ahmad, Y., Leonhardt, H., Lamond, A., Manival, X., Branlant, C., Charpentier, B., Verheggen, C., Bertrand, E. |
None |
| Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution. |
Nguyen, T.H., Galej, W.P., Bai, X.C., Oubridge, C., Newman, A.J., Scheres, S.H., Nagai, K. |
None |
| Structure of a pre-catalytic spliceosome. |
Plaschka, C., Lin, P.C., Nagai, K. |
None |
| Architecture of the yeast small subunit processome. |
Chaker-Margot, M., Barandun, J., Hunziker, M., Klinge, S. |
None |
| The complete structure of the small-subunit processome. |
Barandun, J., Chaker-Margot, M., Hunziker, M., Molloy, K.R., Chait, B.T., Klinge, S. |
None |
| Molecular architecture of the 90S small subunit pre-ribosome. |
Sun, Q., Zhu, X., Qi, J., An, W., Lan, P., Tan, D., Chen, R., Wang, B., Zheng, S., Zhang, C., Chen, X., Zhang, W., Chen, J., Dong, M.Q., Ye, K. |
None |
| Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation |
Bai, R., Wan, R., Yan, C., Lei, J., Shi, Y. |
None |
| Biochemical and structural characterization of a thermostable Dps protein with His-type ferroxidase centers and outer metal-binding sites. |
Minato, T., Teramoto, T., Kakuta, Y., Ogo, S., Yoon, K.S. |
None |
| The Bacillus subtilis open reading frame ysgA encodes the SPOUT methyltransferase RlmP forming 2'- O-methylguanosine at position 2553 in the A-loop of 23S rRNA |
Martine Roovers , Geoffray Labar , Philippe Wolff , André Feller , Dany Van Elder , Romuald Soin , Cyril Gueydan , Véronique Kruys , Louis Droogmans |
None |
| Dissecting the roles of a strictly conserved tyrosine in substrate recognition and catalysis by pseudouridine 55 synthase |
Phannachet, K., Elias, Y., Huang, R.H. |
None |
| Conformational communication mediates the reset step in t6A biosynthesis. |
Luthra, A., Paranagama, N., Swinehart, W., Bayooz, S., Phan, P., Quach, V., Schiffer, J.M., Stec, B., Iwata-Reuyl, D., Swairjo, M.A. |
None |
| The structure of the TsaB/TsaD/TsaE complex reveals an unexpected mechanism for the bacterial t6A tRNA-modification. |
Missoury, S., Plancqueel, S., Li de la Sierra-Gallay, I., Zhang, W., Liger, D., Durand, D., Dammak, R., Collinet, B., van Tilbeurgh, H. |
None |
| The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase |
Jan Philip Wurm 1, Britta Meyer, Ute Bahr, Martin Held, Olga Frolow, Peter Kötter, Joachim W Engels, Alexander Heckel, Michael Karas, Karl-Dieter Entian, Jens Wöhnert |
None |
| Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans |
Britta Meyer 1, Jan Philip Wurm 2, Sunny Sharma 3, Carina Immer 2, Denys Pogoryelov 4, Peter Kötter 1, Denis L J Lafontaine 3, Jens Wöhnert 5, Karl-Dieter Entian |
None |
| The 18S ribosomal RNA m6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. |
Jessica Leismann # 1, Mariangela Spagnuolo # 1, Mihika Pradhan 1, Ludivine Wacheul 2, Minh Anh Vu 1, Michael Musheev 1, Pablo Mier 3, Miguel A Andrade-Navarro 3, Marc Graille 4, Christof Niehrs 1 5, Denis Lj Lafontaine 2, Jean-Yves Roignant 1 |
None |
| Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively |
Sunny Sharma 1, Jun Yang, Peter Watzinger, Peter Kötter, Karl-Dieter Entian |
None |
| Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth |
Clemens Heissenberger 1, Lisa Liendl 1, Fabian Nagelreiter 1, Yulia Gonskikh 2, Guohuan Yang 3, Elena M Stelzer 1, Teresa L Krammer 1, Lucia Micutkova 4, Stefan Vogt 1, David P Kreil 1, Gerhard Sekot 1, Emilio Siena 1, Ina Poser 5, Eva Harreither 1, Angela Linder 1, Viktoria Ehret 6, Thomas H Helbich 6, Regina Grillari-Voglauer 1, Pidder Jansen-Dürr 4, Martin Koš 3, Norbert Polacek 2, Johannes Grillari 1 7 8, Markus Schosserer |
None |
| Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program |
Maxime Janin 1, Vanessa Ortiz-Barahona 1, Manuel Castro de Moura 1, Anna Martínez-Cardús 1, Pere Llinàs-Arias 1, Marta Soler 1, Daphna Nachmani 2, Joffrey Pelletier 3, Ulrike Schumann 4, Maria E Calleja-Cervantes 1, Sebastian Moran 1, Sonia Guil 1, Alberto Bueno-Costa 1, David Piñeyro 1, Montserrat Perez-Salvia 1, Margalida Rosselló-Tortella 1, Laia Piqué 1, Joan J Bech-Serra 5, Carolina De La Torre 5, August Vidal 6 7, María Martínez-Iniesta 8, Juan F Martín-Tejera 8, Alberto Villanueva 8, Alexandra Arias 9, Isabel Cuartas 9, Ana M Aransay 10, Andres Morales La Madrid 11 12, Angel M Carcaboso 13, Vicente Santa-Maria 11 12, Jaume Mora 11, Agustin F Fernandez 14, Mario F Fraga 15, Iban Aldecoa 16, Leire Pedrosa 17, Francesc Graus 18, Noemi Vidal 6, Fina Martínez-Soler 19, Avelina Tortosa 19, Cristina Carrato 20, Carme Balañá 21, Matthew W Boudreau 22, Paul J Hergenrother 22, Peter Kötter 23, Karl-Dieter Entian 23, Jürgen Hench 24, Stephan Frank 24, Sheila Mansouri 25, Gelareh Zadeh 25, Pablo D Dans 26, Modesto Orozco 26 27, George Thomas 3 28 29, Sandra Blanco 30 31, Joan Seoane 7 9 32, Thomas Preiss 4 33, Pier Paolo Pandolfi 2, Manel Esteller |
None |
| The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans |
33289480 |
None |
| Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans |
|
None |
| An RNA modification enzyme directly senses reactive oxygen species for translational regulation in Enterococcus faecalis |
Wei Lin Lee 1, Ameya Sinha 1 2 3, Ling Ning Lam 2 4 5, Hooi Linn Loo 1, Jiaqi Liang 1 6, Peiying Ho 1, Liang Cui 1, Cheryl Siew Choo Chan 1 7, Thomas Begley 8, Kimberly Ann Kline 1 2 4 9, Peter Dedon |
None |
| Expanded tRNA methyltransferase family member TRMT9B regulates synaptic growth and function |
Caley A Hogan # 1, Scott J Gratz # 2, Jennifer L Dumouchel # 3, Rajan S Thakur 2, Ambar Delgado 2, Jenna M Lentini 4, Kimberly R Madhwani 5, Dragony Fu 4, Kate M O'Connor-Giles |
None |
| Biochemical characterization of mRNA capping enzyme from Faustovirus |
S Hong Chan 1, Christa N Molé 2, Dillon Nye 2, Lili Mitchell 2, Nan Dai 2, Jackson Buss 2, Daniel W Kneller 2, Joseph M Whipple 2, G Brett Robb |
None |
| Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease |
Da Oliviera, A., Dai, X., Mottaghinia, S., Geissler, E.P., Etienne, L., Zhang, Y., Mugridge, J.S. |
None |
| TRMT1-Catalyzed tRNA Modifications Are Required for Redox Homeostasis To Ensure Proper Cellular Proliferation and Oxidative Stress Survival |
Joshua M Dewe 1, Benjamin L Fuller 1, Jenna M Lentini 1, Stefanie M Kellner 2, Dragony Fu |
None |
| Human TRMT1 catalyzes m2G or m22G formation on tRNAs in a substrate-dependent manner |
Qing-Ping Xiong 1, Jing Li 2, Hao Li 2, Zhi-Xuan Huang 1 2, Han Dong 1, En-Duo Wang 3 4, Ru-Juan Liu |
None |
| Complete chemical structures of human mitochondrial tRNAs |
Takeo Suzuki 1 , Yuka Yashiro 1 , Ittoku Kikuchi 1 , Yuma Ishigami 1 , Hironori Saito 2 3 , Ikuya Matsuzawa 1 , Shunpei Okada 1 4 , Mari Mito 2 , Shintaro Iwasaki 2 3 , Ding Ma 1 , Xuewei Zhao 1 , Kana Asano 1 , Huan Lin 1 5 , Yohei Kirino 6 , Yuriko Sakaguchi 1 , Tsutomu Suzuki |
None |
| NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice |
Yoshitaka Murakami 1 2, Fan-Yan Wei 3, Yoshimi Kawamura 4, Haruki Horiguchi 5, Tsuyoshi Kadomatsu 5, Keishi Miyata 5, Kyoko Miura 4 6, Yuichi Oike 5 6, Yukio Ando 7, Mitsuharu Ueda 2 6, Kazuhito Tomizawa 8 9, Takeshi Chujo |
None |
| Identification of a novel 5-aminomethyl-2-thiouridine methyltransferase in tRNA modification. |
Cho, G., Lee, J., Kim, J. |
None |
| Crystal structure and cap binding analysis of the methyltransferase of langat virus |
Ruixue Li 1, Ziping Niu 2, Yujie Liu 2, Xue Bai 2, Deping Wang 3, Chen Chen |
None |
| Structure and function of the NS5 methyltransferase domain from Usutu virus |
Diego S Ferrero 1, Laura Albentosa-González 2, Antonio Mas 3, Nuria Verdaguer |
None |
| A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome. |
Shannon, A., Sama, B., Gauffre, P., Guez, T., Debart, F., Vasseur, J.J., Decroly, E., Canard, B., Ferron, F. |
None |
| A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription |
Hao Li, 1 , 2 , † Han Dong, 2 , † Beisi Xu, 3 , † Qing‐Ping Xiong, 2 Cai‐Tao Li, 1 , 2 Wen‐Qing Yang, 1 Jing Li, 1 Zhi‐Xuan Huang, 1 , 2 Qi‐Yu Zeng, 2 En‐Duo Wang,corresponding author 1 , 2 and Ru‐Juan Liucorresponding author 1 |
None |
| FIONA1 is an RNA N6-methyladenosine methyltransferase affecting Arabidopsis photomorphogenesis and flowering |
Chunling Wang # 1, Junbo Yang # 1, Peizhe Song 1, Wei Zhang 1, Qiang Lu 1, Qiong Yu 1, Guifang Jia |
None |
| Arabidopsis N6-methyladenosine methyltransferase FIONA1 regulates floral transition by affecting the splicing of FLC and the stability of floral activators SPL3 and SEP3 |
Jing Cai 1, Jianzhong Hu 1, Umme Amara 1, Su Jung Park 1, Yuxia Li 2, Daesong Jeong 3, Ilha Lee 3, Tao Xu 2, Hunseung Kang |
None |
| FIONA1-Mediated m6 A Modification Regulates the Floral Transition in Arabidopsis |
Tao Xu 1 2, Xiaowei Wu 1 2, Chui Eng Wong 1 2, Sheng Fan 2, Yu Zhang 1 2, Songyao Zhang 1, Zhe Liang 1 3, Hao Yu 1 2, Lisha Shen 2 |
None |
| m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5' splice site |
Matthew T Parker 1, Beth K Soanes 2, Jelena Kusakina 2, Antoine Larrieu 2, Katarzyna Knop 1, Nisha Joy 1, Friedrich Breidenbach 1 3, Anna V Sherwood 1, Geoffrey J Barton 1, Sebastian M Fica 4, Brendan H Davies 2, Gordon G Simpson 1 5 |
None |
| The immunophilin-interacting protein AtFIP37 from Arabidopsis is essential for plant development and is involved in trichome endoreduplication |
Laurent Vespa 1, Gilles Vachon, Frédéric Berger, Daniel Perazza, Jean-Denis Faure, Michel He |
None |
| Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI |
|
None |
| RNA methyltransferases in plants: Breakthroughs in function and evolution |
Ricardo Ferraz 1, Sílvia Coimbra 2, Sandra Correia 3, Jorge Canhoto 4 |
None |
| Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI |
Kamil Růžička 1 2, Mi Zhang 3, Ana Campilho 2 4, Zsuzsanna Bodi 3, Muhammad Kashif 2, Mária Saleh 1, Dominique Eeckhout 5 6, Sedeer El-Showk 2, Hongying Li 3 7, Silin Zhong 3 8, Geert De Jaeger 5 6, Nigel P Mongan 9, Jan Hejátko 1, Ykä Helariutta 2 10, Rupert G Fray |
None |